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- W4220851251 abstract "miR-1297 derived from BMSC-originated exosomes participates in modulating multiple malignancies. Our study aims to clarify the effect of miR-1297 derived from BMSC-originated exosomes on the oxidative stress and inflammatory damage of lung cancer cells. miR-1297 and NLRP3 level was measured in lung cancer tissues and para-cancerous tissues, as well as in lung cancer cell lines and pulmonary epithelial cells. After miR-1297-mimics transfection or BMSC co-cultivation, cell viability was assessed by MTT and cytokines were evaluated by ELISA along with analysis of SOD activity and cell apoptosis. miR-1297 and NLRP3 were significantly elevated in lung cancer tissues and cell lines. Overexpression of miR-1297 enhanced oxidative stress and inflammatory response, along with increased cell viability and decreased apoptosis. Additionally, co-culture with BMSC protect the viability of lung cancer cells by facilitating miR-1297/NLRP3. In conclusion, a significant elevation of miR-1297 is found in lung cancer tissues and cells. Its overexpression induced the release of inflammatory factors, thereby protecting the proliferating activity of lung cancer cells and restraining apoptosis, indicating that miR-1297 may serve a promising target for early diagnosis of lung cancers." @default.
- W4220851251 created "2022-04-03" @default.
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- W4220851251 date "2022-07-01" @default.
- W4220851251 modified "2023-09-23" @default.
- W4220851251 title "Bone Marrow Mesenchymal Stem Cells (BMSCs)-Triggered Up-Regulation of miR-1297/NLR Family Pyrin Domain Containing 3 (NLRP3) Facilitates the Aggressive Proliferation of Lung Cancer Cells via Inducing Inflammatory Factor Release" @default.
- W4220851251 doi "https://doi.org/10.1166/jbt.2022.3053" @default.
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