FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220851626> ?p ?o ?g. }

• W4220851626 endingPage "1591" @default.
• W4220851626 startingPage "1581" @default.
• W4220851626 abstract "Posterior capsular opacification (PCO) is a primary complication after phacoemulsification combined with intraocular lens (IOL) implantation, which is attributed to adhesion, proliferation, and migration of residual lens epithelial cells on IOL. Although surface hydrophilic coating is considered to be a powerful way to inhibit PCO incidence after surgery, it requires complex post-production processes, thus limiting their applicability. In comparison, bulk modification is a stable, effective, and facile IOL synthesis method for PCO prevention. Herein, a new anti-adhesive IOL material was designed and successfully synthesized by radical copolymerization of ethylene glycol phenyl ether methacrylate (EGPEMA) and 2-(2-ethoxyethoxy) ethyl acrylate (EA). The physicochemical properties of P(EGPEMA-co-EA) copolymer materials, including chemical structure, mechanical, thermal, surface, and optical properties, were analyzed by using 1H NMR spectroscopy, FT-IR spectroscopy, tensile test, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), water contact angle measurement, and UV-vis spectroscopy. The elongation at break and the modulus of elasticity of the copolymer were tunable through the change of the composition of monomers. Compared to other components, the tensile results showed that P(EGPEMA-co-EA) materials (70% EGPEMA in mass ratio, F7) are suitable for the preparation of foldable intraocular lens with lower elastic modulus and higher elongation at break. TGA and DSC showed that the material has high thermal stability, and the glass transition temperature of F7 material is 16.1 °C. The water contact angle measurement results showed that the introduction of EA improved the hydrophilicity of the material. The percentage of transmittance of all copolymers at 400-800 nm is above 85%. Then, the biocompatibility of the materials was evaluated by in vitro assay and subcutaneous implantation. Both in vitro results and subcutaneous implantation experiments showed that the designed IOL materials exhibited a good anti-adhesion effect and no cytotoxicity. Finally, phacoemulsification and IOL intraocular implantation were performed, and the in vivo results confirmed the good PCO prevention ability as well as the biocompatibility of the new IOL materials." @default.
• W4220851626 created "2022-04-03" @default.
• W4220851626 creator A5021199552 @default.
• W4220851626 creator A5048964462 @default.
• W4220851626 creator A5055265608 @default.
• W4220851626 creator A5056036725 @default.
• W4220851626 creator A5057341683 @default.
• W4220851626 creator A5067612263 @default.
• W4220851626 creator A5068095967 @default.
• W4220851626 date "2022-03-10" @default.
• W4220851626 modified "2023-10-15" @default.
• W4220851626 title "Foldable Bulk Anti-adhesive Polyacrylic Intraocular Lens Material Design and Fabrication for Posterior Capsule Opacification Prevention" @default.
• W4220851626 cites W1970441453 @default.
• W4220851626 cites W1976753803 @default.
• W4220851626 cites W1977398330 @default.
• W4220851626 cites W1984058369 @default.
• W4220851626 cites W2013568229 @default.
• W4220851626 cites W2020168894 @default.
• W4220851626 cites W2029332643 @default.
• W4220851626 cites W2037091860 @default.
• W4220851626 cites W2039368918 @default.
• W4220851626 cites W2045586439 @default.
• W4220851626 cites W2052201412 @default.
• W4220851626 cites W2072901323 @default.
• W4220851626 cites W2098905842 @default.
• W4220851626 cites W2136995532 @default.
• W4220851626 cites W2150361016 @default.
• W4220851626 cites W2151620238 @default.
• W4220851626 cites W2152389141 @default.
• W4220851626 cites W2153907503 @default.
• W4220851626 cites W2156545377 @default.
• W4220851626 cites W2171948069 @default.
• W4220851626 cites W2332005535 @default.
• W4220851626 cites W2399786191 @default.
• W4220851626 cites W2519224949 @default.
• W4220851626 cites W2529753381 @default.
• W4220851626 cites W2567697060 @default.
• W4220851626 cites W2579138815 @default.
• W4220851626 cites W2591609227 @default.
• W4220851626 cites W2745376615 @default.
• W4220851626 cites W2776540438 @default.
• W4220851626 cites W2789807066 @default.
• W4220851626 cites W2793243054 @default.
• W4220851626 cites W2794492890 @default.
• W4220851626 cites W2809007235 @default.
• W4220851626 cites W2891527658 @default.
• W4220851626 cites W2899862600 @default.
• W4220851626 cites W2964825032 @default.
• W4220851626 cites W2988969828 @default.
• W4220851626 cites W3024752452 @default.
• W4220851626 cites W3029438419 @default.
• W4220851626 cites W3042797754 @default.
• W4220851626 cites W3112609446 @default.
• W4220851626 cites W3118311948 @default.
• W4220851626 cites W3124344880 @default.
• W4220851626 cites W3135504994 @default.
• W4220851626 cites W3187239946 @default.
• W4220851626 cites W3202923684 @default.
• W4220851626 cites W1985956312 @default.
• W4220851626 doi "https://doi.org/10.1021/acs.biomac.1c01388" @default.
• W4220851626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35271252" @default.
• W4220851626 hasPublicationYear "2022" @default.
• W4220851626 type Work @default.
• W4220851626 citedByCount "3" @default.
• W4220851626 countsByYear W42208516262022 @default.
• W4220851626 countsByYear W42208516262023 @default.
• W4220851626 crossrefType "journal-article" @default.
• W4220851626 hasAuthorship W4220851626A5021199552 @default.
• W4220851626 hasAuthorship W4220851626A5048964462 @default.
• W4220851626 hasAuthorship W4220851626A5055265608 @default.
• W4220851626 hasAuthorship W4220851626A5056036725 @default.
• W4220851626 hasAuthorship W4220851626A5057341683 @default.
• W4220851626 hasAuthorship W4220851626A5067612263 @default.
• W4220851626 hasAuthorship W4220851626A5068095967 @default.
• W4220851626 hasConcept C112950240 @default.
• W4220851626 hasConcept C120665830 @default.
• W4220851626 hasConcept C121332964 @default.
• W4220851626 hasConcept C122865956 @default.
• W4220851626 hasConcept C132050475 @default.
• W4220851626 hasConcept C15920480 @default.
• W4220851626 hasConcept C159985019 @default.
• W4220851626 hasConcept C178790620 @default.
• W4220851626 hasConcept C185592680 @default.
• W4220851626 hasConcept C188027245 @default.
• W4220851626 hasConcept C192562407 @default.
• W4220851626 hasConcept C2779567214 @default.
• W4220851626 hasConcept C2779989194 @default.
• W4220851626 hasConcept C39519442 @default.
• W4220851626 hasConcept C521977710 @default.
• W4220851626 hasConcept C59061564 @default.
• W4220851626 hasConcept C60100273 @default.
• W4220851626 hasConcept C6556556 @default.
• W4220851626 hasConcept C97355855 @default.
• W4220851626 hasConceptScore W4220851626C112950240 @default.
• W4220851626 hasConceptScore W4220851626C120665830 @default.
• W4220851626 hasConceptScore W4220851626C121332964 @default.
• W4220851626 hasConceptScore W4220851626C122865956 @default.
• W4220851626 hasConceptScore W4220851626C132050475 @default.

• next