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- W4220851646 abstract "Macrophages are essential in eliciting antibody-dependent cellular phagocytosis (ADCP) of cancer cells. However, a satisfactory anticancer efficacy of ADCP is contingent on early antibody administration, and resistance develops along with cancer progression. Here, we investigate the mechanisms underlying ADCP and demonstrate an effective combinatorial strategy to potentiate its efficacy. We identified paclitaxel as a universal adjuvant that efficiently potentiated ADCP by a variety of anticancer antibodies in multiple cancers. Rather than eliciting cytotoxicity on cancer cells, paclitaxel polarized macrophages toward a state with enhanced phagocytic ability. Paclitaxel-treated macrophages down-regulated cell surface CSF1R whose expression was negatively correlated with patient survival in multiple malignancies. The suppression of CSF1R in macrophages enhanced ADCP of cancer cells, suggesting a role of CSF1R in regulating macrophage phagocytic ability. Together, these findings define a potent strategy for using conventional anticancer drugs to stimulate macrophage phagocytosis and promote the therapeutic efficacy of clinical anticancer antibodies." @default.
- W4220851646 created "2022-04-03" @default.
- W4220851646 creator A5000500580 @default.
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- W4220851646 creator A5074160022 @default.
- W4220851646 creator A5078109266 @default.
- W4220851646 creator A5082080649 @default.
- W4220851646 date "2022-03-18" @default.
- W4220851646 modified "2023-10-02" @default.
- W4220851646 title "Promoting antibody-dependent cellular phagocytosis for effective macrophage-based cancer immunotherapy" @default.
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