FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220851910> ?p ?o ?g. }

• W4220851910 endingPage "692" @default.
• W4220851910 startingPage "692" @default.
• W4220851910 abstract "Nivolumab, formulated in the medicine Opdivo® (10 mg/mL), is a therapeutic monoclonal antibody (mAb) used in the treatment of different types of cancer. Currently, there is insufficient knowledge about the behaviour of this protein with regards to the risk associated with its routine handling or unintentional mishandling, or when subjected to stress conditions in hospitals. These conditions can be simulated in forced degradation studies, which provide an in-depth understanding of the biophysical and biochemical properties of mAbs. In this study, we carried out a physicochemical and functional characterisation of nivolumab, which was subjected to various stress conditions: heat, freeze/thaw cycles, agitation, light exposure and high hypertonic solution. We used a wide range of analytical techniques: Far-UV CD, IT-FS, DLS, SE/UHPLC(UV)-[Native]MS, and ELISA. The results show that exposure to light was the stress test with the greatest impact on the samples, revelling the formation of non-natural dimers and a different isoform profile. In addition, nivolumab (Opdivo®) demonstrated stability up to 60 °C (1 h). As regards functionality all the nivolumab (Opdivo®) stressed samples were found to be stable except for those subjected to light and agitation, and to a lesser extent, those subjected to FTC 5 and NaCl stresses." @default.
• W4220851910 created "2022-04-03" @default.
• W4220851910 creator A5013401284 @default.
• W4220851910 creator A5042129483 @default.
• W4220851910 creator A5050179371 @default.
• W4220851910 creator A5062503108 @default.
• W4220851910 creator A5062787775 @default.
• W4220851910 date "2022-03-23" @default.
• W4220851910 modified "2023-10-10" @default.
• W4220851910 title "Comprehensive Analysis of Nivolumab, A Therapeutic Anti-Pd-1 Monoclonal Antibody: Impact of Handling and Stress" @default.
• W4220851910 cites W1900493176 @default.
• W4220851910 cites W1968287902 @default.
• W4220851910 cites W1984701286 @default.
• W4220851910 cites W2002121950 @default.
• W4220851910 cites W2007100595 @default.
• W4220851910 cites W2011684044 @default.
• W4220851910 cites W2026727321 @default.
• W4220851910 cites W2034274579 @default.
• W4220851910 cites W2037117759 @default.
• W4220851910 cites W2045936583 @default.
• W4220851910 cites W2069260705 @default.
• W4220851910 cites W2081640562 @default.
• W4220851910 cites W2094077114 @default.
• W4220851910 cites W2104571730 @default.
• W4220851910 cites W2118830268 @default.
• W4220851910 cites W2130756383 @default.
• W4220851910 cites W2132071446 @default.
• W4220851910 cites W2294206156 @default.
• W4220851910 cites W2399583684 @default.
• W4220851910 cites W2590586204 @default.
• W4220851910 cites W2751949649 @default.
• W4220851910 cites W2798152178 @default.
• W4220851910 cites W2803698905 @default.
• W4220851910 cites W2810391702 @default.
• W4220851910 cites W2811019845 @default.
• W4220851910 cites W2895855973 @default.
• W4220851910 cites W2920475100 @default.
• W4220851910 cites W2921608880 @default.
• W4220851910 cites W2928516752 @default.
• W4220851910 cites W2951763859 @default.
• W4220851910 cites W2982079059 @default.
• W4220851910 cites W2989927655 @default.
• W4220851910 cites W2999958881 @default.
• W4220851910 cites W3006360875 @default.
• W4220851910 cites W3037273347 @default.
• W4220851910 cites W3088068933 @default.
• W4220851910 cites W3120658566 @default.
• W4220851910 doi "https://doi.org/10.3390/pharmaceutics14040692" @default.
• W4220851910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35456527" @default.
• W4220851910 hasPublicationYear "2022" @default.
• W4220851910 type Work @default.
• W4220851910 citedByCount "4" @default.
• W4220851910 countsByYear W42208519102023 @default.
• W4220851910 crossrefType "journal-article" @default.
• W4220851910 hasAuthorship W4220851910A5013401284 @default.
• W4220851910 hasAuthorship W4220851910A5042129483 @default.
• W4220851910 hasAuthorship W4220851910A5050179371 @default.
• W4220851910 hasAuthorship W4220851910A5062503108 @default.
• W4220851910 hasAuthorship W4220851910A5062787775 @default.
• W4220851910 hasBestOaLocation W42208519101 @default.
• W4220851910 hasConcept C121608353 @default.
• W4220851910 hasConcept C126322002 @default.
• W4220851910 hasConcept C159654299 @default.
• W4220851910 hasConcept C185592680 @default.
• W4220851910 hasConcept C203014093 @default.
• W4220851910 hasConcept C2777701055 @default.
• W4220851910 hasConcept C2780030458 @default.
• W4220851910 hasConcept C542903549 @default.
• W4220851910 hasConcept C71924100 @default.
• W4220851910 hasConcept C98274493 @default.
• W4220851910 hasConceptScore W4220851910C121608353 @default.
• W4220851910 hasConceptScore W4220851910C126322002 @default.
• W4220851910 hasConceptScore W4220851910C159654299 @default.
• W4220851910 hasConceptScore W4220851910C185592680 @default.
• W4220851910 hasConceptScore W4220851910C203014093 @default.
• W4220851910 hasConceptScore W4220851910C2777701055 @default.
• W4220851910 hasConceptScore W4220851910C2780030458 @default.
• W4220851910 hasConceptScore W4220851910C542903549 @default.
• W4220851910 hasConceptScore W4220851910C71924100 @default.
• W4220851910 hasConceptScore W4220851910C98274493 @default.
• W4220851910 hasIssue "4" @default.
• W4220851910 hasLocation W42208519101 @default.
• W4220851910 hasLocation W42208519102 @default.
• W4220851910 hasLocation W42208519103 @default.
• W4220851910 hasLocation W42208519104 @default.
• W4220851910 hasLocation W42208519105 @default.
• W4220851910 hasLocation W42208519106 @default.
• W4220851910 hasLocation W42208519107 @default.
• W4220851910 hasOpenAccess W4220851910 @default.
• W4220851910 hasPrimaryLocation W42208519101 @default.
• W4220851910 hasRelatedWork W1969822711 @default.
• W4220851910 hasRelatedWork W1999686187 @default.
• W4220851910 hasRelatedWork W2019666956 @default.
• W4220851910 hasRelatedWork W2049834980 @default.
• W4220851910 hasRelatedWork W2063428357 @default.
• W4220851910 hasRelatedWork W2073840950 @default.
• W4220851910 hasRelatedWork W2340284051 @default.
• W4220851910 hasRelatedWork W2748952813 @default.

• next