FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220852422> ?p ?o ?g. }

• W4220852422 abstract "The kallikrein-kinin system is assumed to have a multifunctional role in health and disease, but its in vivo role in humans currently remains unclear owing to the divergence of plasma kinin level data published ranging from the low picomolar to high nanomolar range, even in healthy volunteers. Moreover, existing data are often restricted on reporting levels of single kinins, thus neglecting the distinct effects of active kinins on bradykinin (BK) receptors considering diverse metabolic pathways. A well-characterized and comprehensively evaluated healthy cohort is imperative for a better understanding of the biological variability of kinin profiles to enable reliable differentiation concerning disease-specific kinin profiles.To study biological levels and variability of kinin profiles comprehensively, 28 healthy adult volunteers were enrolled. Nasal lavage fluid and plasma were sampled in customized protease inhibitor prespiked tubes using standardized protocols, proven to limit inter-day and interindividual variability significantly. Nine kinins were quantitatively assessed using validated LC-MS/MS platforms: kallidin (KD), Hyp4-KD, KD1-9, BK, Hyp3-BK, BK1-8, BK1-7, BK1-5, and BK2-9. Kinin concentrations in nasal epithelial lining fluid were estimated by correlation using urea.Circulating plasma kinin levels were confirmed in the very low picomolar range with levels below 4.2 pM for BK and even lower levels for the other kinins. Endogenous kinin levels in nasal epithelial lining fluids were substantially higher, including median levels of 80.0 pM for KD and 139.1 pM for BK. Hydroxylated BK levels were higher than mean BK concentrations (Hyp3-BK/BK = 1.6), but hydroxylated KD levels were substantially lower than KD (Hyp4-KD/KD = 0.37). No gender-specific differences on endogenous kinin levels were found.This well-characterized healthy cohort enables investigation of the potential of kinins as biomarkers and would provide a valid control group to study alterations of kinin profiles in diseases, such as angioedema, sepsis, stroke, Alzheimer's disease, and COVID-19." @default.
• W4220852422 created "2022-04-03" @default.
• W4220852422 creator A5004343189 @default.
• W4220852422 creator A5031044502 @default.
• W4220852422 creator A5056104569 @default.
• W4220852422 date "2022-03-29" @default.
• W4220852422 modified "2023-10-14" @default.
• W4220852422 title "Mass spectrometric study of variation in kinin peptide profiles in nasal fluids and plasma of adult healthy individuals" @default.
• W4220852422 cites W109784360 @default.
• W4220852422 cites W1777223861 @default.
• W4220852422 cites W1989232305 @default.
• W4220852422 cites W2005386437 @default.
• W4220852422 cites W2047550261 @default.
• W4220852422 cites W2050588566 @default.
• W4220852422 cites W2053292076 @default.
• W4220852422 cites W2059906040 @default.
• W4220852422 cites W2070695415 @default.
• W4220852422 cites W2074188037 @default.
• W4220852422 cites W2076508250 @default.
• W4220852422 cites W2090238133 @default.
• W4220852422 cites W2092041427 @default.
• W4220852422 cites W2102953371 @default.
• W4220852422 cites W2126569426 @default.
• W4220852422 cites W2139000046 @default.
• W4220852422 cites W2156574746 @default.
• W4220852422 cites W2167128829 @default.
• W4220852422 cites W2177124431 @default.
• W4220852422 cites W2182674165 @default.
• W4220852422 cites W2187991480 @default.
• W4220852422 cites W2616929361 @default.
• W4220852422 cites W2770440335 @default.
• W4220852422 cites W2788259524 @default.
• W4220852422 cites W2792158386 @default.
• W4220852422 cites W2917161993 @default.
• W4220852422 cites W2968716215 @default.
• W4220852422 cites W3010182921 @default.
• W4220852422 cites W3017296511 @default.
• W4220852422 cites W3020423761 @default.
• W4220852422 cites W3021739873 @default.
• W4220852422 cites W3024408344 @default.
• W4220852422 cites W3034377779 @default.
• W4220852422 cites W3095038710 @default.
• W4220852422 cites W3115426113 @default.
• W4220852422 cites W3126293020 @default.
• W4220852422 cites W3133668063 @default.
• W4220852422 cites W3185315738 @default.
• W4220852422 cites W4206072950 @default.
• W4220852422 cites W4211171286 @default.
• W4220852422 cites W4233850368 @default.
• W4220852422 doi "https://doi.org/10.1186/s12967-022-03332-8" @default.
• W4220852422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35351153" @default.
• W4220852422 hasPublicationYear "2022" @default.
• W4220852422 type Work @default.
• W4220852422 citedByCount "1" @default.
• W4220852422 countsByYear W42208524222022 @default.
• W4220852422 crossrefType "journal-article" @default.
• W4220852422 hasAuthorship W4220852422A5004343189 @default.
• W4220852422 hasAuthorship W4220852422A5031044502 @default.
• W4220852422 hasAuthorship W4220852422A5056104569 @default.
• W4220852422 hasBestOaLocation W42208524221 @default.
• W4220852422 hasConcept C126322002 @default.
• W4220852422 hasConcept C134018914 @default.
• W4220852422 hasConcept C150903083 @default.
• W4220852422 hasConcept C170493617 @default.
• W4220852422 hasConcept C181199279 @default.
• W4220852422 hasConcept C185592680 @default.
• W4220852422 hasConcept C203014093 @default.
• W4220852422 hasConcept C207001950 @default.
• W4220852422 hasConcept C2776246183 @default.
• W4220852422 hasConcept C2779591629 @default.
• W4220852422 hasConcept C2779730486 @default.
• W4220852422 hasConcept C52853521 @default.
• W4220852422 hasConcept C55493867 @default.
• W4220852422 hasConcept C71924100 @default.
• W4220852422 hasConcept C86803240 @default.
• W4220852422 hasConceptScore W4220852422C126322002 @default.
• W4220852422 hasConceptScore W4220852422C134018914 @default.
• W4220852422 hasConceptScore W4220852422C150903083 @default.
• W4220852422 hasConceptScore W4220852422C170493617 @default.
• W4220852422 hasConceptScore W4220852422C181199279 @default.
• W4220852422 hasConceptScore W4220852422C185592680 @default.
• W4220852422 hasConceptScore W4220852422C203014093 @default.
• W4220852422 hasConceptScore W4220852422C207001950 @default.
• W4220852422 hasConceptScore W4220852422C2776246183 @default.
• W4220852422 hasConceptScore W4220852422C2779591629 @default.
• W4220852422 hasConceptScore W4220852422C2779730486 @default.
• W4220852422 hasConceptScore W4220852422C52853521 @default.
• W4220852422 hasConceptScore W4220852422C55493867 @default.
• W4220852422 hasConceptScore W4220852422C71924100 @default.
• W4220852422 hasConceptScore W4220852422C86803240 @default.
• W4220852422 hasFunder F4320321951 @default.
• W4220852422 hasIssue "1" @default.
• W4220852422 hasLocation W42208524221 @default.
• W4220852422 hasLocation W42208524222 @default.
• W4220852422 hasLocation W42208524223 @default.
• W4220852422 hasOpenAccess W4220852422 @default.
• W4220852422 hasPrimaryLocation W42208524221 @default.
• W4220852422 hasRelatedWork W104100394 @default.
• W4220852422 hasRelatedWork W1521060200 @default.
• W4220852422 hasRelatedWork W2034304959 @default.

• next