FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220852854> ?p ?o ?g. }

• W4220852854 endingPage "105714" @default.
• W4220852854 startingPage "105714" @default.
• W4220852854 abstract "Hyperphosphorylation of tau leads to conformational changes that destabilize microtubules and hinder axonal transport in Alzheimer's disease (AD). However, it remains unknown whether white matter (WM) decline due to AD is associated with specific Tau phosphorylation site(s).In autosomal dominant AD (ADAD) mutation carriers (MC) and non-carriers (NC) we compared cerebrospinal fluid (CSF) phosphorylation at tau sites (pT217, pT181, pS202, and pT205) and total tau with WM measures, as derived from diffusion tensor imaging (DTI), and cognition. A WM composite metric, derived from a principal component analysis, was used to identify spatial decline seen in ADAD.The WM composite explained over 70% of the variance in MC. WM regions that strongly contributed to the spatial topography were located in callosal and cingulate regions. Loss of integrity within the WM composite was strongly associated with AD progression in MC as defined by the estimated years to onset (EYO) and cognitive decline. A linear regression demonstrated that amyloid, gray matter atrophy and phosphorylation at CSF tau site pT205 each uniquely explained a reduction in the WM composite within MC that was independent of vascular changes (white matter hyperintensities), and age. Hyperphosphorylation of CSF tau at other sites and total tau did not significantly predict WM composite loss.We identified a site-specific relationship between CSF phosphorylated tau and WM decline within MC. The presence of both amyloid deposition and Tau phosphorylation at pT205 were associated with WM composite loss. These findings highlight a primary AD-specific mechanism for WM dysfunction that is tightly coupled to symptom manifestation and cognitive decline." @default.
• W4220852854 created "2022-04-03" @default.
• W4220852854 creator A5000597778 @default.
• W4220852854 creator A5002700915 @default.
• W4220852854 creator A5008695173 @default.
• W4220852854 creator A5010166794 @default.
• W4220852854 creator A5010912426 @default.
• W4220852854 creator A5022462599 @default.
• W4220852854 creator A5023066705 @default.
• W4220852854 creator A5023687317 @default.
• W4220852854 creator A5023869829 @default.
• W4220852854 creator A5024435882 @default.
• W4220852854 creator A5025837253 @default.
• W4220852854 creator A5033224484 @default.
• W4220852854 creator A5040490170 @default.
• W4220852854 creator A5048987900 @default.
• W4220852854 creator A5049785357 @default.
• W4220852854 creator A5054917382 @default.
• W4220852854 creator A5062159344 @default.
• W4220852854 creator A5063630764 @default.
• W4220852854 creator A5066984112 @default.
• W4220852854 creator A5068373508 @default.
• W4220852854 creator A5068417558 @default.
• W4220852854 creator A5076073942 @default.
• W4220852854 creator A5084033552 @default.
• W4220852854 creator A5088109475 @default.
• W4220852854 creator A5088321414 @default.
• W4220852854 creator A5088915384 @default.
• W4220852854 creator A5088998527 @default.
• W4220852854 creator A5090741969 @default.
• W4220852854 creator A5091046259 @default.
• W4220852854 date "2022-06-01" @default.
• W4220852854 modified "2023-10-14" @default.
• W4220852854 title "CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease" @default.
• W4220852854 cites W1743841615 @default.
• W4220852854 cites W1847168837 @default.
• W4220852854 cites W1968276382 @default.
• W4220852854 cites W1968553823 @default.
• W4220852854 cites W1977541817 @default.
• W4220852854 cites W1991952617 @default.
• W4220852854 cites W2008854521 @default.
• W4220852854 cites W2011554023 @default.
• W4220852854 cites W2013833879 @default.
• W4220852854 cites W2051737015 @default.
• W4220852854 cites W2058161128 @default.
• W4220852854 cites W2075421841 @default.
• W4220852854 cites W2078524519 @default.
• W4220852854 cites W2082429191 @default.
• W4220852854 cites W2097398649 @default.
• W4220852854 cites W2110431535 @default.
• W4220852854 cites W2111200377 @default.
• W4220852854 cites W2123782121 @default.
• W4220852854 cites W2126693856 @default.
• W4220852854 cites W2148080316 @default.
• W4220852854 cites W2150667092 @default.
• W4220852854 cites W2151889964 @default.
• W4220852854 cites W2158314129 @default.
• W4220852854 cites W2159994020 @default.
• W4220852854 cites W2167311298 @default.
• W4220852854 cites W2171250577 @default.
• W4220852854 cites W2344386354 @default.
• W4220852854 cites W2468090474 @default.
• W4220852854 cites W2518195265 @default.
• W4220852854 cites W2527711139 @default.
• W4220852854 cites W2563010764 @default.
• W4220852854 cites W2615506190 @default.
• W4220852854 cites W2782163737 @default.
• W4220852854 cites W2792694489 @default.
• W4220852854 cites W2802764933 @default.
• W4220852854 cites W2810413485 @default.
• W4220852854 cites W2810595994 @default.
• W4220852854 cites W2888559669 @default.
• W4220852854 cites W2892024211 @default.
• W4220852854 cites W2903697160 @default.
• W4220852854 cites W2905327499 @default.
• W4220852854 cites W2913321668 @default.
• W4220852854 cites W2945823364 @default.
• W4220852854 cites W2999113798 @default.
• W4220852854 cites W3009441391 @default.
• W4220852854 cites W3011927235 @default.
• W4220852854 cites W3012272172 @default.
• W4220852854 cites W3082754683 @default.
• W4220852854 doi "https://doi.org/10.1016/j.nbd.2022.105714" @default.
• W4220852854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35358703" @default.
• W4220852854 hasPublicationYear "2022" @default.
• W4220852854 type Work @default.
• W4220852854 citedByCount "2" @default.
• W4220852854 countsByYear W42208528542023 @default.
• W4220852854 crossrefType "journal-article" @default.
• W4220852854 hasAuthorship W4220852854A5000597778 @default.
• W4220852854 hasAuthorship W4220852854A5002700915 @default.
• W4220852854 hasAuthorship W4220852854A5008695173 @default.
• W4220852854 hasAuthorship W4220852854A5010166794 @default.
• W4220852854 hasAuthorship W4220852854A5010912426 @default.
• W4220852854 hasAuthorship W4220852854A5022462599 @default.
• W4220852854 hasAuthorship W4220852854A5023066705 @default.
• W4220852854 hasAuthorship W4220852854A5023687317 @default.
• W4220852854 hasAuthorship W4220852854A5023869829 @default.

• next