Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220854893> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4220854893 abstract "Appropriate antibiotics prescribing is key to treatment and to preventing mortality in patients with sepsis. The aim of this study was to determine the effect of the appropriate timing, spectrum, and dose of antibiotics on 28-day mortality in patients with sepsis.We performed a retrospective cohort observational study. We enrolled patients with sepsis in the emergency department of a tertiary care hospital between 1 March and 31 July 2019. Patients were coded into an appropriate antibiotics group (time, spectrum, dose) and an inappropriate antibiotics group. We collected information of patient characteristics, comorbidities, vital signs, laboratory test results, and initial treatment. We followed patient outcomes, 28-day mortality, hospital deaths, 28-day ventilator-free days, and 28-day hospital-free days.A total of 593 patients were enrolled, with 323 (54.46%) in the appropriate antibiotics group. We used multivariate logistic analyses to assess factors for mortality. Primary outcomes of appropriate antibiotics (administration within 60 min of triage, appropriate spectrum and dose) did not affect 28-day mortality (adjusted odds ratio [OR], 0.57; 95% confidence interval [CI] 0.22-1.144; P=0.23). Subgroup analysis showed that appropriate spectrum alone influenced 28-day mortality (adjusted OR, 0.38; 95% CI, 0.15-0.99; P=0.047). Appropriate antibiotics was not associated with in-hospital mortality (adjusted OR, 0.62; 95% CI, 0.29-1.30; P=0.21).Appropriate antibiotics included timing less than 60 min, spectrum and the dose was not significantly affected in 28-day mortality in emergency sepsis patients.The trial was retrospectively registered in the Thai Clinical Trial Registry, identification number TCTR20211216003 ." @default.
- W4220854893 created "2022-04-03" @default.
- W4220854893 creator A5031467566 @default.
- W4220854893 creator A5038436181 @default.
- W4220854893 creator A5039013087 @default.
- W4220854893 creator A5069136455 @default.
- W4220854893 date "2022-03-24" @default.
- W4220854893 modified "2023-10-06" @default.
- W4220854893 title "Effect of appropriate dose, spectrum, and timing of antibiotics on 28-day mortality in patients with sepsis in the emergency department" @default.
- W4220854893 cites W1993397663 @default.
- W4220854893 cites W2026332974 @default.
- W4220854893 cites W2059273647 @default.
- W4220854893 cites W2073316020 @default.
- W4220854893 cites W2280404143 @default.
- W4220854893 cites W2588534998 @default.
- W4220854893 cites W2599245417 @default.
- W4220854893 cites W2614741637 @default.
- W4220854893 cites W2755519540 @default.
- W4220854893 cites W2790158735 @default.
- W4220854893 cites W2794804323 @default.
- W4220854893 cites W2912904466 @default.
- W4220854893 cites W2913544880 @default.
- W4220854893 cites W2976291254 @default.
- W4220854893 cites W2981796771 @default.
- W4220854893 cites W2986383810 @default.
- W4220854893 cites W3023620462 @default.
- W4220854893 cites W3045454797 @default.
- W4220854893 cites W3202964273 @default.
- W4220854893 cites W750688012 @default.
- W4220854893 doi "https://doi.org/10.1186/s12245-022-00416-6" @default.
- W4220854893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35331130" @default.
- W4220854893 hasPublicationYear "2022" @default.
- W4220854893 type Work @default.
- W4220854893 citedByCount "1" @default.
- W4220854893 countsByYear W42208548932023 @default.
- W4220854893 crossrefType "journal-article" @default.
- W4220854893 hasAuthorship W4220854893A5031467566 @default.
- W4220854893 hasAuthorship W4220854893A5038436181 @default.
- W4220854893 hasAuthorship W4220854893A5039013087 @default.
- W4220854893 hasAuthorship W4220854893A5069136455 @default.
- W4220854893 hasBestOaLocation W42208548931 @default.
- W4220854893 hasConcept C118552586 @default.
- W4220854893 hasConcept C126322002 @default.
- W4220854893 hasConcept C151956035 @default.
- W4220854893 hasConcept C156957248 @default.
- W4220854893 hasConcept C167135981 @default.
- W4220854893 hasConcept C194828623 @default.
- W4220854893 hasConcept C2777120189 @default.
- W4220854893 hasConcept C2778384902 @default.
- W4220854893 hasConcept C2780724011 @default.
- W4220854893 hasConcept C44249647 @default.
- W4220854893 hasConcept C501593827 @default.
- W4220854893 hasConcept C71924100 @default.
- W4220854893 hasConcept C86803240 @default.
- W4220854893 hasConcept C89423630 @default.
- W4220854893 hasConceptScore W4220854893C118552586 @default.
- W4220854893 hasConceptScore W4220854893C126322002 @default.
- W4220854893 hasConceptScore W4220854893C151956035 @default.
- W4220854893 hasConceptScore W4220854893C156957248 @default.
- W4220854893 hasConceptScore W4220854893C167135981 @default.
- W4220854893 hasConceptScore W4220854893C194828623 @default.
- W4220854893 hasConceptScore W4220854893C2777120189 @default.
- W4220854893 hasConceptScore W4220854893C2778384902 @default.
- W4220854893 hasConceptScore W4220854893C2780724011 @default.
- W4220854893 hasConceptScore W4220854893C44249647 @default.
- W4220854893 hasConceptScore W4220854893C501593827 @default.
- W4220854893 hasConceptScore W4220854893C71924100 @default.
- W4220854893 hasConceptScore W4220854893C86803240 @default.
- W4220854893 hasConceptScore W4220854893C89423630 @default.
- W4220854893 hasIssue "1" @default.
- W4220854893 hasLocation W42208548931 @default.
- W4220854893 hasLocation W42208548932 @default.
- W4220854893 hasLocation W42208548933 @default.
- W4220854893 hasOpenAccess W4220854893 @default.
- W4220854893 hasPrimaryLocation W42208548931 @default.
- W4220854893 hasRelatedWork W2019937644 @default.
- W4220854893 hasRelatedWork W2023895448 @default.
- W4220854893 hasRelatedWork W2095526866 @default.
- W4220854893 hasRelatedWork W2123128061 @default.
- W4220854893 hasRelatedWork W2322256289 @default.
- W4220854893 hasRelatedWork W2335988042 @default.
- W4220854893 hasRelatedWork W2798127924 @default.
- W4220854893 hasRelatedWork W2974208464 @default.
- W4220854893 hasRelatedWork W3108902968 @default.
- W4220854893 hasRelatedWork W2188124135 @default.
- W4220854893 hasVolume "15" @default.
- W4220854893 isParatext "false" @default.
- W4220854893 isRetracted "false" @default.
- W4220854893 workType "article" @default.