Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220857776> ?p ?o ?g. }
- W4220857776 endingPage "1336" @default.
- W4220857776 startingPage "1324" @default.
- W4220857776 abstract "Despite the favourable efficacy profile of secukinumab, clinicians encounter varying clinical responses among patients potentially associated with under- and overdosing. As biologics are expensive, their rational use is crucial and evident. Therapeutic drug monitoring could guide clinicians in making decisions about treatment modifications.In this multicentre, prospective study, we aimed to develop and validate a secukinumab immunoassay and searched for the therapeutic window in patients with psoriasis.We determined secukinumab concentrations at trough in sera from 78 patients with psoriasis at multiple timepoints (Weeks 12, 24, 36, 48 and 52; after Week 52, measurements could be taken at an additional three timepoints) during maintenance phase, using an in-house secukinumab immunoassay consisting of a combination of MA-SEC66A2 as capture antibody and MA-SEC67A9, conjugated to horseradish peroxidase, as detecting antibody. At each hospital visit, disease severity was assessed using the Psoriasis Area and Severity Index (PASI).After quantification, 121 serum samples were included for dose-response analysis. Based on a linear mixed-effects model, secukinumab trough concentrations were found to decrease with increasing body mass index (BMI). Based on receiver operating characteristic (ROC) analysis, we concluded that the minimal effective secukinumab threshold was 39.1 mg/L in steady state, and that this was associated with a 92.7% probability of having an optimal clinical response (PASI ≤ 2 or reduction in PASI of ≥ 90%).Monitoring and targeting a secukinumab trough concentration of 39.1 mg/L may be a viable treatment option in suboptimal responders. In patients with higher BMI, weight-based dosing may be needed in order to prevent underdosing." @default.
- W4220857776 created "2022-04-03" @default.
- W4220857776 creator A5004501567 @default.
- W4220857776 creator A5006826596 @default.
- W4220857776 creator A5011017049 @default.
- W4220857776 creator A5024846292 @default.
- W4220857776 creator A5026245811 @default.
- W4220857776 creator A5045658215 @default.
- W4220857776 creator A5049468480 @default.
- W4220857776 creator A5068230066 @default.
- W4220857776 creator A5074388972 @default.
- W4220857776 date "2022-04-25" @default.
- W4220857776 modified "2023-10-14" @default.
- W4220857776 title "Therapeutic drug monitoring in dermatology: the way towards dose optimization of secukinumab in chronic plaque psoriasis" @default.
- W4220857776 cites W1488789440 @default.
- W4220857776 cites W1525774039 @default.
- W4220857776 cites W1917666393 @default.
- W4220857776 cites W1975130343 @default.
- W4220857776 cites W1978593886 @default.
- W4220857776 cites W2006617902 @default.
- W4220857776 cites W2014151562 @default.
- W4220857776 cites W2045676810 @default.
- W4220857776 cites W2066002096 @default.
- W4220857776 cites W2093274439 @default.
- W4220857776 cites W2300110679 @default.
- W4220857776 cites W2322299062 @default.
- W4220857776 cites W2462509855 @default.
- W4220857776 cites W2520255448 @default.
- W4220857776 cites W2573502983 @default.
- W4220857776 cites W2576647440 @default.
- W4220857776 cites W2594240753 @default.
- W4220857776 cites W2600786757 @default.
- W4220857776 cites W2737838244 @default.
- W4220857776 cites W2761161155 @default.
- W4220857776 cites W2768517818 @default.
- W4220857776 cites W2769504915 @default.
- W4220857776 cites W2790613941 @default.
- W4220857776 cites W2791720823 @default.
- W4220857776 cites W2792921896 @default.
- W4220857776 cites W2795044792 @default.
- W4220857776 cites W2800999810 @default.
- W4220857776 cites W2811469998 @default.
- W4220857776 cites W2883925086 @default.
- W4220857776 cites W2885610455 @default.
- W4220857776 cites W2905947025 @default.
- W4220857776 cites W2923455736 @default.
- W4220857776 cites W2936798031 @default.
- W4220857776 cites W2937688014 @default.
- W4220857776 cites W2940671601 @default.
- W4220857776 cites W2942920784 @default.
- W4220857776 cites W2944434778 @default.
- W4220857776 cites W2945527657 @default.
- W4220857776 cites W2950272595 @default.
- W4220857776 cites W2975645775 @default.
- W4220857776 cites W3021307263 @default.
- W4220857776 cites W3024377949 @default.
- W4220857776 cites W3041193795 @default.
- W4220857776 cites W3045278545 @default.
- W4220857776 cites W3089927745 @default.
- W4220857776 cites W3103233798 @default.
- W4220857776 cites W3107406060 @default.
- W4220857776 cites W3165381022 @default.
- W4220857776 cites W3171206910 @default.
- W4220857776 cites W3176834192 @default.
- W4220857776 cites W4233998745 @default.
- W4220857776 cites W4376595309 @default.
- W4220857776 doi "https://doi.org/10.1111/ced.15157" @default.
- W4220857776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35245966" @default.
- W4220857776 hasPublicationYear "2022" @default.
- W4220857776 type Work @default.
- W4220857776 citedByCount "2" @default.
- W4220857776 countsByYear W42208577762022 @default.
- W4220857776 countsByYear W42208577762023 @default.
- W4220857776 crossrefType "journal-article" @default.
- W4220857776 hasAuthorship W4220857776A5004501567 @default.
- W4220857776 hasAuthorship W4220857776A5006826596 @default.
- W4220857776 hasAuthorship W4220857776A5011017049 @default.
- W4220857776 hasAuthorship W4220857776A5024846292 @default.
- W4220857776 hasAuthorship W4220857776A5026245811 @default.
- W4220857776 hasAuthorship W4220857776A5045658215 @default.
- W4220857776 hasAuthorship W4220857776A5049468480 @default.
- W4220857776 hasAuthorship W4220857776A5068230066 @default.
- W4220857776 hasAuthorship W4220857776A5074388972 @default.
- W4220857776 hasBestOaLocation W42208577762 @default.
- W4220857776 hasConcept C126322002 @default.
- W4220857776 hasConcept C16005928 @default.
- W4220857776 hasConcept C2776260265 @default.
- W4220857776 hasConcept C2777011040 @default.
- W4220857776 hasConcept C2777288759 @default.
- W4220857776 hasConcept C2779786854 @default.
- W4220857776 hasConcept C2780564577 @default.
- W4220857776 hasConcept C71924100 @default.
- W4220857776 hasConceptScore W4220857776C126322002 @default.
- W4220857776 hasConceptScore W4220857776C16005928 @default.
- W4220857776 hasConceptScore W4220857776C2776260265 @default.
- W4220857776 hasConceptScore W4220857776C2777011040 @default.
- W4220857776 hasConceptScore W4220857776C2777288759 @default.
- W4220857776 hasConceptScore W4220857776C2779786854 @default.