Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220858621> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4220858621 abstract "Abstract Background Interleukin-1 (IL-1) is still regarded as the main offender that promotes the pro-inflammatory cascade in muscle injuries, tendopathies and especially in osteoarthritis. Thus, if present in high enough concentrations, IL-1receptor antagonist (IL-1Ra) has the potential to inhibit Interleukin-1. In this regard, autologous conditioned serum with an IL-1Ra/IL-1 ratio of at least > 10 might fulfill optimal therapeutic effects. The aim of the study was to analyze whether a pretreatment of patients with the oxygen insuffliation according to Regelsberger (IOI) might lead to an increased ratio of IL-RA to IL-1ß in autologous serum prepared after the respective therapy. Methods Venous blood from 15 patients which underwent intravenous oxygen insufflation (IOI) for routinely preventive purposes was taken before the first, the 6th, and the 9th session of intravenous oxygen insufflation. IL-1β and IL-1-RA levels were quantified from serum and from autologous conditioned serum (ACS) prepared from the drawn venous blood. Results Previous intravenous oxygen insufflation treatments significantly reduced IL-1β levels in autologous conditioned serum from mean 67.85 pg/ml (before the first treatment) down to mean 4.08 pg/ml (before the 9th treatment). Post conditioning levels of IL-1Ra were not changed to any significant degree (before 1st/before6th/ before 9 th treatment: 1038.37 ± 140.51 / 900.30 ± 79.24 / 902.84 ± 95.68). Thus, the IL-1Ra:IL-1β ratio was altered on a molecule to molecule basis from a mean of 37.03:1 up to a mean 223.54:1 through the pretreatment with oxygen insuffliation according to Regelsberger. Conclusion Pretreatment of patients with IOI alters the IL-1Ra:IL-1ß ratio of autologous conditioned serum to a more favorable ratio which might mitigate the inflammatory cascade more efficaciously. Therefore, we suggest to perform intravenous oxygen insufflation on patients before they give blood for preparing ACS." @default.
- W4220858621 created "2022-04-03" @default.
- W4220858621 creator A5014536293 @default.
- W4220858621 creator A5017010264 @default.
- W4220858621 date "2022-03-30" @default.
- W4220858621 modified "2023-09-26" @default.
- W4220858621 title "Intravenous oxygen insufflation (IOI) changes the IL-1-Ra:IL-1β ratio in autologous conditioned serum" @default.
- W4220858621 cites W1978511310 @default.
- W4220858621 cites W2081689224 @default.
- W4220858621 cites W2091822116 @default.
- W4220858621 cites W2103646425 @default.
- W4220858621 cites W2138492237 @default.
- W4220858621 cites W2147594818 @default.
- W4220858621 cites W2298897662 @default.
- W4220858621 cites W2300123487 @default.
- W4220858621 cites W2320387640 @default.
- W4220858621 cites W2535103699 @default.
- W4220858621 cites W2543834622 @default.
- W4220858621 cites W2709106418 @default.
- W4220858621 cites W2770296173 @default.
- W4220858621 cites W2883911404 @default.
- W4220858621 cites W2912486045 @default.
- W4220858621 cites W2990592352 @default.
- W4220858621 doi "https://doi.org/10.1186/s41231-021-00107-z" @default.
- W4220858621 hasPublicationYear "2022" @default.
- W4220858621 type Work @default.
- W4220858621 citedByCount "0" @default.
- W4220858621 crossrefType "journal-article" @default.
- W4220858621 hasAuthorship W4220858621A5014536293 @default.
- W4220858621 hasAuthorship W4220858621A5017010264 @default.
- W4220858621 hasBestOaLocation W42208586211 @default.
- W4220858621 hasConcept C126322002 @default.
- W4220858621 hasConcept C141071460 @default.
- W4220858621 hasConcept C2776892627 @default.
- W4220858621 hasConcept C2778690821 @default.
- W4220858621 hasConcept C3019433047 @default.
- W4220858621 hasConcept C42219234 @default.
- W4220858621 hasConcept C43044207 @default.
- W4220858621 hasConcept C71924100 @default.
- W4220858621 hasConcept C74172505 @default.
- W4220858621 hasConcept C90924648 @default.
- W4220858621 hasConceptScore W4220858621C126322002 @default.
- W4220858621 hasConceptScore W4220858621C141071460 @default.
- W4220858621 hasConceptScore W4220858621C2776892627 @default.
- W4220858621 hasConceptScore W4220858621C2778690821 @default.
- W4220858621 hasConceptScore W4220858621C3019433047 @default.
- W4220858621 hasConceptScore W4220858621C42219234 @default.
- W4220858621 hasConceptScore W4220858621C43044207 @default.
- W4220858621 hasConceptScore W4220858621C71924100 @default.
- W4220858621 hasConceptScore W4220858621C74172505 @default.
- W4220858621 hasConceptScore W4220858621C90924648 @default.
- W4220858621 hasIssue "1" @default.
- W4220858621 hasLocation W42208586211 @default.
- W4220858621 hasLocation W42208586212 @default.
- W4220858621 hasOpenAccess W4220858621 @default.
- W4220858621 hasPrimaryLocation W42208586211 @default.
- W4220858621 hasRelatedWork W2003938723 @default.
- W4220858621 hasRelatedWork W2047967234 @default.
- W4220858621 hasRelatedWork W2118496982 @default.
- W4220858621 hasRelatedWork W2364998975 @default.
- W4220858621 hasRelatedWork W2439875401 @default.
- W4220858621 hasRelatedWork W2956631740 @default.
- W4220858621 hasRelatedWork W3159358638 @default.
- W4220858621 hasRelatedWork W4220858621 @default.
- W4220858621 hasRelatedWork W4238867864 @default.
- W4220858621 hasRelatedWork W2525756941 @default.
- W4220858621 hasVolume "7" @default.
- W4220858621 isParatext "false" @default.
- W4220858621 isRetracted "false" @default.
- W4220858621 workType "article" @default.