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- W4220860169 abstract "Abstract Dopaminergic neurons with distinct projection patterns and physiological properties compose memory subsystems in a brain. However, it is poorly understood whether or how they interact during complex learning. Here, we identify a feedforward circuit formed between dopamine subsystems and show that it is essential for second-order conditioning, an ethologically important form of higher-order associative learning. The Drosophila mushroom body comprises a series of dopaminergic compartments, each of which exhibits distinct memory dynamics. We find that a slow and stable memory compartment can serve as an effective “teacher” by instructing other faster and transient memory compartments via a single key interneuron, which we identify by connectome analysis and neurotransmitter prediction. This excitatory interneuron acquires enhanced response to reward-predicting odor after first-order conditioning and, upon activation, evokes dopamine release in the “student” compartments. These hierarchical connections between dopamine subsystems explain distinct properties of first- and second-order memory long known by behavioral psychologists." @default.
- W4220860169 created "2022-04-03" @default.
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- W4220860169 date "2022-03-31" @default.
- W4220860169 modified "2023-10-02" @default.
- W4220860169 title "Hierarchical architecture of dopaminergic circuits enables second-order conditioning in <i>Drosophila</i>" @default.
- W4220860169 cites W1491075702 @default.
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- W4220860169 cites W1978530827 @default.
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- W4220860169 cites W2002379808 @default.
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- W4220860169 cites W2010724751 @default.
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- W4220860169 cites W2025296103 @default.
- W4220860169 cites W2026297218 @default.
- W4220860169 cites W2026992346 @default.
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- W4220860169 cites W2034278075 @default.
- W4220860169 cites W2034840220 @default.
- W4220860169 cites W2037824587 @default.
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- W4220860169 cites W2168552260 @default.
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- W4220860169 cites W2954712352 @default.
- W4220860169 cites W2999778183 @default.
- W4220860169 cites W3000091990 @default.
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- W4220860169 cites W3015422409 @default.
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- W4220860169 doi "https://doi.org/10.1101/2022.03.30.486484" @default.
- W4220860169 hasPublicationYear "2022" @default.
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