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- W4220862893 endingPage "100109" @default.
- W4220862893 startingPage "100109" @default.
- W4220862893 abstract "Despite improvements in the understanding of disease biology, pancreatic ductal adenocarcinoma (PDAC) remains the most malignant cancer of the pancreas. PDAC constitutes ∼95% of all pancreatic cancers, and it is highly resistant to therapeutics. The increased tissue rigidity, which stems from the rich fibrotic stroma in the tumor microenvironment, is central to disease development, physiology, and resistance to drug perfusion. Pancreatic stellate cells (PSCs) are responsible for overproduction of extracellular matrix in the fibrotic stroma, and this is exacerbated by the overexpression of transforming growth factor-β (TGF-β). However, there are few in vitro PDAC models, which include both PSCs and TGF-β or mimic in vivo-like tumor stiffness. In this study, we present a three-dimensional in vitro PDAC model, which includes PSCs and TGF-β, and recapitulates PDAC tissue mechanical stiffness. Using oscillatory shear rheology, we show the mechanical stiffness of the model is within range of the PDAC tissue stiffness by day 21 of culture and highlight that the matrix environment is essential to adequately capture PDAC disease. PDAC is a complex, aggressive disease with poor prognosis, and biophysically relevant in vitro PDAC models, which take into account tissue mechanics, will provide improved tumor models for effective therapeutic assessment." @default.
- W4220862893 created "2022-04-03" @default.
- W4220862893 creator A5019471426 @default.
- W4220862893 creator A5041373558 @default.
- W4220862893 creator A5048120892 @default.
- W4220862893 creator A5064065033 @default.
- W4220862893 creator A5064528233 @default.
- W4220862893 creator A5077740483 @default.
- W4220862893 creator A5086174439 @default.
- W4220862893 date "2022-06-01" @default.
- W4220862893 modified "2023-10-14" @default.
- W4220862893 title "Modeling the mechanical stiffness of pancreatic ductal adenocarcinoma" @default.
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