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• W4220866473 abstract "Estrogen receptor α (ERα) is a target for the treatment of ER-positive breast cancer patients. Paradoxically, it is also the initial site for estrogen (E2) to induce apoptosis in endocrine-resistant breast cancer. How ERα exhibits distinct functions, in different contexts, is the focus of numerous investigations. Compelling evidence demonstrated that unfolded protein response (UPR) is closely correlated with ER-positive breast cancer. Treatment with antiestrogens initially induces mild UPR through ERα with activation of three sensors of UPR-PRK-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1α (IRE1α), and activating transcription factor 6 (ATF6)-in the endoplasmic reticulum. Subsequently, these sensors interact with stress-associated transcription factors such as c-MYC, nuclear factor-κB (NF-κB), and hypoxia-inducible factor 1α (HIF1α), leading to acquired endocrine resistance. Paradoxically, E2 further activates sustained secondary UPR via ERα to induce apoptosis in endocrine-resistant breast cancer. Specifically, PERK plays a key role in inducing apoptosis, whereas IRE1α and ATF6 are involved in endoplasmic reticulum stress-associated degradation after E2 treatment. Furthermore, persistent activation of PERK deteriorates stress responses in mitochondria and triggers of NF-κB/tumor necrosis factor α (TNFα) axis, ultimately determining cell fate to apoptosis. The discovery of E2-induced apoptosis has clinical relevance for treatment of endocrine-resistant breast cancer. All of these findings demonstrate that ERα and associated UPR are double-edged swords in therapy for ER-positive breast cancer, depending on the duration and intensity of UPR stress. Herein, we address the mechanistic progress on how UPR leads to endocrine resistance and commits E2 to inducing apoptosis in endocrine-resistant breast cancer." @default.
• W4220866473 created "2022-04-03" @default.
• W4220866473 creator A5049919852 @default.
• W4220866473 creator A5084033038 @default.
• W4220866473 date "2022-03-01" @default.
• W4220866473 modified "2023-10-17" @default.
• W4220866473 title "Estrogen Receptor and the Unfolded Protein Response: Double-Edged Swords in Therapy for Estrogen Receptor-Positive Breast Cancer" @default.
• W4220866473 cites W1741173293 @default.
• W4220866473 cites W1836280751 @default.
• W4220866473 cites W1966157599 @default.
• W4220866473 cites W1968518726 @default.
• W4220866473 cites W1973822583 @default.
• W4220866473 cites W1978732061 @default.
• W4220866473 cites W1979592430 @default.
• W4220866473 cites W1981876883 @default.
• W4220866473 cites W1987868659 @default.
• W4220866473 cites W1988548899 @default.
• W4220866473 cites W1991250346 @default.
• W4220866473 cites W1992533338 @default.
• W4220866473 cites W1998466702 @default.
• W4220866473 cites W2004102172 @default.
• W4220866473 cites W2007598683 @default.
• W4220866473 cites W2013996883 @default.
• W4220866473 cites W2019192392 @default.
• W4220866473 cites W2021536610 @default.
• W4220866473 cites W2024606555 @default.
• W4220866473 cites W2027217739 @default.
• W4220866473 cites W2028450114 @default.
• W4220866473 cites W2031735388 @default.
• W4220866473 cites W2034693873 @default.
• W4220866473 cites W2038291983 @default.
• W4220866473 cites W2042803273 @default.
• W4220866473 cites W2043150684 @default.
• W4220866473 cites W2044055595 @default.
• W4220866473 cites W2044702943 @default.
• W4220866473 cites W2061674718 @default.
• W4220866473 cites W2065956782 @default.
• W4220866473 cites W2066538173 @default.
• W4220866473 cites W2070212927 @default.
• W4220866473 cites W2071535433 @default.
• W4220866473 cites W2079628366 @default.
• W4220866473 cites W2079643983 @default.
• W4220866473 cites W2080100430 @default.
• W4220866473 cites W2080901528 @default.
• W4220866473 cites W2081538666 @default.
• W4220866473 cites W2081998608 @default.
• W4220866473 cites W2085201901 @default.
• W4220866473 cites W2086407765 @default.
• W4220866473 cites W2088601708 @default.
• W4220866473 cites W2090556647 @default.
• W4220866473 cites W2094753012 @default.
• W4220866473 cites W2096283457 @default.
• W4220866473 cites W2097255042 @default.
• W4220866473 cites W2098407557 @default.
• W4220866473 cites W2098784161 @default.
• W4220866473 cites W2102025854 @default.
• W4220866473 cites W2105084636 @default.
• W4220866473 cites W2105374417 @default.
• W4220866473 cites W2106841768 @default.
• W4220866473 cites W2109957199 @default.
• W4220866473 cites W2110508238 @default.
• W4220866473 cites W2112605568 @default.
• W4220866473 cites W2113576333 @default.
• W4220866473 cites W2116119295 @default.
• W4220866473 cites W2120736516 @default.
• W4220866473 cites W2126327322 @default.
• W4220866473 cites W2127848114 @default.
• W4220866473 cites W2128741675 @default.
• W4220866473 cites W2130155828 @default.
• W4220866473 cites W2140276460 @default.
• W4220866473 cites W2141232624 @default.
• W4220866473 cites W2141358477 @default.
• W4220866473 cites W2155826575 @default.
• W4220866473 cites W2156933633 @default.
• W4220866473 cites W2158038535 @default.
• W4220866473 cites W2158333265 @default.
• W4220866473 cites W2159466552 @default.
• W4220866473 cites W2159588323 @default.
• W4220866473 cites W2161696602 @default.
• W4220866473 cites W2163327547 @default.
• W4220866473 cites W2163979252 @default.
• W4220866473 cites W2167188058 @default.
• W4220866473 cites W2167399292 @default.
• W4220866473 cites W2168215039 @default.
• W4220866473 cites W2169879031 @default.
• W4220866473 cites W2172697812 @default.
• W4220866473 cites W2176496044 @default.
• W4220866473 cites W2259802687 @default.
• W4220866473 cites W2314176140 @default.
• W4220866473 cites W2464719024 @default.
• W4220866473 cites W2527938089 @default.
• W4220866473 cites W2560011028 @default.
• W4220866473 cites W2614254014 @default.
• W4220866473 cites W2765240634 @default.
• W4220866473 cites W2766900039 @default.
• W4220866473 cites W2767348608 @default.
• W4220866473 cites W2768364368 @default.
• W4220866473 cites W2777085303 @default.

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