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- W4220868486 abstract "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused an ongoing global health crisis. Here, we present as a vaccine candidate synthetic SARS-CoV-2 spike (S) glycoprotein-coated lipid vesicles that resemble virus-like particles. Soluble S glycoprotein trimer stabilization by formaldehyde cross-linking introduces two major inter-protomer cross-links that keep all receptor-binding domains in the “down” conformation. Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses. Although anti-receptor-binding domain (RBD)-specific antibody responses are initially predominant, the third immunization boosts significant non-RBD antibody titers. Challenging vaccinated animals with SARS-CoV-2 shows a complete protection through sterilizing immunity, which correlates with the presence of nasopharyngeal anti-S immunoglobulin G (IgG) and IgA titers. Thus, the S-LV approach is an efficient and safe vaccine candidate based on a proven classical approach for further development and clinical testing." @default.
- W4220868486 created "2022-04-03" @default.
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- W4220868486 date "2022-02-01" @default.
- W4220868486 modified "2023-10-17" @default.
- W4220868486 title "Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects macaques from infection" @default.
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- W4220868486 cites W3038698073 @default.
- W4220868486 cites W3039066506 @default.
- W4220868486 cites W3039901154 @default.
- W4220868486 cites W3041564586 @default.
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