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- W4220870537 abstract "• New series of indole-chalcone linked 1,2,3-triazole hybrids was synthesized. • Indole-chalcone linked 1,2,3-triazole hybrids exhibited better antimicrobial activity compared to Indole aldehyde linked 1,2,3-triazoles. • 6a with MIC of 0.0063 µmol/mL was found to be most effective against R. oryzae. • Docking studies were performed with E. coli Gyr A and C. albicans 14- α- demethylase. The design and synthesis of a new series of indole-chalcone linked 1,2,3-triazole hybrids via Cu(Ι)-catalyzed azide-alkyne cycloaddition is reported. All the compounds ( 2, 4a–4e and 6a–6j ) were well characterized by different analytical and spectral methods and screened in vitro for antimicrobial evaluation against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Most of the synthesized hybrids showed significant potency with MIC values from 10.9 µM to 39.4 µM against bacterial strains. Antifungal data revealed that compound 6a with MIC of 6.3 µM was found to be most effective against R. oryzae. Docking simulations of the compounds 2, 4b and 6b were performed with of E. coli DNA gyrase, while molecule 6g along with 4b and 2 was docked into active sites of C. albicans alpha lanosterol demethylase." @default.
- W4220870537 created "2022-04-03" @default.
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- W4220870537 date "2022-08-01" @default.
- W4220870537 modified "2023-10-16" @default.
- W4220870537 title "Indole-chalcone linked 1,2,3-triazole hybrids: Facile synthesis, antimicrobial evaluation and docking studies as potential antimicrobial agents" @default.
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- W4220870537 doi "https://doi.org/10.1016/j.molstruc.2022.132867" @default.
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