Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220871184> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4220871184 endingPage "698" @default.
- W4220871184 startingPage "691" @default.
- W4220871184 abstract "Background aims The final harvest or wash of a cell therapy product is an important step in manufacturing, as viable cell recovery is critical to the overall success of a cell therapy. Most harvest/wash approaches in the clinical lab involve centrifugation, which can lead to loss of cells and decreased viability of the final product. Here the authors report on a multi-center assessment of the LOVO Cell Processing System (Fresenius Kabi, Bad Homburg, Germany), a cell processing device that uses a spinning filtration membrane instead of centrifugation. Methods Four National Institutes of Health Production Assistance for Cellular Therapies cell processing facilities (CPFs) assessed the LOVO Cell Processing System for final harvest and/or wash of the following three different cell products: activated T cells (ATCs), tumor-infiltrating lymphocytes (TILs) and bone marrow-derived mesenchymal stromal cells (MSCs). Each site compared their current in-house, routinely used method of final cell harvest and/or wash with that of the LOVO device. Results Final harvest and/or wash of ATCs, TILs and MSCs using the LOVO system resulted in satisfactory cell viability and recovery with some substantial improvement over the in-house methods of CPFs. Processing time was variable among cell types/facilities. Conclusions The LOVO Cell Processing System provides an alternative to centrifuge-based technologies. The system employs a spinning membrane filter, exposing cells to minimal g-forces compared with centrifugation, and is automated and closed. This small multi-center study demonstrated the ability of the LOVO device to yield satisfactory cell viability and recovery of T cells and MSCs." @default.
- W4220871184 created "2022-04-03" @default.
- W4220871184 creator A5001198212 @default.
- W4220871184 creator A5007520111 @default.
- W4220871184 creator A5009968414 @default.
- W4220871184 creator A5013401398 @default.
- W4220871184 creator A5017086357 @default.
- W4220871184 creator A5024963146 @default.
- W4220871184 creator A5037874094 @default.
- W4220871184 creator A5039198744 @default.
- W4220871184 creator A5050020111 @default.
- W4220871184 creator A5061426484 @default.
- W4220871184 creator A5062012695 @default.
- W4220871184 creator A5067694492 @default.
- W4220871184 creator A5076737035 @default.
- W4220871184 creator A5078636622 @default.
- W4220871184 creator A5085774808 @default.
- W4220871184 date "2022-07-01" @default.
- W4220871184 modified "2023-09-23" @default.
- W4220871184 title "Assessment of the LOVO device for final harvest of novel cell therapies: a Production Assistance for Cellular Therapies multi-center study" @default.
- W4220871184 cites W1936552712 @default.
- W4220871184 cites W2020241554 @default.
- W4220871184 cites W2089828715 @default.
- W4220871184 cites W2551558340 @default.
- W4220871184 cites W2599679234 @default.
- W4220871184 cites W2659073366 @default.
- W4220871184 cites W3165329193 @default.
- W4220871184 doi "https://doi.org/10.1016/j.jcyt.2022.01.010" @default.
- W4220871184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35279374" @default.
- W4220871184 hasPublicationYear "2022" @default.
- W4220871184 type Work @default.
- W4220871184 citedByCount "0" @default.
- W4220871184 crossrefType "journal-article" @default.
- W4220871184 hasAuthorship W4220871184A5001198212 @default.
- W4220871184 hasAuthorship W4220871184A5007520111 @default.
- W4220871184 hasAuthorship W4220871184A5009968414 @default.
- W4220871184 hasAuthorship W4220871184A5013401398 @default.
- W4220871184 hasAuthorship W4220871184A5017086357 @default.
- W4220871184 hasAuthorship W4220871184A5024963146 @default.
- W4220871184 hasAuthorship W4220871184A5037874094 @default.
- W4220871184 hasAuthorship W4220871184A5039198744 @default.
- W4220871184 hasAuthorship W4220871184A5050020111 @default.
- W4220871184 hasAuthorship W4220871184A5061426484 @default.
- W4220871184 hasAuthorship W4220871184A5062012695 @default.
- W4220871184 hasAuthorship W4220871184A5067694492 @default.
- W4220871184 hasAuthorship W4220871184A5076737035 @default.
- W4220871184 hasAuthorship W4220871184A5078636622 @default.
- W4220871184 hasAuthorship W4220871184A5085774808 @default.
- W4220871184 hasConcept C10882517 @default.
- W4220871184 hasConcept C136229726 @default.
- W4220871184 hasConcept C142724271 @default.
- W4220871184 hasConcept C1491633281 @default.
- W4220871184 hasConcept C16930146 @default.
- W4220871184 hasConcept C185592680 @default.
- W4220871184 hasConcept C198826908 @default.
- W4220871184 hasConcept C2994508507 @default.
- W4220871184 hasConcept C41625074 @default.
- W4220871184 hasConcept C43617362 @default.
- W4220871184 hasConcept C502942594 @default.
- W4220871184 hasConcept C53227056 @default.
- W4220871184 hasConcept C55493867 @default.
- W4220871184 hasConcept C71924100 @default.
- W4220871184 hasConcept C7623868 @default.
- W4220871184 hasConceptScore W4220871184C10882517 @default.
- W4220871184 hasConceptScore W4220871184C136229726 @default.
- W4220871184 hasConceptScore W4220871184C142724271 @default.
- W4220871184 hasConceptScore W4220871184C1491633281 @default.
- W4220871184 hasConceptScore W4220871184C16930146 @default.
- W4220871184 hasConceptScore W4220871184C185592680 @default.
- W4220871184 hasConceptScore W4220871184C198826908 @default.
- W4220871184 hasConceptScore W4220871184C2994508507 @default.
- W4220871184 hasConceptScore W4220871184C41625074 @default.
- W4220871184 hasConceptScore W4220871184C43617362 @default.
- W4220871184 hasConceptScore W4220871184C502942594 @default.
- W4220871184 hasConceptScore W4220871184C53227056 @default.
- W4220871184 hasConceptScore W4220871184C55493867 @default.
- W4220871184 hasConceptScore W4220871184C71924100 @default.
- W4220871184 hasConceptScore W4220871184C7623868 @default.
- W4220871184 hasIssue "7" @default.
- W4220871184 hasLocation W42208711841 @default.
- W4220871184 hasLocation W42208711842 @default.
- W4220871184 hasOpenAccess W4220871184 @default.
- W4220871184 hasPrimaryLocation W42208711841 @default.
- W4220871184 hasRelatedWork W2019441228 @default.
- W4220871184 hasRelatedWork W2273720212 @default.
- W4220871184 hasRelatedWork W2317205047 @default.
- W4220871184 hasRelatedWork W2793978630 @default.
- W4220871184 hasRelatedWork W3018000454 @default.
- W4220871184 hasRelatedWork W3027650627 @default.
- W4220871184 hasRelatedWork W3121730755 @default.
- W4220871184 hasRelatedWork W3126159904 @default.
- W4220871184 hasRelatedWork W4220871184 @default.
- W4220871184 hasRelatedWork W4248402699 @default.
- W4220871184 hasVolume "24" @default.
- W4220871184 isParatext "false" @default.
- W4220871184 isRetracted "false" @default.
- W4220871184 workType "article" @default.