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- W4220871749 endingPage "3753" @default.
- W4220871749 startingPage "3753" @default.
- W4220871749 abstract "Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease deriving from the hair follicles. The formation of inflammatory nodules, abscesses, fistulas, and sinus tracts is characterized by a large inflow of key pro-inflammatory mediators, such as IFN-γ, TNF-α, IL-1, IL-17, and IL-12/23. Adalimumab is currently the only Food and Drug Administration (FDA)- and European Medicines Agency (EMA)-approved biologic therapy for moderate to severe HS in adults and adolescents. However, the long-term effectiveness of this TNF-α inhibitor in HS patients has shown to be highly variable. This review aims to review the evidence for emerging therapies that target the main pro-inflammatory cytokines in HS pathogenesis. A review of the literature was conducted, using the PubMed and Google Scholar repositories, as well as Clinicaltrials.gov. Presently, the most promising biologics in phase III trials are anti-IL-17 antibodies, secukinumab, and bimekizumab. Furthermore, an anti-IL-1 biologic, bermekimab, is currently in phase II trials, and shows encouraging results. Overall, the clinical efficacies of all new targeted therapies published up to this point are limited. More studies need to be performed to clarify the precise molecular pathology, and assess the efficacy of biological therapies for HS." @default.
- W4220871749 created "2022-04-03" @default.
- W4220871749 creator A5050935648 @default.
- W4220871749 creator A5084517399 @default.
- W4220871749 creator A5088853535 @default.
- W4220871749 date "2022-03-29" @default.
- W4220871749 modified "2023-10-18" @default.
- W4220871749 title "New and Emerging Targeted Therapies for Hidradenitis Suppurativa" @default.
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