Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220872600> ?p ?o ?g. }
- W4220872600 endingPage "182" @default.
- W4220872600 startingPage "173" @default.
- W4220872600 abstract "Critical illness myopathy (CIM) is a common neuro-muscular complication of intensive care treatment associated with increased morbidity and mortality. The current guidelines for diagnosis include clinical and electrophysiological criteria as well as a muscle biopsy, and allow diagnosis only at an advanced stage of the disease. To date, there is no treatment for CIM available, apart from symptomatic and rehabilitative interventions. In this review, we discuss different diagnostic approaches and describe new treatment possibilities for CIM.Of the diagnostic approaches evaluated, a new electrophysiological technique for measuring muscle excitability has the greatest potential to allow earlier diagnosis of CIM than the current guidelines do and thereby may facilitate the conduction of future pathophysiological and therapeutic studies. Although clinical trials are still lacking, in animal models, BGP-15, vamorolone, and ruxolitinib have been shown to have anti-inflammatory effects, to reduce muscle wasting and to improve muscle function and survival.In recent years, promising methods for early and confirmatory diagnosis of CIM have been developed, but still need validation. Experimental studies on novel pharmacological interventions show promising results in terms of preventive CIM treatments, but future clinical studies will be needed to study the effectiveness and safety of these drugs." @default.
- W4220872600 created "2022-04-03" @default.
- W4220872600 creator A5006302212 @default.
- W4220872600 creator A5007528213 @default.
- W4220872600 creator A5063059811 @default.
- W4220872600 date "2022-03-28" @default.
- W4220872600 modified "2023-10-14" @default.
- W4220872600 title "Critical Illness Myopathy: Diagnostic Approach and Resulting Therapeutic Implications" @default.
- W4220872600 cites W1539497848 @default.
- W4220872600 cites W1549579876 @default.
- W4220872600 cites W1968129827 @default.
- W4220872600 cites W1978492957 @default.
- W4220872600 cites W1979435675 @default.
- W4220872600 cites W1980069082 @default.
- W4220872600 cites W1987306333 @default.
- W4220872600 cites W1993353641 @default.
- W4220872600 cites W1996735231 @default.
- W4220872600 cites W2003567405 @default.
- W4220872600 cites W2004441226 @default.
- W4220872600 cites W2005373784 @default.
- W4220872600 cites W2005971230 @default.
- W4220872600 cites W2013720506 @default.
- W4220872600 cites W2014232635 @default.
- W4220872600 cites W2017837793 @default.
- W4220872600 cites W2020230229 @default.
- W4220872600 cites W2023134354 @default.
- W4220872600 cites W2041424015 @default.
- W4220872600 cites W2041638411 @default.
- W4220872600 cites W2042705095 @default.
- W4220872600 cites W2043482955 @default.
- W4220872600 cites W2045023541 @default.
- W4220872600 cites W2048759663 @default.
- W4220872600 cites W2048977247 @default.
- W4220872600 cites W2053109028 @default.
- W4220872600 cites W2054069920 @default.
- W4220872600 cites W2058920799 @default.
- W4220872600 cites W2060176865 @default.
- W4220872600 cites W2074056314 @default.
- W4220872600 cites W2082678664 @default.
- W4220872600 cites W2083688004 @default.
- W4220872600 cites W2084081856 @default.
- W4220872600 cites W2084668960 @default.
- W4220872600 cites W2092396612 @default.
- W4220872600 cites W2111168097 @default.
- W4220872600 cites W2111861407 @default.
- W4220872600 cites W2113621578 @default.
- W4220872600 cites W2118240638 @default.
- W4220872600 cites W2127927152 @default.
- W4220872600 cites W2128824699 @default.
- W4220872600 cites W2129241371 @default.
- W4220872600 cites W2130577637 @default.
- W4220872600 cites W2145053281 @default.
- W4220872600 cites W2145796234 @default.
- W4220872600 cites W2145827333 @default.
- W4220872600 cites W2146346947 @default.
- W4220872600 cites W2146437871 @default.
- W4220872600 cites W2154038687 @default.
- W4220872600 cites W2163157068 @default.
- W4220872600 cites W2163415084 @default.
- W4220872600 cites W2167813481 @default.
- W4220872600 cites W2168622494 @default.
- W4220872600 cites W2170128875 @default.
- W4220872600 cites W2208931577 @default.
- W4220872600 cites W2300066317 @default.
- W4220872600 cites W2315812255 @default.
- W4220872600 cites W2326471898 @default.
- W4220872600 cites W2331048724 @default.
- W4220872600 cites W2571548403 @default.
- W4220872600 cites W2609483572 @default.
- W4220872600 cites W2785669916 @default.
- W4220872600 cites W2792574008 @default.
- W4220872600 cites W2886306865 @default.
- W4220872600 cites W2971772909 @default.
- W4220872600 cites W2992845302 @default.
- W4220872600 cites W3000788519 @default.
- W4220872600 cites W3008610242 @default.
- W4220872600 cites W3022236234 @default.
- W4220872600 cites W3084022240 @default.
- W4220872600 cites W3092805396 @default.
- W4220872600 cites W3102525601 @default.
- W4220872600 cites W3133406902 @default.
- W4220872600 cites W3137637703 @default.
- W4220872600 cites W3139372485 @default.
- W4220872600 cites W3144182075 @default.
- W4220872600 cites W3144999215 @default.
- W4220872600 cites W3148279024 @default.
- W4220872600 cites W4223889479 @default.
- W4220872600 cites W4230255979 @default.
- W4220872600 doi "https://doi.org/10.1007/s11940-022-00714-7" @default.
- W4220872600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35370393" @default.
- W4220872600 hasPublicationYear "2022" @default.
- W4220872600 type Work @default.
- W4220872600 citedByCount "2" @default.
- W4220872600 countsByYear W42208726002022 @default.
- W4220872600 crossrefType "journal-article" @default.
- W4220872600 hasAuthorship W4220872600A5006302212 @default.
- W4220872600 hasAuthorship W4220872600A5007528213 @default.
- W4220872600 hasAuthorship W4220872600A5063059811 @default.