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- W4220872802 abstract "Gestational low-protein (LP) diet leads to glucose intolerance and insulin resistance in adult offspring. We had earlier demonstrated that LP programming affects glucose disposal in females. Mitochondrial health is crucial for normal glucose metabolism in skeletal muscle. In this study, we sought to analyze mitochondrial structure, function, and associated genes in skeletal muscles to explore the molecular mechanism of insulin resistance LP-programmed female offspring. On day four of pregnancy, rats were assigned to a control diet containing 20% protein or an isocaloric 6% protein-containing diet. Standard laboratory diet was given to the dams after delivery until the end of weaning and to pups after weaning. Gestational LP diet led to changes in mitochondrial ultrastructure in the gastrocnemius muscles, including a nine-fold increase in the presence of giant mitochondria along with unevenly formed cristae. Further, functional analysis showed that LP programming caused impaired mitochondrial functions. Although the mitochondrial copy number did not show significant changes, key genes involved in mitochondrial structure and function such as Fis1, Opa1, Mfn2, Nrf1, Nrf2, Pgc1b, Cox4b, Esrra, and Vdac were dysregulated. Our study shows that prenatal LP programming induced disruption in mitochondrial ultrastructure and function in the skeletal muscle of female offspring." @default.
- W4220872802 created "2022-04-03" @default.
- W4220872802 creator A5006632101 @default.
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- W4220872802 creator A5080753511 @default.
- W4220872802 date "2022-03-09" @default.
- W4220872802 modified "2023-10-14" @default.
- W4220872802 title "Prenatal Low-Protein Diet Affects Mitochondrial Structure and Function in the Skeletal Muscle of Adult Female Offspring" @default.
- W4220872802 cites W116808744 @default.
- W4220872802 cites W1414125020 @default.
- W4220872802 cites W1580646470 @default.
- W4220872802 cites W1592830383 @default.
- W4220872802 cites W1964619095 @default.
- W4220872802 cites W1968826789 @default.
- W4220872802 cites W1974434128 @default.
- W4220872802 cites W1974939683 @default.
- W4220872802 cites W1976998737 @default.
- W4220872802 cites W1982359478 @default.
- W4220872802 cites W1985280131 @default.
- W4220872802 cites W1986248905 @default.
- W4220872802 cites W2001819241 @default.
- W4220872802 cites W2003188067 @default.
- W4220872802 cites W2004215000 @default.
- W4220872802 cites W2006754278 @default.
- W4220872802 cites W2009727112 @default.
- W4220872802 cites W2009841793 @default.
- W4220872802 cites W2017023704 @default.
- W4220872802 cites W2024887680 @default.
- W4220872802 cites W2033063191 @default.
- W4220872802 cites W2033665082 @default.
- W4220872802 cites W2035118995 @default.
- W4220872802 cites W2049481764 @default.
- W4220872802 cites W2049550249 @default.
- W4220872802 cites W2055909981 @default.
- W4220872802 cites W2058599282 @default.
- W4220872802 cites W2061113435 @default.
- W4220872802 cites W2061617584 @default.
- W4220872802 cites W2064283198 @default.
- W4220872802 cites W2067074932 @default.
- W4220872802 cites W2069960997 @default.
- W4220872802 cites W2090668525 @default.
- W4220872802 cites W2091673304 @default.
- W4220872802 cites W2093366966 @default.
- W4220872802 cites W2103963020 @default.
- W4220872802 cites W2105364942 @default.
- W4220872802 cites W2106672194 @default.
- W4220872802 cites W2108514816 @default.
- W4220872802 cites W2109349587 @default.
- W4220872802 cites W2110891510 @default.
- W4220872802 cites W2110952210 @default.
- W4220872802 cites W2112522013 @default.
- W4220872802 cites W2112906476 @default.
- W4220872802 cites W2116248509 @default.
- W4220872802 cites W2122442017 @default.
- W4220872802 cites W2123106337 @default.
- W4220872802 cites W2126317966 @default.
- W4220872802 cites W2127806759 @default.
- W4220872802 cites W2130758099 @default.
- W4220872802 cites W2132623660 @default.
- W4220872802 cites W2135070381 @default.
- W4220872802 cites W2135264898 @default.
- W4220872802 cites W2140093065 @default.
- W4220872802 cites W2140513290 @default.
- W4220872802 cites W2144866168 @default.
- W4220872802 cites W2146051127 @default.
- W4220872802 cites W2148713009 @default.
- W4220872802 cites W2149608505 @default.
- W4220872802 cites W2151974497 @default.
- W4220872802 cites W2154726349 @default.
- W4220872802 cites W2156579830 @default.
- W4220872802 cites W2158088166 @default.
- W4220872802 cites W2164276482 @default.
- W4220872802 cites W2220465878 @default.
- W4220872802 cites W2341191268 @default.
- W4220872802 cites W2341717561 @default.
- W4220872802 cites W2411524179 @default.
- W4220872802 cites W2507486477 @default.
- W4220872802 cites W2600672741 @default.
- W4220872802 cites W2769573273 @default.
- W4220872802 cites W2883221432 @default.
- W4220872802 cites W2887148828 @default.
- W4220872802 cites W2912632286 @default.
- W4220872802 cites W2921364326 @default.
- W4220872802 cites W296161204 @default.
- W4220872802 cites W2963017100 @default.
- W4220872802 cites W3007938047 @default.
- W4220872802 cites W3012554094 @default.
- W4220872802 cites W3048346056 @default.
- W4220872802 cites W3109447570 @default.
- W4220872802 cites W3112582248 @default.
- W4220872802 cites W4232897593 @default.
- W4220872802 cites W4324264902 @default.
- W4220872802 doi "https://doi.org/10.3390/nu14061158" @default.
- W4220872802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35334815" @default.
- W4220872802 hasPublicationYear "2022" @default.
- W4220872802 type Work @default.