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• W4220873629 startingPage "53" @default.
• W4220873629 abstract "There have been many advances in tissue engineering with respect to in vitro and in vivo models of oral mucosa equivalents (OMEs). To apply in vitro reconstructed oral mucosa models to regenerative medicine and adopt them as alternatives to animal testing, it is necessary to develop the technology of reconstructing different types of oral tissues, such as epithelial differentiation control and introduction of appendages. We previously reported that functional three-dimensional (3D) tissue models could be quickly constructed using a layer-by-layer (LbL) cell coating technique that assembles extracellular matrix (ECM) nanofilms on a cell surface. In this study, 3D human OMEs composed of lamina-propria, keratinized or non-keratinized epithelium and blood capillaries were constructed using the LbL cell coating technology. Human oral mucosal fibroblasts (HOMFs) were coated with ECM nanofilms and accumulated for the construction of oral mucosal lamina-propria. To construct OMEs with keratinized or nonkeratinized epithelium, human oral keratinocytes isolated from gingiva (human oral gingival keratinocytes: HOGKs) or human oral keratinocytes isolated from oral mucosa (human oral mucosal keratinocytes: HOMKs) were used in this study. We further studied the construction of epithelialized OMEs with density- and size-controlled blood capillary networks using human umbilical vein endothelial cells (HUVECs). It was revealed that these constructions had barrier functions in accordance with their histological characterization. The OMEs with keratinization (K-OMEs) showed higher transepithelial electrical resistance (TEER) compared to OMEs with non-keratinization (N-OMEs). Constructed epithelialized OMEs with blood capillaries are useful for in vitro/ex vivo research models and oral tissue regenerative medicine. The results suggest that OMEs with oral tissue appendages are useful alternatives to animal testing and can be applied to the design of in vitro oral models that mimic human tissue organs." @default.
• W4220873629 created "2022-04-03" @default.
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• W4220873629 date "2022-01-20" @default.
• W4220873629 modified "2023-09-25" @default.
• W4220873629 title "Construction of vascularized oral mucosa equivalents using a layer-by-layer cell coating technology" @default.
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• W4220873629 doi "https://doi.org/10.5794/jjoms.68.53" @default.
• W4220873629 hasPublicationYear "2022" @default.
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