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- W4220875078 endingPage "495" @default.
- W4220875078 startingPage "495" @default.
- W4220875078 abstract "During space missions, astronauts are faced with a variety of challenges that are unique to spaceflight and that have been known to cause physiological changes in humans over a period of time. Several of these changes occur at the microbiome level, a complex ensemble of microbial communities residing in various anatomic sites of the human body, with a pivotal role in regulating the health and behavior of the host. The microbiome is essential for day-to-day physiological activities, and alterations in microbiome composition and function have been linked to various human diseases. For these reasons, understanding the impact of spaceflight and space conditions on the microbiome of astronauts is important to assess significant health risks that can emerge during long-term missions and to develop countermeasures. Here, we review various conditions that are caused by long-term space exploration and discuss the role of the microbiome in promoting or ameliorating these conditions, as well as space-related factors that impact microbiome composition. The topics explored pertain to microgravity, radiation, immunity, bone health, cognitive function, gender differences and pharmacomicrobiomics. Connections are made between the trifecta of spaceflight, the host and the microbiome, and the significance of these interactions for successful long-term space missions." @default.
- W4220875078 created "2022-04-03" @default.
- W4220875078 creator A5038866462 @default.
- W4220875078 creator A5046795836 @default.
- W4220875078 creator A5067372265 @default.
- W4220875078 creator A5090344796 @default.
- W4220875078 date "2022-03-28" @default.
- W4220875078 modified "2023-10-09" @default.
- W4220875078 title "Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions" @default.
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