Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220876150> ?p ?o ?g. }
- W4220876150 endingPage "107173" @default.
- W4220876150 startingPage "107173" @default.
- W4220876150 abstract "So far, the human health impacts of nano- and microplastics are poorly understood. Thus, we investigated whether nanoplastics exposure induces inflammatory processes in primary human monocytes and monocyte-derived dendritic cells. We exposed these cells in vitro to nanoplastics of different shapes (irregular vs. spherical), sizes (50-310 nm and polydisperse mixtures) and polymer types (polystyrene; polymethyl methacrylate; polyvinyl chloride, PVC) using concentrations of 30-300 particles cell-1. Our results show that irregular PVC particles induce the strongest cytokine release of these nanoplastics. Irregular polystyrene triggered a significantly higher pro-inflammatory response compared to spherical nanoplastics. The contribution of chemicals leaching from the particles was minor. The effects were concentration-dependent but varied markedly between cell donors. We conclude that nanoplastics exposure can provoke human immune cells to secrete cytokines as key initiators of inflammation. This response is specific to certain polymers (PVC) and particle shapes (fragments). Accordingly, nanoplastics cannot be considered one homogenous entity when assessing their health implications and the use of spherical polystyrene nanoplastics may underestimate their inflammatory effects." @default.
- W4220876150 created "2022-04-03" @default.
- W4220876150 creator A5002018691 @default.
- W4220876150 creator A5011043607 @default.
- W4220876150 creator A5020842159 @default.
- W4220876150 creator A5053389454 @default.
- W4220876150 creator A5070564455 @default.
- W4220876150 creator A5073589118 @default.
- W4220876150 creator A5079391879 @default.
- W4220876150 creator A5089885485 @default.
- W4220876150 date "2022-05-01" @default.
- W4220876150 modified "2023-10-12" @default.
- W4220876150 title "Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells" @default.
- W4220876150 cites W1968090295 @default.
- W4220876150 cites W1968819436 @default.
- W4220876150 cites W1968865208 @default.
- W4220876150 cites W1977621013 @default.
- W4220876150 cites W1981975619 @default.
- W4220876150 cites W1990258307 @default.
- W4220876150 cites W1995704440 @default.
- W4220876150 cites W1996413994 @default.
- W4220876150 cites W2000385658 @default.
- W4220876150 cites W2016213623 @default.
- W4220876150 cites W2032751507 @default.
- W4220876150 cites W2034118909 @default.
- W4220876150 cites W2053917902 @default.
- W4220876150 cites W2055765270 @default.
- W4220876150 cites W2062835892 @default.
- W4220876150 cites W2068562565 @default.
- W4220876150 cites W2068645319 @default.
- W4220876150 cites W2076241511 @default.
- W4220876150 cites W2081683723 @default.
- W4220876150 cites W2089716915 @default.
- W4220876150 cites W2090180191 @default.
- W4220876150 cites W2096084828 @default.
- W4220876150 cites W2100775911 @default.
- W4220876150 cites W2109726944 @default.
- W4220876150 cites W2115312595 @default.
- W4220876150 cites W2116660863 @default.
- W4220876150 cites W2125123295 @default.
- W4220876150 cites W2126726099 @default.
- W4220876150 cites W2142233319 @default.
- W4220876150 cites W2145364955 @default.
- W4220876150 cites W2155349759 @default.
- W4220876150 cites W2169542790 @default.
- W4220876150 cites W2191654227 @default.
- W4220876150 cites W221027302 @default.
- W4220876150 cites W2287229750 @default.
- W4220876150 cites W2343896111 @default.
- W4220876150 cites W2503687255 @default.
- W4220876150 cites W2504484095 @default.
- W4220876150 cites W2522489726 @default.
- W4220876150 cites W2565282363 @default.
- W4220876150 cites W2588595198 @default.
- W4220876150 cites W2620099204 @default.
- W4220876150 cites W270852085 @default.
- W4220876150 cites W2753429148 @default.
- W4220876150 cites W2776544319 @default.
- W4220876150 cites W2793828865 @default.
- W4220876150 cites W2809418529 @default.
- W4220876150 cites W2901712140 @default.
- W4220876150 cites W2908304050 @default.
- W4220876150 cites W2914014612 @default.
- W4220876150 cites W2929428587 @default.
- W4220876150 cites W2936438628 @default.
- W4220876150 cites W2948574679 @default.
- W4220876150 cites W2960474960 @default.
- W4220876150 cites W2965507285 @default.
- W4220876150 cites W3021005709 @default.
- W4220876150 cites W3081774540 @default.
- W4220876150 cites W3157443957 @default.
- W4220876150 cites W4245716431 @default.
- W4220876150 cites W4248534825 @default.
- W4220876150 cites W65922439 @default.
- W4220876150 doi "https://doi.org/10.1016/j.envint.2022.107173" @default.
- W4220876150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35303527" @default.
- W4220876150 hasPublicationYear "2022" @default.
- W4220876150 type Work @default.
- W4220876150 citedByCount "33" @default.
- W4220876150 countsByYear W42208761502022 @default.
- W4220876150 countsByYear W42208761502023 @default.
- W4220876150 crossrefType "journal-article" @default.
- W4220876150 hasAuthorship W4220876150A5002018691 @default.
- W4220876150 hasAuthorship W4220876150A5011043607 @default.
- W4220876150 hasAuthorship W4220876150A5020842159 @default.
- W4220876150 hasAuthorship W4220876150A5053389454 @default.
- W4220876150 hasAuthorship W4220876150A5070564455 @default.
- W4220876150 hasAuthorship W4220876150A5073589118 @default.
- W4220876150 hasAuthorship W4220876150A5079391879 @default.
- W4220876150 hasAuthorship W4220876150A5089885485 @default.
- W4220876150 hasBestOaLocation W42208761501 @default.
- W4220876150 hasConcept C12554922 @default.
- W4220876150 hasConcept C178790620 @default.
- W4220876150 hasConcept C185592680 @default.
- W4220876150 hasConcept C202751555 @default.
- W4220876150 hasConcept C203014093 @default.
- W4220876150 hasConcept C2776866176 @default.
- W4220876150 hasConcept C2776914184 @default.