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- W4220876475 endingPage "930" @default.
- W4220876475 startingPage "913" @default.
- W4220876475 abstract "Sexual dysfunction (SD) is a symptom of depression in ≈70% of patients presenting with major depressive disorder (MDD). Antidepressant medications (AD) and adjunctive treatments may further contribute to SD and complicate evaluation and management.A systematic literature search of PubMed, Ovid MEDLINE and Cochrane databases for MDD, SD, classes of antidepressants, etc. was performed with a focus on 2014 to June 2021. SSRIs are associated with 70% treatment-emergent sexual dysfunction (TESD), SNRIs and tricyclics have rates of TESD of 40-45%, and antidepressant medications without SRI effects or with additional unique mechanisms of action have rates similar to placebo (<10%). Appropriate assessment at baseline and throughout treatment, consideration of patient preferences in prescribing, addressing modifiable factors (comorbid medical/psychiatric conditions, substances, relationship difficulties), and utilizing management strategies of switching to an AD with less SD, adding an antidote/adjunctive therapy or lowering the dose are discussed.MDD and antidepressant treatment contribute to SD in a high percentage of patients. Treating to remission reduces SD as a symptom of depression. Frequent assessment and targeted management strategies may be effective in preventing or addressing SD. Secondary outcomes like impact on adherence, relationships and self-image should also be considered." @default.
- W4220876475 created "2022-04-03" @default.
- W4220876475 creator A5012768403 @default.
- W4220876475 creator A5020411288 @default.
- W4220876475 creator A5020995037 @default.
- W4220876475 creator A5072854024 @default.
- W4220876475 date "2022-04-19" @default.
- W4220876475 modified "2023-10-13" @default.
- W4220876475 title "Sexual dysfunction with major depressive disorder and antidepressant treatments: impact, assessment, and management" @default.
- W4220876475 cites W1218291158 @default.
- W4220876475 cites W1600990718 @default.
- W4220876475 cites W1661382262 @default.
- W4220876475 cites W1701150449 @default.
- W4220876475 cites W1775862118 @default.
- W4220876475 cites W1917104769 @default.
- W4220876475 cites W1918276104 @default.
- W4220876475 cites W1928942751 @default.
- W4220876475 cites W1966669480 @default.
- W4220876475 cites W1973323394 @default.
- W4220876475 cites W1973868372 @default.
- W4220876475 cites W1976410377 @default.
- W4220876475 cites W1980004364 @default.
- W4220876475 cites W1980214648 @default.
- W4220876475 cites W1982665253 @default.
- W4220876475 cites W1982668778 @default.
- W4220876475 cites W1982880546 @default.
- W4220876475 cites W1983176528 @default.
- W4220876475 cites W1985169466 @default.
- W4220876475 cites W1985356274 @default.
- W4220876475 cites W1986573111 @default.
- W4220876475 cites W1986995464 @default.
- W4220876475 cites W1987560991 @default.
- W4220876475 cites W1989446771 @default.
- W4220876475 cites W1992493700 @default.
- W4220876475 cites W1997655814 @default.
- W4220876475 cites W1999253765 @default.
- W4220876475 cites W1999473072 @default.
- W4220876475 cites W2002724710 @default.
- W4220876475 cites W2003398316 @default.
- W4220876475 cites W2005470536 @default.
- W4220876475 cites W2005537278 @default.
- W4220876475 cites W2005648100 @default.
- W4220876475 cites W2009254360 @default.
- W4220876475 cites W2009284028 @default.
- W4220876475 cites W2016716261 @default.
- W4220876475 cites W2017191415 @default.
- W4220876475 cites W2018860882 @default.
- W4220876475 cites W2022984394 @default.
- W4220876475 cites W2023452192 @default.
- W4220876475 cites W2026328348 @default.
- W4220876475 cites W2036141199 @default.
- W4220876475 cites W2043980463 @default.
- W4220876475 cites W2051391551 @default.
- W4220876475 cites W2053575029 @default.
- W4220876475 cites W2055753888 @default.
- W4220876475 cites W2056201018 @default.
- W4220876475 cites W2061109900 @default.
- W4220876475 cites W2061519055 @default.
- W4220876475 cites W2068655027 @default.
- W4220876475 cites W2071169400 @default.
- W4220876475 cites W2072138522 @default.
- W4220876475 cites W2072988119 @default.
- W4220876475 cites W2073741345 @default.
- W4220876475 cites W2075411654 @default.
- W4220876475 cites W2076023426 @default.
- W4220876475 cites W2076391934 @default.
- W4220876475 cites W2084113489 @default.
- W4220876475 cites W2086107053 @default.
- W4220876475 cites W2090105521 @default.
- W4220876475 cites W2092497010 @default.
- W4220876475 cites W2095540310 @default.
- W4220876475 cites W2095639100 @default.
- W4220876475 cites W2096064358 @default.
- W4220876475 cites W2096527989 @default.
- W4220876475 cites W2101170150 @default.
- W4220876475 cites W2108748253 @default.
- W4220876475 cites W2110227939 @default.
- W4220876475 cites W2126074061 @default.
- W4220876475 cites W2126136540 @default.
- W4220876475 cites W2136137449 @default.
- W4220876475 cites W2136514278 @default.
- W4220876475 cites W2137004591 @default.
- W4220876475 cites W2139890332 @default.
- W4220876475 cites W2141662431 @default.
- W4220876475 cites W2143049395 @default.
- W4220876475 cites W2143089289 @default.
- W4220876475 cites W2144307786 @default.
- W4220876475 cites W2145911019 @default.
- W4220876475 cites W2149678354 @default.
- W4220876475 cites W2151437437 @default.
- W4220876475 cites W2151592453 @default.
- W4220876475 cites W2152069111 @default.
- W4220876475 cites W2155855707 @default.
- W4220876475 cites W2159201105 @default.
- W4220876475 cites W2159844955 @default.
- W4220876475 cites W2160412761 @default.
- W4220876475 cites W2163336650 @default.
- W4220876475 cites W2164182651 @default.