FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220879355> ?p ?o ?g. }

• W4220879355 endingPage "77" @default.
• W4220879355 startingPage "71" @default.
• W4220879355 abstract "As the most commonly used FVIII concentrate in China, the individualized pharmacokinetics (PK) and clinical outcomes of Kovaltry (BAY81-8973) are not fully investigated in this population.Pediatric patients with severe hemophilia A were enrolled in Beijing Children's Hospital. After a three-day washout, they received PK tests after a single-dose infusion of 50 IU/kg. The blood samples were collected with a six-point assay. One-stage-based activated partial thromboplastin time was used for FVIII activity. The PK parameters were generated by WinNonlin software. The bleeding rates were calculated by their routine therapy record. The ultrasound was used to evaluate their both sides of knees, elbows and ankles.Sixty-one boys with severe hemophilia A were enrolled and their median age was 5.73 years. Twenty-nine of them were blood group-O. Compared with blood group-O patients, those non-O patients showed longer t1/2 (15.26 vs. 13.03 h, P < 0.001) and reduced CL (3.04 vs. 3.66 mL/kg/h, P < 0.05). Patients with higher VWF:Ag level had longer half-life time (t1/2) (r = 0.60, P < 0.0001) and lower clearance (CL) (r = -0.45, P < 0.001). Patients with higher trough level showed decreased bleeding rates compared with those owning a trough level below 1 IU/dL (P < 0.05). In general, the zero bleeding rates raised with elevation of trough level. However, 20-30% of patients with low trough level (<1 IU/dL) also showed no bleeds and 10-20% of patients with high trough level (>5 IU/dL) still suffer bleeds. An inconsistency of 28% between joint bleeds and ultrasound evaluation was showed.This study revealed the great inter-individual variability in PK parameters, clinical bleeding phenotype and joint vulnerability, which all should be considered in treating hemophilia A." @default.
• W4220879355 created "2022-04-03" @default.
• W4220879355 creator A5003642180 @default.
• W4220879355 creator A5010811494 @default.
• W4220879355 creator A5017712497 @default.
• W4220879355 creator A5018291401 @default.
• W4220879355 creator A5056560444 @default.
• W4220879355 creator A5064271606 @default.
• W4220879355 creator A5066394101 @default.
• W4220879355 creator A5074942308 @default.
• W4220879355 date "2022-05-01" @default.
• W4220879355 modified "2023-10-17" @default.
• W4220879355 title "Inter-individual variability in pharmacokinetics and clinical features in pediatric patients with severe hemophilia A" @default.
• W4220879355 cites W1481832402 @default.
• W4220879355 cites W1566919421 @default.
• W4220879355 cites W1586981128 @default.
• W4220879355 cites W1599667011 @default.
• W4220879355 cites W1678213225 @default.
• W4220879355 cites W1895185717 @default.
• W4220879355 cites W1968700823 @default.
• W4220879355 cites W2006216288 @default.
• W4220879355 cites W2014705050 @default.
• W4220879355 cites W2019031926 @default.
• W4220879355 cites W2022951926 @default.
• W4220879355 cites W2060289127 @default.
• W4220879355 cites W2072493867 @default.
• W4220879355 cites W2076845477 @default.
• W4220879355 cites W2088686527 @default.
• W4220879355 cites W2093390545 @default.
• W4220879355 cites W2104523338 @default.
• W4220879355 cites W2110333348 @default.
• W4220879355 cites W2121267238 @default.
• W4220879355 cites W2122398779 @default.
• W4220879355 cites W2122846455 @default.
• W4220879355 cites W2133535613 @default.
• W4220879355 cites W2148260445 @default.
• W4220879355 cites W2167801052 @default.
• W4220879355 cites W2517992294 @default.
• W4220879355 cites W2607714781 @default.
• W4220879355 cites W2619778077 @default.
• W4220879355 cites W2804969681 @default.
• W4220879355 cites W2805031138 @default.
• W4220879355 cites W2809265551 @default.
• W4220879355 cites W2924347855 @default.
• W4220879355 cites W2943590175 @default.
• W4220879355 cites W2966646582 @default.
• W4220879355 cites W2998097899 @default.
• W4220879355 cites W3021084420 @default.
• W4220879355 cites W3023045473 @default.
• W4220879355 cites W3047046471 @default.
• W4220879355 cites W3096939226 @default.
• W4220879355 cites W3135804611 @default.
• W4220879355 cites W3138067909 @default.
• W4220879355 cites W3181527431 @default.
• W4220879355 doi "https://doi.org/10.1016/j.thromres.2022.03.008" @default.
• W4220879355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35305529" @default.
• W4220879355 hasPublicationYear "2022" @default.
• W4220879355 type Work @default.
• W4220879355 citedByCount "3" @default.
• W4220879355 countsByYear W42208793552022 @default.
• W4220879355 crossrefType "journal-article" @default.
• W4220879355 hasAuthorship W4220879355A5003642180 @default.
• W4220879355 hasAuthorship W4220879355A5010811494 @default.
• W4220879355 hasAuthorship W4220879355A5017712497 @default.
• W4220879355 hasAuthorship W4220879355A5018291401 @default.
• W4220879355 hasAuthorship W4220879355A5056560444 @default.
• W4220879355 hasAuthorship W4220879355A5064271606 @default.
• W4220879355 hasAuthorship W4220879355A5066394101 @default.
• W4220879355 hasAuthorship W4220879355A5074942308 @default.
• W4220879355 hasConcept C112705442 @default.
• W4220879355 hasConcept C126322002 @default.
• W4220879355 hasConcept C141071460 @default.
• W4220879355 hasConcept C2778261982 @default.
• W4220879355 hasConcept C2778382381 @default.
• W4220879355 hasConcept C2780434524 @default.
• W4220879355 hasConcept C2908647359 @default.
• W4220879355 hasConcept C2910800852 @default.
• W4220879355 hasConcept C71924100 @default.
• W4220879355 hasConcept C90924648 @default.
• W4220879355 hasConcept C99454951 @default.
• W4220879355 hasConceptScore W4220879355C112705442 @default.
• W4220879355 hasConceptScore W4220879355C126322002 @default.
• W4220879355 hasConceptScore W4220879355C141071460 @default.
• W4220879355 hasConceptScore W4220879355C2778261982 @default.
• W4220879355 hasConceptScore W4220879355C2778382381 @default.
• W4220879355 hasConceptScore W4220879355C2780434524 @default.
• W4220879355 hasConceptScore W4220879355C2908647359 @default.
• W4220879355 hasConceptScore W4220879355C2910800852 @default.
• W4220879355 hasConceptScore W4220879355C71924100 @default.
• W4220879355 hasConceptScore W4220879355C90924648 @default.
• W4220879355 hasConceptScore W4220879355C99454951 @default.
• W4220879355 hasLocation W42208793551 @default.
• W4220879355 hasLocation W42208793552 @default.
• W4220879355 hasOpenAccess W4220879355 @default.
• W4220879355 hasPrimaryLocation W42208793551 @default.
• W4220879355 hasRelatedWork W1857288271 @default.
• W4220879355 hasRelatedWork W1972266366 @default.
• W4220879355 hasRelatedWork W2029341269 @default.

• next