FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220879404> ?p ?o ?g. }

• W4220879404 endingPage "120" @default.
• W4220879404 startingPage "91" @default.
• W4220879404 abstract "Our modern era is witnessing an increasing infertility rate worldwide. Although some of the causes can be attributed to our modern lifestyle (e.g., persistent organic pollutants, late pregnancy), our knowledge of the human ovarian tissue has remained limited and insufficient to reverse the infertility statistics. Indeed, all efforts have been focused on the endocrine and cellular function in support of the cell theory that dates back to the 18th century, while the human ovarian matrisome is still under-described. Hereby, we unveil the extracellular side of the story during different periods of the ovary life, demonstrating that follicle survival and development, and ultimately fertility, would not be possible without its involvement. We examined the human ovarian matrisome and described its remodeling from prepuberty until menopause, creating the first ovarian proteomic codex. Here, we confidently identified and quantified 98 matrisome proteins present in the three ovary groups. Among them, 26 were expressed differently among age groups, delineating a peculiar matrisomal fingerprint at each stage. Such proteins could be potential biomarkers phenotyping ovarian ECM at each age phase of female reproductive life. Beyond proteomics, our study presents a unique approach to understanding the data and depicting the spatiotemporal ECM-intracellular signaling networks and remodeling with age through imaging, advanced text-mining based on natural language processing technology, machine learning, and data sonification. Our findings provide essential context for healthy ovarian physiology, identifying and characterizing disease states, and recapitulating physiological tissues or development in vitro. This comprehensive proteomics analysis represents the ovarian proteomic codex and contributes to an improved understanding of the critical roles that ECM plays throughout the ovarian life span." @default.
• W4220879404 created "2022-04-03" @default.
• W4220879404 creator A5002189743 @default.
• W4220879404 creator A5019290125 @default.
• W4220879404 creator A5027204791 @default.
• W4220879404 creator A5031693924 @default.
• W4220879404 creator A5034830269 @default.
• W4220879404 creator A5036421912 @default.
• W4220879404 creator A5040498940 @default.
• W4220879404 creator A5043616099 @default.
• W4220879404 creator A5052683253 @default.
• W4220879404 creator A5059868366 @default.
• W4220879404 creator A5063078389 @default.
• W4220879404 creator A5079609985 @default.
• W4220879404 creator A5080509739 @default.
• W4220879404 creator A5083678845 @default.
• W4220879404 date "2022-05-01" @default.
• W4220879404 modified "2023-09-27" @default.
• W4220879404 title "Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility" @default.
• W4220879404 cites W1533963550 @default.
• W4220879404 cites W1562057159 @default.
• W4220879404 cites W1964888681 @default.
• W4220879404 cites W1967490869 @default.
• W4220879404 cites W1976348790 @default.
• W4220879404 cites W1980439394 @default.
• W4220879404 cites W1981477005 @default.
• W4220879404 cites W1989826224 @default.
• W4220879404 cites W1993317008 @default.
• W4220879404 cites W1998505505 @default.
• W4220879404 cites W2000212544 @default.
• W4220879404 cites W2005527513 @default.
• W4220879404 cites W2007694234 @default.
• W4220879404 cites W2009298572 @default.
• W4220879404 cites W2012209215 @default.
• W4220879404 cites W2014091868 @default.
• W4220879404 cites W2017626686 @default.
• W4220879404 cites W2019433320 @default.
• W4220879404 cites W2028305872 @default.
• W4220879404 cites W2048261705 @default.
• W4220879404 cites W2063284869 @default.
• W4220879404 cites W2065539371 @default.
• W4220879404 cites W2070811113 @default.
• W4220879404 cites W2070893829 @default.
• W4220879404 cites W2088780763 @default.
• W4220879404 cites W2093096968 @default.
• W4220879404 cites W2094314608 @default.
• W4220879404 cites W2098271722 @default.
• W4220879404 cites W2098411718 @default.
• W4220879404 cites W2102308599 @default.
• W4220879404 cites W2102895407 @default.
• W4220879404 cites W2107584289 @default.
• W4220879404 cites W2110280725 @default.
• W4220879404 cites W2115826572 @default.
• W4220879404 cites W2121897688 @default.
• W4220879404 cites W2122685595 @default.
• W4220879404 cites W2124556975 @default.
• W4220879404 cites W2125048296 @default.
• W4220879404 cites W2127048118 @default.
• W4220879404 cites W2137779899 @default.
• W4220879404 cites W2140601463 @default.
• W4220879404 cites W2143444700 @default.
• W4220879404 cites W2146233092 @default.
• W4220879404 cites W2150214114 @default.
• W4220879404 cites W2152512428 @default.
• W4220879404 cites W2152684480 @default.
• W4220879404 cites W2155428290 @default.
• W4220879404 cites W2156091968 @default.
• W4220879404 cites W2157862249 @default.
• W4220879404 cites W2165233863 @default.
• W4220879404 cites W2315512556 @default.
• W4220879404 cites W2318488323 @default.
• W4220879404 cites W2338110434 @default.
• W4220879404 cites W2497766038 @default.
• W4220879404 cites W2541894784 @default.
• W4220879404 cites W2588856216 @default.
• W4220879404 cites W2592758270 @default.
• W4220879404 cites W2596139865 @default.
• W4220879404 cites W2607434574 @default.
• W4220879404 cites W2776039042 @default.
• W4220879404 cites W2790100212 @default.
• W4220879404 cites W2792793586 @default.
• W4220879404 cites W2886452253 @default.
• W4220879404 cites W2899760200 @default.
• W4220879404 cites W2903464283 @default.
• W4220879404 cites W2907453472 @default.
• W4220879404 cites W2912567453 @default.
• W4220879404 cites W2913368570 @default.
• W4220879404 cites W2914133736 @default.
• W4220879404 cites W2962680130 @default.
• W4220879404 cites W2966096825 @default.
• W4220879404 cites W2976479159 @default.
• W4220879404 cites W2978493452 @default.
• W4220879404 cites W2979685247 @default.
• W4220879404 cites W2988893955 @default.
• W4220879404 cites W3004127014 @default.
• W4220879404 cites W3028245480 @default.
• W4220879404 cites W3032745436 @default.
• W4220879404 cites W3034113897 @default.

• next