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- W4220881466 abstract "Abstract Circular RNAs (circRNAs) are produced by head-to-tail back-splicing which is mainly facilitated by base-pairing of reverse complementary matches (RCMs) in circRNA flanking introns. Adenosine deaminases acting on RNA (ADARs) are known to bind double-stranded RNAs for adenosine to inosine (A-to-I) RNA editing. Here we characterize ADARs as potent regulators of circular transcriptome by identifying over a thousand of circRNAs regulated by ADARs in a bidirectional manner through and beyond their editing function. We find that editing can stabilize or destabilize secondary structures formed between RCMs via correcting A:C mismatches to I(G)-C pairs or creating I(G).U wobble pairs, respectively. We provide experimental evidence that editing also favors the binding of RNA-binding proteins such as PTBP1 to regulate back-splicing. These ADARs-regulated circRNAs which are ubiquitously expressed in multiple types of cancers, demonstrate high functional relevance to cancer. Our findings support a hitherto unappreciated bidirectional regulation of circular transcriptome by ADARs and highlight the complexity of cross-talk in RNA processing and its contributions to tumorigenesis." @default.
- W4220881466 created "2022-04-03" @default.
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- W4220881466 date "2022-03-21" @default.
- W4220881466 modified "2023-10-18" @default.
- W4220881466 title "ADARs act as potent regulators of circular transcriptome in cancer" @default.
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- W4220881466 doi "https://doi.org/10.1038/s41467-022-29138-2" @default.
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- W4220881466 hasPublicationYear "2022" @default.
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