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- W4220883145 abstract "Pregnant women represent a uniquely vulnerable population during an infectious disease outbreak, such as the COVID-19 pandemic. Although we are at the early stages of understanding the specific impact of SARS-CoV-2 exposure during pregnancy, mounting epidemiological evidence strongly supports a link between exposure to a variety of maternal infections and an increased risk for offspring neurodevelopmental disorders. Inflammatory biomarkers identified from archived or prospectively collected maternal biospecimens suggest that the maternal immune response is the critical link between infection during pregnancy and altered offspring neurodevelopment. This maternal immune activation (MIA) hypothesis has been tested in animal models by artificially activating the immune system during pregnancy and evaluating the neurodevelopmental consequences in MIA-exposed offspring. Although the vast majority of MIA model research is carried out in rodents, the nonhuman primate model has emerged in recent years as an important translational tool. In this review, we briefly summarize human epidemiological studies that have prompted the development of translationally relevant MIA models. We then highlight notable similarities between humans and nonhuman primates, including placental structure, pregnancy physiology, gestational timelines, and offspring neurodevelopmental stages, that provide an opportunity to explore the MIA hypothesis in species more closely related to humans. Finally, we provide a comprehensive review of neurodevelopmental alterations reported in current nonhuman primate models of maternal infection and discuss future directions for this promising area of research." @default.
- W4220883145 created "2022-04-03" @default.
- W4220883145 creator A5027549476 @default.
- W4220883145 creator A5083081729 @default.
- W4220883145 date "2022-05-01" @default.
- W4220883145 modified "2023-09-26" @default.
- W4220883145 title "Primate Models as a Translational Tool for Understanding Prenatal Origins of Neurodevelopmental Disorders Associated With Maternal Infection" @default.
- W4220883145 cites W127650315 @default.
- W4220883145 cites W1496165357 @default.
- W4220883145 cites W1498791230 @default.
- W4220883145 cites W1555182204 @default.
- W4220883145 cites W1792338879 @default.
- W4220883145 cites W1841261356 @default.
- W4220883145 cites W1943382614 @default.
- W4220883145 cites W1964371761 @default.
- W4220883145 cites W1964508173 @default.
- W4220883145 cites W1966407955 @default.
- W4220883145 cites W1971916575 @default.
- W4220883145 cites W1972968697 @default.
- W4220883145 cites W1973408086 @default.
- W4220883145 cites W1977348028 @default.
- W4220883145 cites W1978929144 @default.
- W4220883145 cites W1979504905 @default.
- W4220883145 cites W1982693223 @default.
- W4220883145 cites W1988666576 @default.
- W4220883145 cites W1990999239 @default.
- W4220883145 cites W1992991337 @default.
- W4220883145 cites W1993985496 @default.
- W4220883145 cites W1994600097 @default.
- W4220883145 cites W1996903344 @default.
- W4220883145 cites W1999221289 @default.
- W4220883145 cites W2002833038 @default.
- W4220883145 cites W2010570746 @default.
- W4220883145 cites W2016950750 @default.
- W4220883145 cites W2017113698 @default.
- W4220883145 cites W2020114463 @default.
- W4220883145 cites W2020651859 @default.
- W4220883145 cites W2021906711 @default.
- W4220883145 cites W2022686960 @default.
- W4220883145 cites W2024510213 @default.
- W4220883145 cites W2027716792 @default.
- W4220883145 cites W2028369131 @default.
- W4220883145 cites W2029583275 @default.
- W4220883145 cites W2033880528 @default.
- W4220883145 cites W2034041811 @default.
- W4220883145 cites W2037555832 @default.
- W4220883145 cites W2040408325 @default.
- W4220883145 cites W2042410372 @default.
- W4220883145 cites W2045753421 @default.
- W4220883145 cites W2048843644 @default.
- W4220883145 cites W2051802682 @default.
- W4220883145 cites W2052277426 @default.
- W4220883145 cites W2052610531 @default.
- W4220883145 cites W2053032438 @default.
- W4220883145 cites W2053261697 @default.
- W4220883145 cites W2057521565 @default.
- W4220883145 cites W2059242143 @default.
- W4220883145 cites W2064176741 @default.
- W4220883145 cites W2067416991 @default.
- W4220883145 cites W2069288713 @default.
- W4220883145 cites W2070936810 @default.
- W4220883145 cites W2071732363 @default.
- W4220883145 cites W2073112359 @default.
- W4220883145 cites W2074482242 @default.
- W4220883145 cites W2081161499 @default.
- W4220883145 cites W2084450750 @default.
- W4220883145 cites W2089224748 @default.
- W4220883145 cites W2092196742 @default.
- W4220883145 cites W2092305484 @default.
- W4220883145 cites W2092931973 @default.
- W4220883145 cites W2101795920 @default.
- W4220883145 cites W2104000439 @default.
- W4220883145 cites W2105035544 @default.
- W4220883145 cites W2108236821 @default.
- W4220883145 cites W2113207193 @default.
- W4220883145 cites W2119799034 @default.
- W4220883145 cites W2120701088 @default.
- W4220883145 cites W2123997849 @default.
- W4220883145 cites W2125244470 @default.
- W4220883145 cites W2125343575 @default.
- W4220883145 cites W2125706509 @default.
- W4220883145 cites W2130793535 @default.
- W4220883145 cites W2137386978 @default.
- W4220883145 cites W2139281694 @default.
- W4220883145 cites W2143217444 @default.
- W4220883145 cites W2152625378 @default.
- W4220883145 cites W2153129892 @default.
- W4220883145 cites W2154965665 @default.
- W4220883145 cites W2155471406 @default.
- W4220883145 cites W2155687571 @default.
- W4220883145 cites W2155933706 @default.
- W4220883145 cites W2161702388 @default.
- W4220883145 cites W2163146602 @default.
- W4220883145 cites W2163759450 @default.
- W4220883145 cites W2167272363 @default.
- W4220883145 cites W2170260565 @default.
- W4220883145 cites W2174739469 @default.
- W4220883145 cites W2337955410 @default.