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- W4220883830 abstract "PRDM9 is a key regulator of meiotic recombination in most metazoans, responsible for reshuffling parental genomes. During meiosis, the PRDM9 protein recognizes and binds specific target motifs via its array of C2H2 zinc-fingers encoded by a rapidly evolving minisatellite. The gene coding for PRDM9 is the only speciation gene identified in vertebrates to date and shows high variation, particularly in the DNA-recognizing positions of the zinc-finger array, within and between species. Across all vertebrate genomes studied for PRDM9 evolution, only one genome lacks variability between repeat types - that of the North Pacific minke whale. This study aims to understand the evolution and diversity of Prdm9 in minke whales, which display the most unusual genome reference allele of Prdm9 so far discovered in mammals.Minke whales possess all the features characteristic of PRDM9-directed recombination, including complete KRAB, SSXRD and SET domains and a rapidly evolving array of C2H2-type-Zincfingers (ZnF) with evidence of rapid evolution, particularly at DNA-recognizing positions that evolve under positive diversifying selection. Seventeen novel PRDM9 variants were identified within the Antarctic minke whale species, plus a single distinct PRDM9 variant in Common minke whales - shared across North Atlantic and North Pacific minke whale subspecies boundaries.The PRDM9 ZnF array evolves rapidly, in minke whales, with at least one DNA-recognizing position under positive selection. Extensive PRDM9 diversity is observed, particularly in the Antarctic in minke whales. Common minke whales shared a specific Prdm9 allele across subspecies boundaries, suggesting incomplete speciation by the mechanisms associated with PRDM9 hybrid sterility." @default.
- W4220883830 created "2022-04-03" @default.
- W4220883830 creator A5033175802 @default.
- W4220883830 creator A5057285365 @default.
- W4220883830 creator A5057691810 @default.
- W4220883830 creator A5078927767 @default.
- W4220883830 date "2022-03-16" @default.
- W4220883830 modified "2023-10-18" @default.
- W4220883830 title "Evolution of the recombination regulator PRDM9 in minke whales" @default.
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- W4220883830 doi "https://doi.org/10.1186/s12864-022-08305-1" @default.
- W4220883830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35296233" @default.
- W4220883830 hasPublicationYear "2022" @default.
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