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- W4220885334 abstract "Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of neuroendocrine origin. Several epidemiological studies have demonstrated a strong association between MCC and ultraviolet (UV) radiation. The discovery of the MC polyomavirus (MCV) and its subsequent detection in the majority of MCC cases provided additional insight into tumor pathogenesis. Clinical findings in MCC are relatively non-specific, but the tumor displays an aggressive clinical behavior, with high rates of local recurrence and nodal metastasis. Surgical management remains first-line, with Mohs micrographic surgery or wide local excision with 1–2 cm margins. Adjuvant radiation should be considered as it may lower local recurrence rates, although its impact on overall survival remains unclear. Immunotherapy in the setting of advanced disease is promising, but further investigations are warranted. Prognosis remains poor despite therapeutic advances. Close monitoring of patients is therefore recommended, ideally in a multidisciplinary setting, owing to the tumor’s highly aggressive clinical behavior. The following cases demonstrate different treatment approaches to the different stages of MCC." @default.
- W4220885334 created "2022-04-03" @default.
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- W4220885334 date "2022-03-09" @default.
- W4220885334 modified "2023-09-30" @default.
- W4220885334 title "Merkel Cell Carcinoma" @default.
- W4220885334 doi "https://doi.org/10.1201/9780429026683-7" @default.
- W4220885334 hasPublicationYear "2022" @default.
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