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- W4220887182 abstract "The total synthesis of the depsipeptide natural product plusbacin A3 (1) utilizing solid-phase peptide synthesis (SPPS) was disclosed. A 3-hydroxy-proline derivative compatible with Fmoc SPPS was prepared by a diastereoselective Joullié-Ugi three-component reaction (JU-3CR)/hydrolysis sequence. After peptide elongation on the solid support, cleavage of the peptide from the resin, followed by macrolactamization and global deprotection, gave plusbacin A3 (1)." @default.
- W4220887182 created "2022-04-03" @default.
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- W4220887182 date "2022-03-16" @default.
- W4220887182 modified "2023-10-17" @default.
- W4220887182 title "Solid-Phase Total Synthesis of Plusbacin A<sub>3</sub>" @default.
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- W4220887182 doi "https://doi.org/10.1021/acs.orglett.2c00667" @default.
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