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- W4220888235 endingPage "654" @default.
- W4220888235 startingPage "654" @default.
- W4220888235 abstract "The treatment of psoriasis has been revolutionized by the emergence of biological therapies. Monoclonal antibodies (mAb) generally have complex pharmacokinetic (PK) properties with nonlinear distribution and elimination. In recent years, several population pharmacokinetic/pharmacodynamic (PK/PD) models capable of describing different types of mAb have been published. This study aims to summarize the findings of a literature search about population PK/PD modeling and therapeutic drug monitoring (TDM) of mAb in psoriasis. A total of 22 articles corresponding to population PK/PD models of tumor necrosis factor (TNF)-α inhibitors (adalimumab and golimumab), interleukin (IL)-23 inhibitors (guselkumab, tildrakizumab, and risankizumab), IL-23/IL-12 inhibitor (ustekinumab), and IL-17 inhibitors (secukinumab, ixekizumab, and brodalumab) were collected. A summary of the clinical trials conducted so far in psoriasis was included, together with the current structural population PK and PD models. The most significant and clinical covariates were body weight (BW) and the presence of immunogenicity on clearance (CL). The lack of consensus on PK/PD relationships has prevented establishing an adequate dosage and, therefore, accentuates the need for TDM in psoriasis." @default.
- W4220888235 created "2022-04-03" @default.
- W4220888235 creator A5005690718 @default.
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- W4220888235 creator A5069976655 @default.
- W4220888235 creator A5078729859 @default.
- W4220888235 creator A5081277496 @default.
- W4220888235 date "2022-03-16" @default.
- W4220888235 modified "2023-10-16" @default.
- W4220888235 title "Impact of Pharmacokinetic and Pharmacodynamic Properties of Monoclonal Antibodies in the Management of Psoriasis" @default.
- W4220888235 cites W1508752722 @default.
- W4220888235 cites W1536336065 @default.
- W4220888235 cites W1552422862 @default.
- W4220888235 cites W1589693489 @default.
- W4220888235 cites W1594501889 @default.
- W4220888235 cites W1602142879 @default.
- W4220888235 cites W1826301003 @default.
- W4220888235 cites W1912890439 @default.
- W4220888235 cites W1954102524 @default.
- W4220888235 cites W1955559925 @default.
- W4220888235 cites W1964481160 @default.
- W4220888235 cites W1970875728 @default.
- W4220888235 cites W1973354423 @default.
- W4220888235 cites W1975463338 @default.
- W4220888235 cites W2003372606 @default.
- W4220888235 cites W2003687140 @default.
- W4220888235 cites W2005176759 @default.
- W4220888235 cites W2006673542 @default.
- W4220888235 cites W2007010878 @default.
- W4220888235 cites W2008716526 @default.
- W4220888235 cites W2008835593 @default.
- W4220888235 cites W2011009038 @default.
- W4220888235 cites W2013361256 @default.
- W4220888235 cites W2013488106 @default.
- W4220888235 cites W2023773454 @default.
- W4220888235 cites W2024143742 @default.
- W4220888235 cites W2025012298 @default.
- W4220888235 cites W2029128580 @default.
- W4220888235 cites W2030522563 @default.
- W4220888235 cites W2033978760 @default.
- W4220888235 cites W2037006676 @default.
- W4220888235 cites W2042872568 @default.
- W4220888235 cites W2044360617 @default.
- W4220888235 cites W2045317929 @default.
- W4220888235 cites W2046800234 @default.
- W4220888235 cites W2046969318 @default.
- W4220888235 cites W2048954270 @default.
- W4220888235 cites W2055637177 @default.
- W4220888235 cites W2060546762 @default.
- W4220888235 cites W2062826169 @default.
- W4220888235 cites W2063030494 @default.
- W4220888235 cites W2063627867 @default.
- W4220888235 cites W2067933166 @default.
- W4220888235 cites W2071343804 @default.
- W4220888235 cites W2072683923 @default.
- W4220888235 cites W2078380224 @default.
- W4220888235 cites W2081482161 @default.
- W4220888235 cites W2082535104 @default.
- W4220888235 cites W2084733550 @default.
- W4220888235 cites W2088569180 @default.
- W4220888235 cites W2091442391 @default.
- W4220888235 cites W2099687194 @default.
- W4220888235 cites W2101349295 @default.
- W4220888235 cites W2103750969 @default.
- W4220888235 cites W2105609362 @default.
- W4220888235 cites W2109769327 @default.
- W4220888235 cites W2112128505 @default.
- W4220888235 cites W21125662 @default.
- W4220888235 cites W2115525058 @default.
- W4220888235 cites W2116956799 @default.
- W4220888235 cites W2119904228 @default.
- W4220888235 cites W2121019442 @default.
- W4220888235 cites W2126798127 @default.
- W4220888235 cites W2127834887 @default.
- W4220888235 cites W2129777700 @default.
- W4220888235 cites W2146843653 @default.
- W4220888235 cites W2149148432 @default.
- W4220888235 cites W2149566497 @default.
- W4220888235 cites W2151209321 @default.
- W4220888235 cites W2152262899 @default.
- W4220888235 cites W2155256428 @default.
- W4220888235 cites W2163778689 @default.
- W4220888235 cites W2166836795 @default.
- W4220888235 cites W2168505126 @default.
- W4220888235 cites W2171889601 @default.
- W4220888235 cites W2172204877 @default.
- W4220888235 cites W2172257129 @default.
- W4220888235 cites W2254747749 @default.
- W4220888235 cites W2266975693 @default.
- W4220888235 cites W2276035339 @default.
- W4220888235 cites W2317900027 @default.
- W4220888235 cites W2322390243 @default.
- W4220888235 cites W2326643498 @default.
- W4220888235 cites W2333311307 @default.
- W4220888235 cites W2418506270 @default.
- W4220888235 cites W2513132225 @default.