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• W4220888679 endingPage "108991" @default.
• W4220888679 startingPage "108991" @default.
• W4220888679 abstract "Many studies have been performed in severe COVID-19 on immune cells in the circulation and on cells obtained by bronchoalveolar lavage. Most studies have tended to provide relative information rather than a quantitative view, and it is a combination of approaches by various groups that is helping the field build a picture of the mechanisms that drive severe lung disease. Approaches employed to date have not revealed information on lung parenchymal T cell subsets in severe COVID-19. Therefore, we sought to examine early and late T cell subset alterations in the lungs and draining lymph nodes in severe COVID-19 using a rapid autopsy protocol and quantitative imaging approaches. Here, we have established that cytotoxic CD4+ T cells (CD4 + CTLs) increase in the lungs, draining lymph nodes and blood as COVID-19 progresses. CD4 + CTLs are prominently expanded in the lung parenchyma in severe COVID-19. In contrast CD8+ T cells are not prominent, exhibit increased PD-1 expression, and no obvious increase is seen in the number of Granzyme B+ CD8+ T cells in the lung parenchyma in severe COVID-19. Based on quantitative evidence for re-activation in the lung milieu, CD4 + CTLs may be as likely to drive viral clearance as CD8+ T cells and may also be contributors to lung inflammation and eventually to fibrosis in severe COVID-19." @default.
• W4220888679 created "2022-04-03" @default.
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• W4220888679 date "2022-04-01" @default.
• W4220888679 modified "2023-10-06" @default.
• W4220888679 title "Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19" @default.
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• W4220888679 doi "https://doi.org/10.1016/j.clim.2022.108991" @default.
• W4220888679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35364330" @default.
• W4220888679 hasPublicationYear "2022" @default.
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