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- W4220889712 abstract "Abstract The epigenetic patterns that are established during early thymic development might determine mature T cell physiology and function, but the molecular basis and topography of the genetic elements involved are not fully known. Here we show, using the Cd4 locus as a paradigm for early developmental programming, that DNA demethylation during thymic development licenses a novel stimulus-responsive element that is critical for the maintenance of Cd4 gene expression in effector T cells. We document the importance of maintaining high CD4 expression during parasitic infection and show that by driving transcription, this stimulus-responsive element allows for the maintenance of histone H3K4me3 levels during T cell replication, which is critical for preventing de novo DNA methylation at the Cd4 promoter. A failure to undergo epigenetic programming during development leads to gene silencing during effector T cell replication. Our study thus provides evidence of early developmental events shaping the functional fitness of mature effector T cells." @default.
- W4220889712 created "2022-04-03" @default.
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- W4220889712 date "2022-03-18" @default.
- W4220889712 modified "2023-10-07" @default.
- W4220889712 title "CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element" @default.
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- W4220889712 doi "https://doi.org/10.1038/s41467-022-28914-4" @default.
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- W4220889712 hasPublicationYear "2022" @default.
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