Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220893886> ?p ?o ?g. }
- W4220893886 abstract "The circadian system is an innate clock mechanism that governs biological processes on a near 24-hour cycle. Circadian rhythm disruption (i.e., misalignment of circadian rhythms), which results from the lack of synchrony between the master circadian clock located in the suprachiasmatic nuclei (SCN) and the environment (i.e., exposure to day light) or the master clock and the peripheral clocks, has been associated with increased risk of and unfavorable cancer outcomes. Growing evidence supports the link between circadian disruption and increased prevalence and mortality of genitourinary cancers (GU) including prostate, bladder, and renal cancer. The circadian system also plays an essential role on the timely implementation of chronopharmacological treatments, such as melatonin and chronotherapy, to reduce tumor progression, improve therapeutic response and reduce negative therapy side effects. The potential benefits of the manipulating circadian rhythms in the clinical setting of GU cancer detection and treatment remain to be exploited. In this review, we discuss the current evidence on the influence of circadian rhythms on (disease) cancer development and hope to elucidate the unmet clinical need of defining the extensive involvement of the circadian system in predicting risk for GU cancer development and alleviating the burden of implementing anti-cancer therapies." @default.
- W4220893886 created "2022-04-03" @default.
- W4220893886 creator A5009365277 @default.
- W4220893886 creator A5022000968 @default.
- W4220893886 creator A5044636554 @default.
- W4220893886 creator A5049463513 @default.
- W4220893886 creator A5087732297 @default.
- W4220893886 date "2022-03-09" @default.
- W4220893886 modified "2023-09-25" @default.
- W4220893886 title "Impact of Circadian Rhythms on the Development and Clinical Management of Genitourinary Cancers" @default.
- W4220893886 cites W114098355 @default.
- W4220893886 cites W1550675315 @default.
- W4220893886 cites W155767755 @default.
- W4220893886 cites W1585382539 @default.
- W4220893886 cites W1754760787 @default.
- W4220893886 cites W1818978306 @default.
- W4220893886 cites W1914884493 @default.
- W4220893886 cites W1941626268 @default.
- W4220893886 cites W1949446280 @default.
- W4220893886 cites W1964544156 @default.
- W4220893886 cites W1969134337 @default.
- W4220893886 cites W1972571170 @default.
- W4220893886 cites W1973655938 @default.
- W4220893886 cites W1976416008 @default.
- W4220893886 cites W1977081091 @default.
- W4220893886 cites W1985541217 @default.
- W4220893886 cites W1992726958 @default.
- W4220893886 cites W1994436521 @default.
- W4220893886 cites W1994645748 @default.
- W4220893886 cites W1997426777 @default.
- W4220893886 cites W1997994342 @default.
- W4220893886 cites W2001774474 @default.
- W4220893886 cites W2006136273 @default.
- W4220893886 cites W2006553178 @default.
- W4220893886 cites W2011460555 @default.
- W4220893886 cites W2012484330 @default.
- W4220893886 cites W2013244539 @default.
- W4220893886 cites W2015611130 @default.
- W4220893886 cites W2017078849 @default.
- W4220893886 cites W2019955714 @default.
- W4220893886 cites W2025899707 @default.
- W4220893886 cites W2029519468 @default.
- W4220893886 cites W2029781784 @default.
- W4220893886 cites W2029963374 @default.
- W4220893886 cites W2034331567 @default.
- W4220893886 cites W2040679872 @default.
- W4220893886 cites W2044407327 @default.
- W4220893886 cites W2048818643 @default.
- W4220893886 cites W2048828505 @default.
- W4220893886 cites W2057563010 @default.
- W4220893886 cites W2061769555 @default.
- W4220893886 cites W2062262581 @default.
- W4220893886 cites W2062280245 @default.
- W4220893886 cites W2068800193 @default.
- W4220893886 cites W2070183442 @default.
- W4220893886 cites W2071735670 @default.
- W4220893886 cites W2073117151 @default.
- W4220893886 cites W2073218468 @default.
- W4220893886 cites W2073590673 @default.
- W4220893886 cites W2077706065 @default.
- W4220893886 cites W2080477888 @default.
- W4220893886 cites W2080931388 @default.
- W4220893886 cites W2085856683 @default.
- W4220893886 cites W2086658907 @default.
- W4220893886 cites W2087376237 @default.
- W4220893886 cites W2089737351 @default.
- W4220893886 cites W2090310668 @default.
- W4220893886 cites W2090740247 @default.
- W4220893886 cites W2091558403 @default.
- W4220893886 cites W2111025829 @default.
- W4220893886 cites W2111045528 @default.
- W4220893886 cites W2115155004 @default.
- W4220893886 cites W2120366984 @default.
- W4220893886 cites W2121680982 @default.
- W4220893886 cites W2124291683 @default.
- W4220893886 cites W2127282382 @default.
- W4220893886 cites W2133918896 @default.
- W4220893886 cites W2137281439 @default.
- W4220893886 cites W2141037581 @default.
- W4220893886 cites W2144960550 @default.
- W4220893886 cites W2150983645 @default.
- W4220893886 cites W2155314510 @default.
- W4220893886 cites W2158107656 @default.
- W4220893886 cites W2161548459 @default.
- W4220893886 cites W2163531378 @default.
- W4220893886 cites W2163976491 @default.
- W4220893886 cites W2165539549 @default.
- W4220893886 cites W2167265027 @default.
- W4220893886 cites W2179708332 @default.
- W4220893886 cites W2231618038 @default.
- W4220893886 cites W2267810789 @default.
- W4220893886 cites W2310587650 @default.
- W4220893886 cites W2323516874 @default.
- W4220893886 cites W2340671833 @default.
- W4220893886 cites W2414641360 @default.
- W4220893886 cites W2466135415 @default.
- W4220893886 cites W2467154169 @default.
- W4220893886 cites W2473162054 @default.
- W4220893886 cites W2485924001 @default.
- W4220893886 cites W2526560619 @default.