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• W4220895368 abstract "During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases, diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs to regenerate is regulated by the primary cilium, a cellular protrusion that serves as a sensitive sensory organelle. Abolishing MuSC cilia inhibited MuSC proliferation in vitro and severely impaired injury-induced muscle regeneration in vivo. In aged muscle, a cell intrinsic defect in MuSC ciliation was associated with the decrease in regenerative capacity. Exogenous activation of Hedgehog signaling, known to be localized in the primary cilium, promoted MuSC expansion, both in vitro and in vivo. Delivery of the small molecule Smoothened agonist (SAG1.3) to muscles of aged mice restored regenerative capacity leading to increased strength post-injury. These findings provide fresh insights into the signaling dysfunction in aged MuSCs and identify the ciliary Hedgehog signaling pathway as a potential therapeutic target to counter the loss of muscle regenerative capacity which accompanies aging." @default.
• W4220895368 created "2022-04-03" @default.
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• W4220895368 date "2022-03-17" @default.
• W4220895368 modified "2023-10-12" @default.
• W4220895368 title "Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging" @default.
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• W4220895368 cites W2004754771 @default.
• W4220895368 cites W2010253303 @default.
• W4220895368 cites W2012535690 @default.
• W4220895368 cites W2012956265 @default.
• W4220895368 cites W2017075649 @default.
• W4220895368 cites W2017835956 @default.
• W4220895368 cites W2019555020 @default.
• W4220895368 cites W2020303151 @default.
• W4220895368 cites W2025957803 @default.
• W4220895368 cites W2029914169 @default.
• W4220895368 cites W2031495223 @default.
• W4220895368 cites W2044228161 @default.
• W4220895368 cites W2047018308 @default.
• W4220895368 cites W2058144592 @default.
• W4220895368 cites W2059165104 @default.
• W4220895368 cites W2059456940 @default.
• W4220895368 cites W2069943755 @default.
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• W4220895368 cites W2114268808 @default.
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• W4220895368 cites W2136002176 @default.
• W4220895368 cites W2138514622 @default.
• W4220895368 cites W2141701416 @default.
• W4220895368 cites W2146335442 @default.
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• W4220895368 cites W2169456326 @default.
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• W4220895368 cites W2230902569 @default.
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• W4220895368 cites W2345477376 @default.
• W4220895368 cites W2346077982 @default.
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• W4220895368 cites W2554199252 @default.
• W4220895368 cites W2587398364 @default.
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• W4220895368 cites W2624934173 @default.
• W4220895368 cites W2735513135 @default.
• W4220895368 cites W2755666968 @default.
• W4220895368 cites W2762986013 @default.
• W4220895368 cites W2785279167 @default.
• W4220895368 cites W2913985590 @default.
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• W4220895368 cites W2940640801 @default.
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• W4220895368 doi "https://doi.org/10.1038/s41467-022-29150-6" @default.
• W4220895368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35301320" @default.
• W4220895368 hasPublicationYear "2022" @default.
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