FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220896684> ?p ?o ?g. }

• W4220896684 endingPage "403" @default.
• W4220896684 startingPage "394" @default.
• W4220896684 abstract "Pterostilbene (PTE), a common polyphenol compound, exerts an anti-inflammatory effect in many diseases, including acute lung injury (ALI).This study explores the potential mechanism of PTE pre-treatment against lipopolysaccharide (LPS)-induced ALI.Sixty Sprague-Dawley rats were divided into control, ALI, 10 mg/kg PTE + LPS, 20 mg/kg PTE + LPS, and 40 mg/kg PTE + LPS groups. At 24 h before LPS instillation, PTE was administered orally. At 2 h before LPS instillation, PTE was again administered orally. After 24 h of LPS treatment, the rats were euthanized. The levels of inflammatory cells and inflammatory factors in the bronchoalveolar lavage fluid (BALF), the expression of nuclear receptor subfamily 4 group A member 1 (NR4A1), and the nuclear factor (NF)-κB pathway-related protein levels were detected. NR4A1 agonist was used to further investigate the mechanism of PTE pre-treatment.After PTE pre-treatment, the LPS induced inflammation was controlled and the survival rate was increased to 100% from 70% after LPS treatment 24 h. For lung injury score, it decreased to 1.5 from 3.5 after treating 40 mg/kg PTE. Compared with the control group, the expression of NR4A1 in the ALI group was decreased by 20-40%. However, the 40 mg/kg PTE pre-treatment increased the NR4A1 expression by 20-40% in the lung tissue. The results obtained with pre-treatment NR4A1 agonist were similar to those obtained by pre-treatment 40 mg/kg PTE.PTE pre-treatment might represent an appropriate therapeutic target and strategy for preventing ALI induced by LPS." @default.
• W4220896684 created "2022-04-03" @default.
• W4220896684 creator A5015968273 @default.
• W4220896684 creator A5025229762 @default.
• W4220896684 creator A5025751238 @default.
• W4220896684 creator A5034885444 @default.
• W4220896684 creator A5035064408 @default.
• W4220896684 creator A5052982162 @default.
• W4220896684 creator A5060002817 @default.
• W4220896684 creator A5079400951 @default.
• W4220896684 date "2022-03-10" @default.
• W4220896684 modified "2023-09-27" @default.
• W4220896684 title "Pterostilbene pre-treatment reduces LPS-induced acute lung injury through activating NR4A1" @default.
• W4220896684 cites W1991946138 @default.
• W4220896684 cites W2008906556 @default.
• W4220896684 cites W2009933778 @default.
• W4220896684 cites W204998232 @default.
• W4220896684 cites W2120011907 @default.
• W4220896684 cites W2126600564 @default.
• W4220896684 cites W2169673753 @default.
• W4220896684 cites W2292120344 @default.
• W4220896684 cites W2335858336 @default.
• W4220896684 cites W2369011425 @default.
• W4220896684 cites W250173798 @default.
• W4220896684 cites W2528853165 @default.
• W4220896684 cites W2560528532 @default.
• W4220896684 cites W2601985852 @default.
• W4220896684 cites W2762360150 @default.
• W4220896684 cites W2803345386 @default.
• W4220896684 cites W2889930447 @default.
• W4220896684 cites W2897139941 @default.
• W4220896684 cites W2897623665 @default.
• W4220896684 cites W2900150319 @default.
• W4220896684 cites W2901408711 @default.
• W4220896684 cites W2904045437 @default.
• W4220896684 cites W2921600023 @default.
• W4220896684 cites W2928535033 @default.
• W4220896684 cites W2971815153 @default.
• W4220896684 cites W2972520451 @default.
• W4220896684 cites W2980537802 @default.
• W4220896684 cites W2986002996 @default.
• W4220896684 cites W3012360867 @default.
• W4220896684 cites W3099909848 @default.
• W4220896684 cites W3109552892 @default.
• W4220896684 cites W3114008508 @default.
• W4220896684 cites W3127440949 @default.
• W4220896684 cites W3137022102 @default.
• W4220896684 doi "https://doi.org/10.1080/13880209.2022.2034893" @default.
• W4220896684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35271397" @default.
• W4220896684 hasPublicationYear "2022" @default.
• W4220896684 type Work @default.
• W4220896684 citedByCount "4" @default.
• W4220896684 countsByYear W42208966842023 @default.
• W4220896684 crossrefType "journal-article" @default.
• W4220896684 hasAuthorship W4220896684A5015968273 @default.
• W4220896684 hasAuthorship W4220896684A5025229762 @default.
• W4220896684 hasAuthorship W4220896684A5025751238 @default.
• W4220896684 hasAuthorship W4220896684A5034885444 @default.
• W4220896684 hasAuthorship W4220896684A5035064408 @default.
• W4220896684 hasAuthorship W4220896684A5052982162 @default.
• W4220896684 hasAuthorship W4220896684A5060002817 @default.
• W4220896684 hasAuthorship W4220896684A5079400951 @default.
• W4220896684 hasBestOaLocation W42208966841 @default.
• W4220896684 hasConcept C126322002 @default.
• W4220896684 hasConcept C170493617 @default.
• W4220896684 hasConcept C203014093 @default.
• W4220896684 hasConcept C2776816829 @default.
• W4220896684 hasConcept C2776914184 @default.
• W4220896684 hasConcept C2777714996 @default.
• W4220896684 hasConcept C2777961210 @default.
• W4220896684 hasConcept C2778754761 @default.
• W4220896684 hasConcept C2778938600 @default.
• W4220896684 hasConcept C2781196776 @default.
• W4220896684 hasConcept C71924100 @default.
• W4220896684 hasConcept C98274493 @default.
• W4220896684 hasConceptScore W4220896684C126322002 @default.
• W4220896684 hasConceptScore W4220896684C170493617 @default.
• W4220896684 hasConceptScore W4220896684C203014093 @default.
• W4220896684 hasConceptScore W4220896684C2776816829 @default.
• W4220896684 hasConceptScore W4220896684C2776914184 @default.
• W4220896684 hasConceptScore W4220896684C2777714996 @default.
• W4220896684 hasConceptScore W4220896684C2777961210 @default.
• W4220896684 hasConceptScore W4220896684C2778754761 @default.
• W4220896684 hasConceptScore W4220896684C2778938600 @default.
• W4220896684 hasConceptScore W4220896684C2781196776 @default.
• W4220896684 hasConceptScore W4220896684C71924100 @default.
• W4220896684 hasConceptScore W4220896684C98274493 @default.
• W4220896684 hasIssue "1" @default.
• W4220896684 hasLocation W42208966841 @default.
• W4220896684 hasLocation W42208966842 @default.
• W4220896684 hasLocation W42208966843 @default.
• W4220896684 hasLocation W42208966844 @default.
• W4220896684 hasOpenAccess W4220896684 @default.
• W4220896684 hasPrimaryLocation W42208966841 @default.
• W4220896684 hasRelatedWork W2004920288 @default.
• W4220896684 hasRelatedWork W2005544826 @default.
• W4220896684 hasRelatedWork W2075115648 @default.
• W4220896684 hasRelatedWork W2185106638 @default.

• next