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• W4220897250 abstract "Kawasaki disease (KD) is an acute febrile vasculitis. Patients with previous KD have increased risk of coronary arterial aneurysms (CAA) and early-onset arteriosclerosis. Endothelial dysfunction is the earliest manifestation of arteriosclerosis. We aimed to explore the endothelial function and clinical characteristics of patients with previous KD. In this case–control study, we investigated childhood KD patients, with and without CAA, and a group of healthy controls. We obtained the anthropometric measurements, metabolic markers, vascular ultrasonography evaluating arterial stiffness and flow-mediated dilatation (FMD), and clinical information obtained by reviewing the patients' charts. Continuous variables were compared using non-parametric analyses and categorical variables, using the chi-square or Fisher's exact tests. Seventy KD patients (median current age, 12.95 years; median follow-up duration, 10.88 years) and 14 healthy controls were recruited. FMD was significantly lower in the CAA group (n = 15) than the control group (FMDs: 5.59% [interquartile range, 3.99–6.86%] vs. 7.49% [5.96–9.42%], p = 0.049; diastolic FMD: 6.48% [4.14–7.32%] vs. 7.87% [6.19–9.98%], p = 0.042). The CAA group had a higher percentage of impaired FMD and the significantly largest coronary segments of the three groups. Other parameters including metabolic markers, carotid intima-media thickness, and arterial stiffness were not statistically different. KD patients, especially those with CAAs, may have impaired endothelial function. FMD may be a good indicator of endothelial dysfunction for use in long-term follow-up of KD patients." @default.
• W4220897250 created "2022-04-03" @default.
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• W4220897250 date "2023-04-01" @default.
• W4220897250 modified "2023-09-25" @default.
• W4220897250 title "Assessment of vascular and endothelial function in Kawasaki disease" @default.
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• W4220897250 doi "https://doi.org/10.1016/j.bj.2022.03.010" @default.
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