FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220901829> ?p ?o ?g. }

• W4220901829 abstract "Aging is associated with physiological and pathological changes and presents health complications, such as dementia. Isolation has also been associated with the experience of growing old. Both have been linked individually to the incidence of cognitive decline. In this present study, the effects of these two phenomena have been looked at in animal models where aging was induced with D(+)Galactose in mice who underwent long-term post-weaned social isolation (L-PWSI). Assessing cognitive function using Y-maze, Morris water maze (MWM), and passive avoidance tests (PATs) confirmed that cognition is impaired in either of the treatments but worsened when the D(+)Galactose mice were subjected to L-PWSI. Moreover, a synaptic protein, PSD95, and dendritic spines density were significantly reduced in the L-PWSI and D(+)Galactose-treated mice. Our previous study revealed that autophagy deficit is involved in cognitive impairment in the L-PWSI model. Here, we first report the inhibited cell cycle in L-PWSI, combined with the decreased autophagy, aggravates cognitive impairment in D(+)Galactose-treated mice. Beyond these, the autophagy and cell cycle mechanisms that link isolation and aging have been explored. The close association between isolation and aging in humans is very real and needs much research attention going forward for possible therapeutic interventions." @default.
• W4220901829 created "2022-04-03" @default.
• W4220901829 creator A5018863416 @default.
• W4220901829 creator A5020841128 @default.
• W4220901829 creator A5021719486 @default.
• W4220901829 creator A5033732336 @default.
• W4220901829 creator A5036768421 @default.
• W4220901829 creator A5081394455 @default.
• W4220901829 creator A5084587577 @default.
• W4220901829 date "2022-03-24" @default.
• W4220901829 modified "2023-10-16" @default.
• W4220901829 title "Long-Term Social Isolation-Induced Autophagy Inhibition and Cell Senescence Aggravate Cognitive Impairment in D(+)Galactose-Treated Male Mice" @default.
• W4220901829 cites W1588056972 @default.
• W4220901829 cites W1614009502 @default.
• W4220901829 cites W1619415434 @default.
• W4220901829 cites W1914412773 @default.
• W4220901829 cites W1970290986 @default.
• W4220901829 cites W1975396085 @default.
• W4220901829 cites W1981747529 @default.
• W4220901829 cites W1983936342 @default.
• W4220901829 cites W1994580609 @default.
• W4220901829 cites W1998040747 @default.
• W4220901829 cites W2011014580 @default.
• W4220901829 cites W2012588981 @default.
• W4220901829 cites W2013283005 @default.
• W4220901829 cites W2023831571 @default.
• W4220901829 cites W2024782183 @default.
• W4220901829 cites W2052245613 @default.
• W4220901829 cites W2055026367 @default.
• W4220901829 cites W2071732389 @default.
• W4220901829 cites W2113957290 @default.
• W4220901829 cites W2116114482 @default.
• W4220901829 cites W2118161501 @default.
• W4220901829 cites W2121371748 @default.
• W4220901829 cites W2122791600 @default.
• W4220901829 cites W2133377747 @default.
• W4220901829 cites W2171367003 @default.
• W4220901829 cites W2224270925 @default.
• W4220901829 cites W2239872130 @default.
• W4220901829 cites W2503694124 @default.
• W4220901829 cites W2772087535 @default.
• W4220901829 cites W2779251379 @default.
• W4220901829 cites W2784211834 @default.
• W4220901829 cites W2784426934 @default.
• W4220901829 cites W2795845448 @default.
• W4220901829 cites W2883090291 @default.
• W4220901829 cites W2884146924 @default.
• W4220901829 cites W2889922870 @default.
• W4220901829 cites W2890715706 @default.
• W4220901829 cites W2900575344 @default.
• W4220901829 cites W2912307432 @default.
• W4220901829 cites W2913103261 @default.
• W4220901829 cites W2974795043 @default.
• W4220901829 cites W2975247816 @default.
• W4220901829 cites W3018363259 @default.
• W4220901829 cites W3033818136 @default.
• W4220901829 cites W3043375718 @default.
• W4220901829 cites W3105929256 @default.
• W4220901829 cites W3111207111 @default.
• W4220901829 cites W3157843165 @default.
• W4220901829 cites W3217142324 @default.
• W4220901829 doi "https://doi.org/10.3389/fnagi.2022.777700" @default.
• W4220901829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35401146" @default.
• W4220901829 hasPublicationYear "2022" @default.
• W4220901829 type Work @default.
• W4220901829 citedByCount "1" @default.
• W4220901829 countsByYear W42209018292023 @default.
• W4220901829 crossrefType "journal-article" @default.
• W4220901829 hasAuthorship W4220901829A5018863416 @default.
• W4220901829 hasAuthorship W4220901829A5020841128 @default.
• W4220901829 hasAuthorship W4220901829A5021719486 @default.
• W4220901829 hasAuthorship W4220901829A5033732336 @default.
• W4220901829 hasAuthorship W4220901829A5036768421 @default.
• W4220901829 hasAuthorship W4220901829A5081394455 @default.
• W4220901829 hasAuthorship W4220901829A5084587577 @default.
• W4220901829 hasBestOaLocation W42209018291 @default.
• W4220901829 hasConcept C118552586 @default.
• W4220901829 hasConcept C12515866 @default.
• W4220901829 hasConcept C126322002 @default.
• W4220901829 hasConcept C15744967 @default.
• W4220901829 hasConcept C169760540 @default.
• W4220901829 hasConcept C169900460 @default.
• W4220901829 hasConcept C190283241 @default.
• W4220901829 hasConcept C203522944 @default.
• W4220901829 hasConcept C207886595 @default.
• W4220901829 hasConcept C2776893239 @default.
• W4220901829 hasConcept C2778173381 @default.
• W4220901829 hasConcept C2779134260 @default.
• W4220901829 hasConcept C2779483572 @default.
• W4220901829 hasConcept C2781161787 @default.
• W4220901829 hasConcept C2984863031 @default.
• W4220901829 hasConcept C2984915365 @default.
• W4220901829 hasConcept C44752575 @default.
• W4220901829 hasConcept C522857546 @default.
• W4220901829 hasConcept C55493867 @default.
• W4220901829 hasConcept C71924100 @default.
• W4220901829 hasConcept C74909509 @default.
• W4220901829 hasConcept C86803240 @default.
• W4220901829 hasConceptScore W4220901829C118552586 @default.
• W4220901829 hasConceptScore W4220901829C12515866 @default.

• next