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- W4220902011 abstract "The lymphoid system consists of primary and secondary lymphoid tissues. Primary tissues, including the bone marrow and thymus, are sites of lymphocyte production, development, and maturation. Secondary lymphoid tissues are the sites where lymphocytes interact with each other as well as antigen-presenting cells (APC) in the orchestration of the adaptive immune response. The lymph node is the primary site of the adaptive immune response to antigens, bringing together antigen, APC, and lymphocytes. Where lymph nodes, the spleen, and mucosa-associated lymphoid tissue comprise the secondary lymphoid centers with the anatomic localization of these organs similar between individuals of a species, tertiary lymphoid centers with similar structure to lymph nodes develop ectopically in response to chronic inflammation or neoplasia. Similar to lymph node development, tertiary centers are believed to be induced by chemokine secretion by stromal cells localized to the site of chronic inflammation." @default.
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- W4220902011 date "2022-03-04" @default.
- W4220902011 modified "2023-09-27" @default.
- W4220902011 title "Structure, Function, and Disorders of Lymphoid Tissue" @default.
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- W4220902011 doi "https://doi.org/10.1002/9781119500537.ch51" @default.
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