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• W4220903127 abstract "The previous chapters have outlined the cellular and clinical aspects of both the acquired and congenital long QT syndromes (LQTS) that predispose to torsades de pointes (TdP). The genomic medicine era is a promising time for the development of improved diagnostics and therapeutics in this field. However, many questions related to the basic mechanisms, population incidence and clinical management of TdP remain unanswered despite decades of study. Even basic issues, like the best electrocardiogram (ECG) screening practices, the most appropriate QT interval correction formula to use, and the ethnicity and sex-based differences that exist remain unclear. Additionally, there is a lack of controlled studies on TdP in the literature. In part, this is driven by a poor ability, without prolonged monitoring, to detect TdP events, which may be fatal in the community or too transient in nature to diagnose. Wearable ECG technologies and clinical decision support systems will likely help to bridge some of the gaps that exist in drug safety monitoring and defining TdP prevalence. Finally, novel genomic and precision guided therapies require further evaluation. Ribonucleic acid (RNA) interference therapies and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-9 genome editing are exciting new avenues to pursue. However, these technologies have not been evaluated in humans with LQTS or TdP. Their anticipated cost coupled with the complicated genetic architecture of the QT interval may impose practical barriers to utilization in some circumstances. In this final chapter, these and several other unanswered questions in LQTS and TdP will be addressed, and four key domains are presented that may guide future studies." @default.
• W4220903127 created "2022-04-03" @default.
• W4220903127 creator A5005764816 @default.
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• W4220903127 creator A5083075230 @default.
• W4220903127 date "2022-01-01" @default.
• W4220903127 modified "2023-10-18" @default.
• W4220903127 title "Important unanswered research questions related to torsades de pointes" @default.
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