Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220903374> ?p ?o ?g. }
- W4220903374 endingPage "494" @default.
- W4220903374 startingPage "494" @default.
- W4220903374 abstract "To achieve hepatitis C elimination, treatment programs need to engage, treat, and cure people who inject drugs.To compare a low-threshold, nonstigmatizing hepatitis C treatment program that was colocated at a syringe service program (accessible care) with facilitated referral to local clinicians through a patient navigation program (usual care).This single-site randomized clinical trial was conducted at the Lower East Side Harm Reduction Center, a syringe service program in New York, New York, and included 167 participants who were hepatitis C virus RNA-positive and had injected drugs during the prior 90 days. Participants enrolled between July 2017 and March 2020. Data were analyzed after all patients completed 1 year of follow-up (after March 2021).Participants were randomized 1:1 to the accessible care or usual care arm.The primary end point was achieving sustained virologic response within 12 months of enrollment.Among the 572 participants screened, 167 (mean [SD] age, 42.0 [10.6] years; 128 (77.6%) male, 36 (21.8%) female, and 1 (0.6) transgender individuals; 8 (4.8%) Black, 97 (58.5%) Hispanic, and 53 (32.1%) White individuals) met eligibility criteria and were enrolled, with 2 excluded postrandomization (n = 165). Baseline characteristics were similar between the 2 arms. In the intention-to-treat analysis, 55 of 82 participants (67.1%) in the accessible care arm and 19 of 83 participants (22.9%) in the usual care arm achieved a sustained virologic response (P < .001). Loss to follow-up (12.2% [accessible care] and 16.9% [usual care]; P = .51) was similar in the 2 arms. Of the participants who received therapy, 55 of 64 (85.9%) and 19 of 22 (86.3%) achieved a sustained virologic response in the accessible care and usual care arms, respectively (P = .96). Significantly more participants in the accessible care arm achieved all steps in the care cascade, with the greatest attrition in the usual care arm seen in referral to hepatitis C virus clinician and attending clinical visit.In this randomized clinical trial, among people who inject drugs with hepatitis C infection, significantly higher rates of cure were achieved using the accessible care model that focused on low-threshold, colocated, destigmatized, and flexible hepatitis C care compared with facilitated referral. To achieve hepatitis C elimination, expansion of treatment programs that are specifically geared toward engaging people who inject drugs is paramount.ClinicalTrials.gov Identifier: NCT03214679." @default.
- W4220903374 created "2022-04-03" @default.
- W4220903374 creator A5027045614 @default.
- W4220903374 creator A5032577924 @default.
- W4220903374 creator A5033864169 @default.
- W4220903374 creator A5059731962 @default.
- W4220903374 creator A5061514359 @default.
- W4220903374 creator A5067317038 @default.
- W4220903374 creator A5081473731 @default.
- W4220903374 creator A5087344011 @default.
- W4220903374 date "2022-05-01" @default.
- W4220903374 modified "2023-10-10" @default.
- W4220903374 title "Accessible Hepatitis C Care for People Who Inject Drugs" @default.
- W4220903374 cites W1903580466 @default.
- W4220903374 cites W2044421611 @default.
- W4220903374 cites W2066074857 @default.
- W4220903374 cites W2070688872 @default.
- W4220903374 cites W2108732637 @default.
- W4220903374 cites W2171452733 @default.
- W4220903374 cites W2288320856 @default.
- W4220903374 cites W2326739955 @default.
- W4220903374 cites W2345197548 @default.
- W4220903374 cites W2462340700 @default.
- W4220903374 cites W2560448494 @default.
- W4220903374 cites W2765348434 @default.
- W4220903374 cites W2778170606 @default.
- W4220903374 cites W2790029153 @default.
- W4220903374 cites W2889967332 @default.
- W4220903374 cites W2903249677 @default.
- W4220903374 cites W2906035093 @default.
- W4220903374 cites W2917355127 @default.
- W4220903374 cites W2921016611 @default.
- W4220903374 cites W2939434034 @default.
- W4220903374 cites W2940255242 @default.
- W4220903374 cites W2955355575 @default.
- W4220903374 cites W2977550079 @default.
- W4220903374 cites W2990999638 @default.
- W4220903374 cites W3010430917 @default.
- W4220903374 cites W3015631374 @default.
- W4220903374 cites W3040491136 @default.
- W4220903374 cites W3105267118 @default.
- W4220903374 cites W3132509466 @default.
- W4220903374 cites W4243139075 @default.
- W4220903374 cites W4245776575 @default.
- W4220903374 cites W4256166030 @default.
- W4220903374 doi "https://doi.org/10.1001/jamainternmed.2022.0170" @default.
- W4220903374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35285851" @default.
- W4220903374 hasPublicationYear "2022" @default.
- W4220903374 type Work @default.
- W4220903374 citedByCount "19" @default.
- W4220903374 countsByYear W42209033742022 @default.
- W4220903374 countsByYear W42209033742023 @default.
- W4220903374 crossrefType "journal-article" @default.
- W4220903374 hasAuthorship W4220903374A5027045614 @default.
- W4220903374 hasAuthorship W4220903374A5032577924 @default.
- W4220903374 hasAuthorship W4220903374A5033864169 @default.
- W4220903374 hasAuthorship W4220903374A5059731962 @default.
- W4220903374 hasAuthorship W4220903374A5061514359 @default.
- W4220903374 hasAuthorship W4220903374A5067317038 @default.
- W4220903374 hasAuthorship W4220903374A5081473731 @default.
- W4220903374 hasAuthorship W4220903374A5087344011 @default.
- W4220903374 hasBestOaLocation W42209033742 @default.
- W4220903374 hasConcept C126322002 @default.
- W4220903374 hasConcept C160735492 @default.
- W4220903374 hasConcept C162324750 @default.
- W4220903374 hasConcept C168563851 @default.
- W4220903374 hasConcept C2776135927 @default.
- W4220903374 hasConcept C2776455275 @default.
- W4220903374 hasConcept C3013748606 @default.
- W4220903374 hasConcept C50522688 @default.
- W4220903374 hasConcept C512399662 @default.
- W4220903374 hasConcept C529928208 @default.
- W4220903374 hasConcept C71924100 @default.
- W4220903374 hasConceptScore W4220903374C126322002 @default.
- W4220903374 hasConceptScore W4220903374C160735492 @default.
- W4220903374 hasConceptScore W4220903374C162324750 @default.
- W4220903374 hasConceptScore W4220903374C168563851 @default.
- W4220903374 hasConceptScore W4220903374C2776135927 @default.
- W4220903374 hasConceptScore W4220903374C2776455275 @default.
- W4220903374 hasConceptScore W4220903374C3013748606 @default.
- W4220903374 hasConceptScore W4220903374C50522688 @default.
- W4220903374 hasConceptScore W4220903374C512399662 @default.
- W4220903374 hasConceptScore W4220903374C529928208 @default.
- W4220903374 hasConceptScore W4220903374C71924100 @default.
- W4220903374 hasIssue "5" @default.
- W4220903374 hasLocation W42209033741 @default.
- W4220903374 hasLocation W42209033742 @default.
- W4220903374 hasLocation W42209033743 @default.
- W4220903374 hasOpenAccess W4220903374 @default.
- W4220903374 hasPrimaryLocation W42209033741 @default.
- W4220903374 hasRelatedWork W1527820603 @default.
- W4220903374 hasRelatedWork W1966261153 @default.
- W4220903374 hasRelatedWork W2355769538 @default.
- W4220903374 hasRelatedWork W2371771839 @default.
- W4220903374 hasRelatedWork W2590224211 @default.
- W4220903374 hasRelatedWork W2762821049 @default.
- W4220903374 hasRelatedWork W3148047305 @default.
- W4220903374 hasRelatedWork W3166686771 @default.