FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220904301> ?p ?o ?g. }

• W4220904301 endingPage "1086" @default.
• W4220904301 startingPage "1069" @default.
• W4220904301 abstract "This study aims to illustrate the potential of sequential experimentation for statistically scientific based optimization of Tazarotene (TAZA) cubosomes.Hot melt emulsification method was used for cubosomes preparation. A preliminary (3.2) mixed factorial design (MFD) was conducted to choose suitable types of stabilizer and surfactant that maximize entrapment efficiency (EE) and minimize particle size (PS). These chosen stabilizer and surfactant were to be used in the statistical design proposed for optimization of TAZA cubosomes (I-optimal mixture design) (IOMD). Glyceryl monooleate (GMO), stabilizer and surfactant amounts were the three mixture components (MixCs) studied in that design. Responses (EE, PS and drug percent released after 24 hours (Q24h)) were statistically analyzed. Numerical optimization using desirability function based on different responses' importance was used to find an IOMD-optimized formulation (IOMD-OF) with the predetermined characters. Then, a novel statistical methodology of design space expansion was adopted to enhance Q24h. Suitable models to express EE, PS and Q24h were elucidated over the expanded mixture design (EMD) space. Validity of derived models was verified via prediction intervals and percent deviations of actual values from predicted ones for all the EMD design points. EMD was then navigated to find EMD-OF.Analysis of MFD showed that Pluronic-F68 and polyvinyl alcohol were the best stabilizer and surfactant to be used. First stage optimization after IOMD analysis led to a formulation with unsatisfactory Q24h of 58.8%. After design space expansion adoption, re-analysis and re-optimization, a satisfactory EMD-OF having EE of 82.1%, PS of 273.0 nm and Q24h of 68.8% was found.Statistical sequential experimentation with the novel design space expansion approach proved to be a successful paradigm for enhancing TAZA cubosomes optimization. Thus, this paradigm is expected to have promising future applications in various pharmaceutical formulations optimization." @default.
• W4220904301 created "2022-04-03" @default.
• W4220904301 creator A5033251445 @default.
• W4220904301 creator A5035776595 @default.
• W4220904301 creator A5084216498 @default.
• W4220904301 date "2022-03-01" @default.
• W4220904301 modified "2023-10-14" @default.
• W4220904301 title "Statistical Sequential Experimentation: Preliminary Mixed Factorial Design, I-Optimal Mixture Design Then Finally Novel Design Space Expansion for Optimization of Tazarotene Cubosomes" @default.
• W4220904301 cites W1481509073 @default.
• W4220904301 cites W1651000550 @default.
• W4220904301 cites W1965692568 @default.
• W4220904301 cites W1968098666 @default.
• W4220904301 cites W2013500776 @default.
• W4220904301 cites W2026428270 @default.
• W4220904301 cites W2031095463 @default.
• W4220904301 cites W2034663238 @default.
• W4220904301 cites W2041277866 @default.
• W4220904301 cites W2043050452 @default.
• W4220904301 cites W2047405247 @default.
• W4220904301 cites W2058945924 @default.
• W4220904301 cites W2065870072 @default.
• W4220904301 cites W2069977684 @default.
• W4220904301 cites W2077252426 @default.
• W4220904301 cites W2083172358 @default.
• W4220904301 cites W2083533532 @default.
• W4220904301 cites W2086725441 @default.
• W4220904301 cites W2088998579 @default.
• W4220904301 cites W2101300214 @default.
• W4220904301 cites W2156525780 @default.
• W4220904301 cites W2157430128 @default.
• W4220904301 cites W2170503291 @default.
• W4220904301 cites W2210405447 @default.
• W4220904301 cites W2236407834 @default.
• W4220904301 cites W2259225385 @default.
• W4220904301 cites W2260161590 @default.
• W4220904301 cites W2328633968 @default.
• W4220904301 cites W2345032351 @default.
• W4220904301 cites W2468932732 @default.
• W4220904301 cites W2525278375 @default.
• W4220904301 cites W2561224471 @default.
• W4220904301 cites W2584132789 @default.
• W4220904301 cites W2589299028 @default.
• W4220904301 cites W2613675449 @default.
• W4220904301 cites W2772393177 @default.
• W4220904301 cites W2794135364 @default.
• W4220904301 cites W2795953388 @default.
• W4220904301 cites W2799323837 @default.
• W4220904301 cites W2801786723 @default.
• W4220904301 cites W2804846127 @default.
• W4220904301 cites W2805756697 @default.
• W4220904301 cites W2805779846 @default.
• W4220904301 cites W2807203217 @default.
• W4220904301 cites W2808959307 @default.
• W4220904301 cites W281489398 @default.
• W4220904301 cites W2898133507 @default.
• W4220904301 cites W2913826149 @default.
• W4220904301 cites W2938677819 @default.
• W4220904301 cites W2940058582 @default.
• W4220904301 cites W2958759663 @default.
• W4220904301 cites W2963420418 @default.
• W4220904301 cites W3000008391 @default.
• W4220904301 cites W3020995052 @default.
• W4220904301 cites W3021437804 @default.
• W4220904301 cites W3021561583 @default.
• W4220904301 cites W3037898199 @default.
• W4220904301 cites W3047177224 @default.
• W4220904301 cites W3092028438 @default.
• W4220904301 cites W3093098028 @default.
• W4220904301 cites W3127861128 @default.
• W4220904301 cites W3176385631 @default.
• W4220904301 cites W3208531235 @default.
• W4220904301 cites W419513368 @default.
• W4220904301 doi "https://doi.org/10.2147/ijn.s337130" @default.
• W4220904301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35309964" @default.
• W4220904301 hasPublicationYear "2022" @default.
• W4220904301 type Work @default.
• W4220904301 citedByCount "3" @default.
• W4220904301 countsByYear W42209043012022 @default.
• W4220904301 countsByYear W42209043012023 @default.
• W4220904301 crossrefType "journal-article" @default.
• W4220904301 hasAuthorship W4220904301A5033251445 @default.
• W4220904301 hasAuthorship W4220904301A5035776595 @default.
• W4220904301 hasAuthorship W4220904301A5084216498 @default.
• W4220904301 hasBestOaLocation W42209043011 @default.
• W4220904301 hasConcept C105795698 @default.
• W4220904301 hasConcept C127413603 @default.
• W4220904301 hasConcept C16469947 @default.
• W4220904301 hasConcept C169222746 @default.
• W4220904301 hasConcept C186394612 @default.
• W4220904301 hasConcept C192562407 @default.
• W4220904301 hasConcept C2777502316 @default.
• W4220904301 hasConcept C33923547 @default.
• W4220904301 hasConcept C34559072 @default.
• W4220904301 hasConcept C41008148 @default.
• W4220904301 hasConcept C42360764 @default.
• W4220904301 hasConcept C58226133 @default.
• W4220904301 hasConcept C78519656 @default.
• W4220904301 hasConceptScore W4220904301C105795698 @default.

• next