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- W4220906475 abstract "Breast cancer has remained the most common malignancy in women over the past two decades. As lifestyle and living environments have changed, alterations to the disease spectrum have inevitably occurred in this time. As molecular profiling has become a routine diagnostic and objective indicator of breast cancer etiology, we analyzed changes in gene expression in breast cancer populations over two decades using The Cancer Genome Atlas database.We performed Heatmap and Venn diagram analyses to identify constantly up- and down-regulated genes in breast cancer patients of this cohort. We used Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses to visualize associated functional pathways.We determined that three oncogenes, PD-L2, ETV5, and MTOR and 113 long intergenic non-coding RNAs (lincRNAs) were constantly up-regulated, whereas two oncogenes, BCR and GTF2I, one tumor suppression gene MEN1, and 30 lincRNAs were constantly down-regulated. Up-regulated genes were enriched in focal adhesion and PI3K-Akt signaling pathways, etc., and down-regulated genes were significantly enriched in metabolic pathways and viral myocarditis. Eight up-regulated genes exhibited doubled or higher expression and the expression of three down-regulated genes was halved or lowered and correlated with long-term survival.In this study, we found that gene expression and molecular pathway enrichments are constantly changing with time, importantly, some altered genes were associated with prognostics and are potential therapeutic targets, suggesting that the current molecular subtyping system must be updated to keep pace with this dynamic change." @default.
- W4220906475 created "2022-04-03" @default.
- W4220906475 creator A5010065143 @default.
- W4220906475 creator A5018764399 @default.
- W4220906475 creator A5061589192 @default.
- W4220906475 creator A5076440833 @default.
- W4220906475 date "2022-03-22" @default.
- W4220906475 modified "2023-10-14" @default.
- W4220906475 title "Gene expression trend changes in breast cancer populations over two decades: insights from The Cancer Genome Atlas database" @default.
- W4220906475 cites W1484764033 @default.
- W4220906475 cites W1488814076 @default.
- W4220906475 cites W1562190372 @default.
- W4220906475 cites W1573186537 @default.
- W4220906475 cites W1585124497 @default.
- W4220906475 cites W1975903971 @default.
- W4220906475 cites W1982139221 @default.
- W4220906475 cites W1987326983 @default.
- W4220906475 cites W1996778928 @default.
- W4220906475 cites W2000269004 @default.
- W4220906475 cites W2001215449 @default.
- W4220906475 cites W2007245209 @default.
- W4220906475 cites W2024927014 @default.
- W4220906475 cites W2036180531 @default.
- W4220906475 cites W2042298854 @default.
- W4220906475 cites W2044702943 @default.
- W4220906475 cites W2048568101 @default.
- W4220906475 cites W2049621625 @default.
- W4220906475 cites W2055475863 @default.
- W4220906475 cites W2056928766 @default.
- W4220906475 cites W2061922176 @default.
- W4220906475 cites W2062216607 @default.
- W4220906475 cites W2064052354 @default.
- W4220906475 cites W2072816950 @default.
- W4220906475 cites W2077666591 @default.
- W4220906475 cites W2080633639 @default.
- W4220906475 cites W2100476600 @default.
- W4220906475 cites W2105085055 @default.
- W4220906475 cites W2110361622 @default.
- W4220906475 cites W2112738257 @default.
- W4220906475 cites W2113458582 @default.
- W4220906475 cites W2117436948 @default.
- W4220906475 cites W2118666817 @default.
- W4220906475 cites W2124721975 @default.
- W4220906475 cites W2129420347 @default.
- W4220906475 cites W2132619562 @default.
- W4220906475 cites W2133264822 @default.
- W4220906475 cites W2140628034 @default.
- W4220906475 cites W2143083710 @default.
- W4220906475 cites W2148194373 @default.
- W4220906475 cites W2158485828 @default.
- W4220906475 cites W2160450758 @default.
- W4220906475 cites W2161977537 @default.
- W4220906475 cites W2164071805 @default.
- W4220906475 cites W2165038925 @default.
- W4220906475 cites W2165818300 @default.
- W4220906475 cites W2166609686 @default.
- W4220906475 cites W2290950904 @default.
- W4220906475 cites W2418622096 @default.
- W4220906475 cites W2517421365 @default.
- W4220906475 cites W2559588208 @default.
- W4220906475 cites W2560406314 @default.
- W4220906475 cites W2560409587 @default.
- W4220906475 cites W2615791483 @default.
- W4220906475 cites W2618058692 @default.
- W4220906475 cites W2619858681 @default.
- W4220906475 cites W2621271973 @default.
- W4220906475 cites W2727347885 @default.
- W4220906475 cites W2735687500 @default.
- W4220906475 cites W2886477543 @default.
- W4220906475 cites W2890702198 @default.
- W4220906475 cites W2899028887 @default.
- W4220906475 cites W2902218997 @default.
- W4220906475 cites W2902946687 @default.
- W4220906475 cites W2921082412 @default.
- W4220906475 cites W2939774129 @default.
- W4220906475 cites W2949280410 @default.
- W4220906475 cites W2955641531 @default.
- W4220906475 cites W2972653526 @default.
- W4220906475 cites W2975869948 @default.
- W4220906475 cites W2977387944 @default.
- W4220906475 cites W2979291688 @default.
- W4220906475 cites W2990398119 @default.
- W4220906475 cites W2997316320 @default.
- W4220906475 cites W3003940860 @default.
- W4220906475 cites W3012586848 @default.
- W4220906475 cites W3021125337 @default.
- W4220906475 cites W3036019667 @default.
- W4220906475 cites W3095855342 @default.
- W4220906475 cites W3109510743 @default.
- W4220906475 cites W3122125777 @default.
- W4220906475 cites W3128646645 @default.
- W4220906475 cites W3146674090 @default.
- W4220906475 cites W3152698713 @default.
- W4220906475 cites W3171898652 @default.
- W4220906475 cites W4205724345 @default.
- W4220906475 cites W4211005384 @default.
- W4220906475 cites W4232899433 @default.
- W4220906475 doi "https://doi.org/10.1186/s41065-022-00230-3" @default.
- W4220906475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35317849" @default.
- W4220906475 hasPublicationYear "2022" @default.