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• W4220909968 abstract "Approximately 50% of patients with metastatic HER2-positive (HER2+) breast cancer develop brain metastases (BCBMs). We report that the tumor suppressor p16INK4A is deficient in the majority of HER2+ BCBMs. p16INK4A-deficiency as measured by protein immunohistochemistry predicted response to combined tucatinib and abemaciclib in orthotopic patient-derived xenografts (PDXs) of HER2 + BCBMs. Our findings establish the rationale for a biomarker-driven clinical trial of combined CDK4/6- and HER2-targeted agents for patients with HER2 + BCBM." @default.
• W4220909968 created "2022-04-03" @default.
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• W4220909968 date "2022-03-18" @default.
• W4220909968 modified "2023-10-14" @default.
• W4220909968 title "p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases" @default.
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• W4220909968 doi "https://doi.org/10.1038/s41467-022-29081-2" @default.
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