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- W4220914462 abstract "Abstract In order to search for high activity acetylcholinesterase (AChE) inhibitors, novel 2 H ‐thiazole[3,2‐ b ][1,2,4]triazine‐3,7‐diones were synthesized by substituted benzaldehyde, bromoacetonitrile and 6‐benzyl‐3‐thio‐3,4‐dihydro‐1,2,4‐triazine‐5(2 H )‐one in one pot under the assistance of ultrasound. The synthesis possible reaction mechanism were proposed. The structures of the target compounds were confirmed by 1 H NMR, 13 C NMR and HRMS. All the target compounds had inhibitory activity against AChE, and the compound 6‐benzyl‐2‐(4‐methoxybenzylidene)‐2 H ‐thiazolo[3,2‐ b ]‐1,2,4‐triazine‐3,7‐dione had the best activity (0.37±0.02 μM) according to the activity experimental results. The binding mode of the compound and AChE was studied by molecular docking. 2 H ‐thiazole[3,2‐ b ][1,2,4]triazine‐3,7‐diones could provide reference for the development of new AChE inhibitors with independent intellectual property rights." @default.
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- W4220914462 date "2022-03-09" @default.
- W4220914462 modified "2023-10-14" @default.
- W4220914462 title "Design, Synthesis and Biological Evaluation of Novel 6‐Benzyl‐2‐benzylidene‐2<i>H</i>‐thiazolo[3,2‐<i>b</i>][1,2,4]triazine‐3,7‐diones as Acetylcholinesterase Inhibitors" @default.
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- W4220914462 doi "https://doi.org/10.1002/slct.202103981" @default.
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