FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220919070> ?p ?o ?g. }

• W4220919070 endingPage "910" @default.
• W4220919070 startingPage "894" @default.
• W4220919070 abstract "The spinal cord emerges from a niche of neuromesodermal progenitors (NMPs) formed and maintained by WNT/fibroblast growth factor (FGF) signals at the posterior end of the embryo. NMPs can be generated from human pluripotent stem cells and hold promise for spinal cord replacement therapies. However, NMPs are transient, which compromises production of the full range of rostrocaudal spinal cord identities in vitro. Here we report the generation of NMP-derived pre-neural progenitors (PNPs) with stem cell-like self-renewal capacity. PNPs maintain pre-spinal cord identity for 7–10 passages, dividing to self-renew and to make neural crest progenitors, while gradually adopting a more posterior identity by activating colinear HOX gene expression. The HOX clock can be halted through GDF11-mediated signal inhibition to produce a PNP and NC population with a thoracic identity that can be maintained for up to 30 passages." @default.
• W4220919070 created "2022-04-03" @default.
• W4220919070 creator A5005149415 @default.
• W4220919070 creator A5018555993 @default.
• W4220919070 creator A5041877598 @default.
• W4220919070 creator A5044204439 @default.
• W4220919070 creator A5044946533 @default.
• W4220919070 creator A5058101804 @default.
• W4220919070 creator A5069612478 @default.
• W4220919070 creator A5089507709 @default.
• W4220919070 date "2022-04-01" @default.
• W4220919070 modified "2023-10-14" @default.
• W4220919070 title "Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro" @default.
• W4220919070 cites W1461755553 @default.
• W4220919070 cites W1527331090 @default.
• W4220919070 cites W1931118778 @default.
• W4220919070 cites W1968819846 @default.
• W4220919070 cites W1975805528 @default.
• W4220919070 cites W1977735902 @default.
• W4220919070 cites W1985222746 @default.
• W4220919070 cites W1985888836 @default.
• W4220919070 cites W1996989066 @default.
• W4220919070 cites W2014582387 @default.
• W4220919070 cites W2022824806 @default.
• W4220919070 cites W2040365962 @default.
• W4220919070 cites W2043807089 @default.
• W4220919070 cites W2045219848 @default.
• W4220919070 cites W2064794918 @default.
• W4220919070 cites W2078832902 @default.
• W4220919070 cites W2079244396 @default.
• W4220919070 cites W2081214028 @default.
• W4220919070 cites W2081235375 @default.
• W4220919070 cites W2087367170 @default.
• W4220919070 cites W2095229526 @default.
• W4220919070 cites W2096448447 @default.
• W4220919070 cites W2103584976 @default.
• W4220919070 cites W2103661362 @default.
• W4220919070 cites W2107289504 @default.
• W4220919070 cites W2117265023 @default.
• W4220919070 cites W2119816938 @default.
• W4220919070 cites W2122968962 @default.
• W4220919070 cites W2135447402 @default.
• W4220919070 cites W2144156758 @default.
• W4220919070 cites W2150667223 @default.
• W4220919070 cites W2156684099 @default.
• W4220919070 cites W2166256370 @default.
• W4220919070 cites W2167524294 @default.
• W4220919070 cites W2171109270 @default.
• W4220919070 cites W2171674474 @default.
• W4220919070 cites W2289750443 @default.
• W4220919070 cites W2291751883 @default.
• W4220919070 cites W2478586778 @default.
• W4220919070 cites W2496249921 @default.
• W4220919070 cites W2563528111 @default.
• W4220919070 cites W2566241189 @default.
• W4220919070 cites W2607832145 @default.
• W4220919070 cites W2747297590 @default.
• W4220919070 cites W2753769089 @default.
• W4220919070 cites W2755736417 @default.
• W4220919070 cites W2792876614 @default.
• W4220919070 cites W2808627733 @default.
• W4220919070 cites W2885928265 @default.
• W4220919070 cites W2886748056 @default.
• W4220919070 cites W2910128325 @default.
• W4220919070 cites W2920133501 @default.
• W4220919070 cites W2922181325 @default.
• W4220919070 cites W2945853220 @default.
• W4220919070 cites W2968515123 @default.
• W4220919070 cites W3131411134 @default.
• W4220919070 cites W3134465191 @default.
• W4220919070 cites W3152240137 @default.
• W4220919070 doi "https://doi.org/10.1016/j.stemcr.2022.02.018" @default.
• W4220919070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35334218" @default.
• W4220919070 hasPublicationYear "2022" @default.
• W4220919070 type Work @default.
• W4220919070 citedByCount "11" @default.
• W4220919070 countsByYear W42209190702021 @default.
• W4220919070 countsByYear W42209190702022 @default.
• W4220919070 countsByYear W42209190702023 @default.
• W4220919070 crossrefType "journal-article" @default.
• W4220919070 hasAuthorship W4220919070A5005149415 @default.
• W4220919070 hasAuthorship W4220919070A5018555993 @default.
• W4220919070 hasAuthorship W4220919070A5041877598 @default.
• W4220919070 hasAuthorship W4220919070A5044204439 @default.
• W4220919070 hasAuthorship W4220919070A5044946533 @default.
• W4220919070 hasAuthorship W4220919070A5058101804 @default.
• W4220919070 hasAuthorship W4220919070A5069612478 @default.
• W4220919070 hasAuthorship W4220919070A5089507709 @default.
• W4220919070 hasBestOaLocation W42209190701 @default.
• W4220919070 hasConcept C104317684 @default.
• W4220919070 hasConcept C105702510 @default.
• W4220919070 hasConcept C107459253 @default.
• W4220919070 hasConcept C111039654 @default.
• W4220919070 hasConcept C126749454 @default.
• W4220919070 hasConcept C136834591 @default.
• W4220919070 hasConcept C137620995 @default.
• W4220919070 hasConcept C145103041 @default.
• W4220919070 hasConcept C150194340 @default.

• next