Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220924539> ?p ?o ?g. }
- W4220924539 endingPage "236" @default.
- W4220924539 startingPage "226" @default.
- W4220924539 abstract "Cariprazine is a piperazine derivative approved by the USFDA in 2015 as a novel atypical antipsychotic drug (APD) to treat adults with schizophrenia and bipolar manic or mixed episodes in adults. However, due to the partial agonist action on dopamine D2, D3 receptors, and serotonin 5-HT1A receptors as well as the antagonist effect on 5-HT2A, 5-HT2B, and H1 receptors, cariprazine differs pharmacologically from other APDs, both typical and atypical. Moreover, cariprazine also has a unique pharmacokinetic profile due to the formation of two clinically significant metabolites: desmethyl-cariprazine (DCAR) and desmethyl-cariprazine (DDCAR). They are eliminated by CYP3A4 and also, to a lesser extent, by CYP2D6. Here, we also review the effectiveness, safety, as well as current clinical update of cariprazine in bipolar I disorder associated with/without mania and schizophrenia through randomized and post-hoc analysis. The potential benefits of cariprazine as a promising therapeutic alternative in addressing major clinical requirements for better therapy of such severe neuropsychiatric conditions were demonstrated in this summarized review study." @default.
- W4220924539 created "2022-04-03" @default.
- W4220924539 creator A5001799331 @default.
- W4220924539 creator A5032317031 @default.
- W4220924539 creator A5062327802 @default.
- W4220924539 creator A5072676279 @default.
- W4220924539 creator A5074015295 @default.
- W4220924539 date "2023-02-01" @default.
- W4220924539 modified "2023-10-16" @default.
- W4220924539 title "Mini Review on Cariprazine: A Promising Antipsychotic Agent" @default.
- W4220924539 cites W119903107 @default.
- W4220924539 cites W1597234364 @default.
- W4220924539 cites W1862497742 @default.
- W4220924539 cites W1933744399 @default.
- W4220924539 cites W1974599939 @default.
- W4220924539 cites W1975124300 @default.
- W4220924539 cites W2001056528 @default.
- W4220924539 cites W2005660814 @default.
- W4220924539 cites W2006478810 @default.
- W4220924539 cites W2020995975 @default.
- W4220924539 cites W2021096501 @default.
- W4220924539 cites W2024410002 @default.
- W4220924539 cites W2037081441 @default.
- W4220924539 cites W2051869406 @default.
- W4220924539 cites W2068363909 @default.
- W4220924539 cites W2072245045 @default.
- W4220924539 cites W2076295979 @default.
- W4220924539 cites W2087688448 @default.
- W4220924539 cites W2089500825 @default.
- W4220924539 cites W2102541501 @default.
- W4220924539 cites W2105006312 @default.
- W4220924539 cites W2117968101 @default.
- W4220924539 cites W2124201657 @default.
- W4220924539 cites W2133171295 @default.
- W4220924539 cites W2135166041 @default.
- W4220924539 cites W2135689380 @default.
- W4220924539 cites W2140606211 @default.
- W4220924539 cites W2156743340 @default.
- W4220924539 cites W2160098367 @default.
- W4220924539 cites W2166977877 @default.
- W4220924539 cites W2167223183 @default.
- W4220924539 cites W2167715051 @default.
- W4220924539 cites W2202381266 @default.
- W4220924539 cites W2249246431 @default.
- W4220924539 cites W2262339371 @default.
- W4220924539 cites W2295131028 @default.
- W4220924539 cites W2320155748 @default.
- W4220924539 cites W2381683589 @default.
- W4220924539 cites W2481131359 @default.
- W4220924539 cites W2482680139 @default.
- W4220924539 cites W2514999534 @default.
- W4220924539 cites W2548043108 @default.
- W4220924539 cites W2605819674 @default.
- W4220924539 cites W2611979084 @default.
- W4220924539 cites W2619718464 @default.
- W4220924539 cites W2724473643 @default.
- W4220924539 cites W2745466963 @default.
- W4220924539 cites W2745836136 @default.
- W4220924539 cites W2763707279 @default.
- W4220924539 cites W2767793215 @default.
- W4220924539 cites W2770901977 @default.
- W4220924539 cites W2889066096 @default.
- W4220924539 cites W2889080334 @default.
- W4220924539 cites W2895340837 @default.
- W4220924539 cites W2921930118 @default.
- W4220924539 cites W2941689848 @default.
- W4220924539 cites W2954807799 @default.
- W4220924539 cites W2955832992 @default.
- W4220924539 cites W2978642460 @default.
- W4220924539 cites W2980904631 @default.
- W4220924539 cites W2982507974 @default.
- W4220924539 cites W3005676462 @default.
- W4220924539 cites W3097882403 @default.
- W4220924539 cites W3126067753 @default.
- W4220924539 cites W3171659459 @default.
- W4220924539 doi "https://doi.org/10.2174/1871527321666220324121935" @default.
- W4220924539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35331126" @default.
- W4220924539 hasPublicationYear "2023" @default.
- W4220924539 type Work @default.
- W4220924539 citedByCount "1" @default.
- W4220924539 countsByYear W42209245392023 @default.
- W4220924539 crossrefType "journal-article" @default.
- W4220924539 hasAuthorship W4220924539A5001799331 @default.
- W4220924539 hasAuthorship W4220924539A5032317031 @default.
- W4220924539 hasAuthorship W4220924539A5062327802 @default.
- W4220924539 hasAuthorship W4220924539A5072676279 @default.
- W4220924539 hasAuthorship W4220924539A5074015295 @default.
- W4220924539 hasConcept C118552586 @default.
- W4220924539 hasConcept C126322002 @default.
- W4220924539 hasConcept C15744967 @default.
- W4220924539 hasConcept C170493617 @default.
- W4220924539 hasConcept C2776412080 @default.
- W4220924539 hasConcept C2776701107 @default.
- W4220924539 hasConcept C2778938600 @default.
- W4220924539 hasConcept C2780494398 @default.
- W4220924539 hasConcept C58732023 @default.
- W4220924539 hasConcept C71924100 @default.
- W4220924539 hasConcept C98274493 @default.