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• W4220925195 startingPage "2407" @default.
• W4220925195 abstract "The high concentration of nucleic acids and positively charged proteins in the cell nucleus provides many possibilities for complex coacervation. We consider a prototypical mixture of nucleic acids together with the polycationic C-terminus of histone H1 (CH1). Using a minimal coarse-grained model that captures the shape, flexibility, and charge distributions of the molecules, we find that coacervates are readily formed at physiological ionic strengths, in agreement with experiment, with a progressive increase in local ordering at low ionic strength. Variation of the positions of charged residues in the protein tunes phase separation: for well-mixed or only moderately blocky distributions of charge, there is a modest increase of local ordering with increasing blockiness that is also associated with an increased propensity to phase separate. This ordering is also associated with a slowdown of rotational and translational diffusion in the dense phase. However, for more extreme blockiness (and consequently higher local charge density), we see a qualitative change in the condensed phase to become a segregated structure with a dramatically increased ordering of the DNA. Naturally occurring proteins with these sequence properties, such as protamines in sperm cells, are found to be associated with very dense packing of nucleic acids." @default.
• W4220925195 created "2022-04-03" @default.
• W4220925195 creator A5038692272 @default.
• W4220925195 creator A5059620610 @default.
• W4220925195 date "2022-03-23" @default.
• W4220925195 modified "2023-09-27" @default.
• W4220925195 title "Tuning Formation of Protein–DNA Coacervates by Sequence and Environment" @default.
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