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- W4220928000 abstract "Nyctanthes arbor-tristis L. contains various phytochemicals with tremendous potential to fight against different infections. However, the effect of these phytochemicals on Mycobacterium tuberculosis is yet unknown. Treatment of multi-drug resistance (MDR) and extensively drug-resistant (XDR) strains of the tuberculosis bacterium are still challenging. Therefore, there is an urgent need to overcome this problem. The present review focuses on the potential action of the hypolipidemic phytochemicals obtained from N. arbor-tristis on the growth and survival of M. tuberculosis in the human host. The extracts from different parts of this plant are hypolipidemic by various established mechanisms. Phytochemicals like iridoids and flavonoids from plant origin exhibit a high capacity to regulate cholesterol and fatty acid biosynthesis in vivo. The hypolipidemic properties of N. arbor-tristis-derived extracts are probably due to the presence of phytochemicals such as iridoids, flavonoids, etc. It may regulate fatty acid biosynthesis in M. tuberculosis by targeting bacterial fatty acid synthase enzyme. Additionally, these phytochemicals also inhibit cholesterol biosynthesis in the host by interrupting the function of HMG-CoA reductase. M. tuberculosis is an intracellular pathogen. It is also established fact as on date that entry of tuberculosis bacterium in the macrophage is macrophage membrane cholesterol-dependent. Host cholesterol is also otherwise necessary by multiple mechanisms for the pathogenesis of tuberculosis. Based on the above facts, we believe that N. arbor-tristis derived phytochemicals can act both on the tuberculosis bacterium and on the host for prevention and cure of tuberculosis." @default.
- W4220928000 created "2022-04-03" @default.
- W4220928000 creator A5044639967 @default.
- W4220928000 creator A5054828977 @default.
- W4220928000 date "2022-03-04" @default.
- W4220928000 modified "2023-10-16" @default.
- W4220928000 title "Nyctanthes arbor-tristis L.: Perspective of phytochemical-based inhibition of fatty acid biosynthesis in Mycobacterium tuberculosis" @default.
- W4220928000 cites W1516567585 @default.
- W4220928000 cites W1560543114 @default.
- W4220928000 cites W1632848871 @default.
- W4220928000 cites W1834474486 @default.
- W4220928000 cites W1857542255 @default.
- W4220928000 cites W1963501806 @default.
- W4220928000 cites W1963958736 @default.
- W4220928000 cites W1966542159 @default.
- W4220928000 cites W1967981179 @default.
- W4220928000 cites W1976358336 @default.
- W4220928000 cites W1976821513 @default.
- W4220928000 cites W1978072654 @default.
- W4220928000 cites W1978811871 @default.
- W4220928000 cites W1980976262 @default.
- W4220928000 cites W1981444004 @default.
- W4220928000 cites W1983849719 @default.
- W4220928000 cites W1985019749 @default.
- W4220928000 cites W1985293591 @default.
- W4220928000 cites W1988975966 @default.
- W4220928000 cites W1990751005 @default.
- W4220928000 cites W1991233072 @default.
- W4220928000 cites W1991354189 @default.
- W4220928000 cites W1991932165 @default.
- W4220928000 cites W1995292346 @default.
- W4220928000 cites W1996907187 @default.
- W4220928000 cites W2000377779 @default.
- W4220928000 cites W2001644952 @default.
- W4220928000 cites W2006539642 @default.
- W4220928000 cites W2010096264 @default.
- W4220928000 cites W2011358501 @default.
- W4220928000 cites W2012416622 @default.
- W4220928000 cites W2022093637 @default.
- W4220928000 cites W2023581789 @default.
- W4220928000 cites W2025034007 @default.
- W4220928000 cites W2025142419 @default.
- W4220928000 cites W2026631712 @default.
- W4220928000 cites W2029437834 @default.
- W4220928000 cites W2031075112 @default.
- W4220928000 cites W2033541022 @default.
- W4220928000 cites W2034507681 @default.
- W4220928000 cites W2037672318 @default.
- W4220928000 cites W2039394359 @default.
- W4220928000 cites W2041592230 @default.
- W4220928000 cites W2044462034 @default.
- W4220928000 cites W2045014762 @default.
- W4220928000 cites W2048639140 @default.
- W4220928000 cites W2049950530 @default.
- W4220928000 cites W2053619539 @default.
- W4220928000 cites W2053867514 @default.
- W4220928000 cites W2062059821 @default.
- W4220928000 cites W2065675200 @default.
- W4220928000 cites W2067065265 @default.
- W4220928000 cites W2072186466 @default.
- W4220928000 cites W2080275536 @default.
- W4220928000 cites W2082011949 @default.
- W4220928000 cites W2089103277 @default.
- W4220928000 cites W2090157491 @default.
- W4220928000 cites W2091017555 @default.
- W4220928000 cites W2094951606 @default.
- W4220928000 cites W2097144541 @default.
- W4220928000 cites W2098758975 @default.
- W4220928000 cites W2105779843 @default.
- W4220928000 cites W2117884200 @default.
- W4220928000 cites W2120544466 @default.
- W4220928000 cites W2123069059 @default.
- W4220928000 cites W2126628935 @default.
- W4220928000 cites W2132295452 @default.
- W4220928000 cites W2136564653 @default.
- W4220928000 cites W2137220276 @default.
- W4220928000 cites W2138034858 @default.
- W4220928000 cites W2139009731 @default.
- W4220928000 cites W2141867433 @default.
- W4220928000 cites W2145580800 @default.
- W4220928000 cites W2146522511 @default.
- W4220928000 cites W2147829286 @default.
- W4220928000 cites W2149828455 @default.
- W4220928000 cites W2164718888 @default.
- W4220928000 cites W2166822423 @default.
- W4220928000 cites W2167983164 @default.
- W4220928000 cites W2168371141 @default.
- W4220928000 cites W2169313892 @default.
- W4220928000 cites W2172137232 @default.
- W4220928000 cites W2341667628 @default.
- W4220928000 cites W2395066099 @default.
- W4220928000 cites W2883065666 @default.
- W4220928000 cites W2889126461 @default.
- W4220928000 cites W3021031937 @default.
- W4220928000 cites W4254419430 @default.
- W4220928000 cites W91892326 @default.
- W4220928000 doi "https://doi.org/10.55484/ijpbp.1049943" @default.
- W4220928000 hasPublicationYear "2022" @default.
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