Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220930143> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4220930143 abstract "Abstract Background : Treatment of non-small cell lung cancer (NSCLC) patients with interstitial lung disease (ILD) is limited because of the risk of its acute exacerbation (AE). Furthermore, the efficacy and safety of second-line chemotherapy for these patients is unclear. Patients and Methods : To investigate the efficacy and safety of second-line chemotherapy for NSCLC patients with ILD, we retrospectively reviewed the patients who were treated at our institute between April 2010 and December 2018. Results : Thirty-five patients received two or more regimens. Thirty-four patients were male and the median age at the initiation of second-line chemotherapy was 70 years. Almost all patients had a smoking history. Fourteen patients had adenocarcinoma and 15 had squamous cell carcinoma histology. Stages Ⅲ and Ⅳ were observed in 20 and 11 patients, respectively. With respect to the type of ILD, 12 patients had usual interstitial pneumonia (UIP). The overall response rate and disease control rate were 11.4% and 68.6%, respectively. The median progression-free survival and median overall survival were 4.1 months and 6.4 months, respectively. The AE of ILD was observed in eight patients, five of whom died. UIP and low % vital capacity were detected as significant risk factors for the AE of ILD. Conclusion : Second-line chemotherapy among patients with NSCLC complicated by ILD showed a certain effectiveness, but some patients experienced the AE of ILD, which may lead to death. The risk of the AE of ILD must be considered especially for patients with UIP and low %VC." @default.
- W4220930143 created "2022-04-03" @default.
- W4220930143 creator A5004508818 @default.
- W4220930143 creator A5016366834 @default.
- W4220930143 creator A5018111348 @default.
- W4220930143 creator A5020327537 @default.
- W4220930143 creator A5029110597 @default.
- W4220930143 creator A5038728088 @default.
- W4220930143 creator A5071216293 @default.
- W4220930143 creator A5074533118 @default.
- W4220930143 date "2022-03-18" @default.
- W4220930143 modified "2023-10-15" @default.
- W4220930143 title "The Efficacy and Safety of Second-Line Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer Complicated by Interstitial Lung Disease" @default.
- W4220930143 doi "https://doi.org/10.21203/rs.3.rs-1456228/v1" @default.
- W4220930143 hasPublicationYear "2022" @default.
- W4220930143 type Work @default.
- W4220930143 citedByCount "0" @default.
- W4220930143 crossrefType "posted-content" @default.
- W4220930143 hasAuthorship W4220930143A5004508818 @default.
- W4220930143 hasAuthorship W4220930143A5016366834 @default.
- W4220930143 hasAuthorship W4220930143A5018111348 @default.
- W4220930143 hasAuthorship W4220930143A5020327537 @default.
- W4220930143 hasAuthorship W4220930143A5029110597 @default.
- W4220930143 hasAuthorship W4220930143A5038728088 @default.
- W4220930143 hasAuthorship W4220930143A5071216293 @default.
- W4220930143 hasAuthorship W4220930143A5074533118 @default.
- W4220930143 hasBestOaLocation W42209301431 @default.
- W4220930143 hasConcept C121608353 @default.
- W4220930143 hasConcept C126322002 @default.
- W4220930143 hasConcept C143998085 @default.
- W4220930143 hasConcept C2776256026 @default.
- W4220930143 hasConcept C2776694085 @default.
- W4220930143 hasConcept C2776907518 @default.
- W4220930143 hasConcept C2777014857 @default.
- W4220930143 hasConcept C2777405647 @default.
- W4220930143 hasConcept C2777543607 @default.
- W4220930143 hasConcept C2777714996 @default.
- W4220930143 hasConcept C2781182431 @default.
- W4220930143 hasConcept C71924100 @default.
- W4220930143 hasConcept C90924648 @default.
- W4220930143 hasConceptScore W4220930143C121608353 @default.
- W4220930143 hasConceptScore W4220930143C126322002 @default.
- W4220930143 hasConceptScore W4220930143C143998085 @default.
- W4220930143 hasConceptScore W4220930143C2776256026 @default.
- W4220930143 hasConceptScore W4220930143C2776694085 @default.
- W4220930143 hasConceptScore W4220930143C2776907518 @default.
- W4220930143 hasConceptScore W4220930143C2777014857 @default.
- W4220930143 hasConceptScore W4220930143C2777405647 @default.
- W4220930143 hasConceptScore W4220930143C2777543607 @default.
- W4220930143 hasConceptScore W4220930143C2777714996 @default.
- W4220930143 hasConceptScore W4220930143C2781182431 @default.
- W4220930143 hasConceptScore W4220930143C71924100 @default.
- W4220930143 hasConceptScore W4220930143C90924648 @default.
- W4220930143 hasLocation W42209301431 @default.
- W4220930143 hasOpenAccess W4220930143 @default.
- W4220930143 hasPrimaryLocation W42209301431 @default.
- W4220930143 hasRelatedWork W2234805389 @default.
- W4220930143 hasRelatedWork W2358156577 @default.
- W4220930143 hasRelatedWork W2406311519 @default.
- W4220930143 hasRelatedWork W2552718600 @default.
- W4220930143 hasRelatedWork W2564916912 @default.
- W4220930143 hasRelatedWork W2743740828 @default.
- W4220930143 hasRelatedWork W3031381806 @default.
- W4220930143 hasRelatedWork W3212536654 @default.
- W4220930143 hasRelatedWork W4311448369 @default.
- W4220930143 hasRelatedWork W4311697951 @default.
- W4220930143 isParatext "false" @default.
- W4220930143 isRetracted "false" @default.
- W4220930143 workType "article" @default.