FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220931159> ?p ?o ?g. }

• W4220931159 abstract "ABSTRACT The insular cortex, or insula, is a large brain region involved in the detection of thirst and the control of water intake. However our understanding of the topographical, circuit and molecular mechanisms the controlling water intake within the insula remains parcellated. We found that type-1 cannabinoid receptors (CB 1 ) within the insular cortex participate to the regulation of water intake, and deconstructed circuit mechanisms of this control. Topographically, we revealed that the activity of excitatory neurons in both anterior (aIC) and posterior (pIC) insula increases in response to water intake, yet removal of CB 1 receptors only in the pIC decreases water intake. Interestingly, we found that CB 1 receptors are highly expressed in insula projections to the basolateral amygdala (BLA), while undetectable in the neighboring central part of the amygdala. Thus, we imaged the neurons of the anterior or posterior insula targeting the BLA (aIC-BLA and pIC-BLA), and found they oppositely respond to water intake, respectively decreasing and increasing their activity upon water drinking. Consistently, chemogenetic activation of pIC-BLA neurons decreased water intake. Finally, we uncovered CB 1 -dependent short term synaptic plasticity (depolarization-induced suppression of excitation, DSE) selectively in pIC-BLA, compared to aIC-BLA synapses. Altogether, our results support a model where CB 1 signaling in the pIC-BLA pathway exerts a positive control on water intake." @default.
• W4220931159 created "2022-04-03" @default.
• W4220931159 creator A5002139090 @default.
• W4220931159 creator A5005745965 @default.
• W4220931159 creator A5017659334 @default.
• W4220931159 creator A5029225082 @default.
• W4220931159 creator A5050536895 @default.
• W4220931159 creator A5053388087 @default.
• W4220931159 creator A5059361133 @default.
• W4220931159 creator A5066398025 @default.
• W4220931159 creator A5071915294 @default.
• W4220931159 creator A5086388313 @default.
• W4220931159 date "2022-03-20" @default.
• W4220931159 modified "2023-10-13" @default.
• W4220931159 title "Cannabinoids regulate an insula circuit controlling water intake" @default.
• W4220931159 cites W1603346011 @default.
• W4220931159 cites W1893851251 @default.
• W4220931159 cites W1966403223 @default.
• W4220931159 cites W1982291289 @default.
• W4220931159 cites W1997982013 @default.
• W4220931159 cites W1999359706 @default.
• W4220931159 cites W2018305067 @default.
• W4220931159 cites W2024121465 @default.
• W4220931159 cites W2058996486 @default.
• W4220931159 cites W2065977949 @default.
• W4220931159 cites W2066134510 @default.
• W4220931159 cites W2082525414 @default.
• W4220931159 cites W2098529644 @default.
• W4220931159 cites W2099878623 @default.
• W4220931159 cites W2115093212 @default.
• W4220931159 cites W2116562654 @default.
• W4220931159 cites W2121379737 @default.
• W4220931159 cites W2133702956 @default.
• W4220931159 cites W2134429437 @default.
• W4220931159 cites W2153392906 @default.
• W4220931159 cites W2162227712 @default.
• W4220931159 cites W2163438163 @default.
• W4220931159 cites W2180746000 @default.
• W4220931159 cites W2182473436 @default.
• W4220931159 cites W2212580606 @default.
• W4220931159 cites W2259648020 @default.
• W4220931159 cites W2551139658 @default.
• W4220931159 cites W2600915635 @default.
• W4220931159 cites W2604177050 @default.
• W4220931159 cites W2612118278 @default.
• W4220931159 cites W2624524674 @default.
• W4220931159 cites W2646263679 @default.
• W4220931159 cites W2750692092 @default.
• W4220931159 cites W2768029427 @default.
• W4220931159 cites W2782162792 @default.
• W4220931159 cites W2803922306 @default.
• W4220931159 cites W2909810226 @default.
• W4220931159 cites W2919930362 @default.
• W4220931159 cites W2970067111 @default.
• W4220931159 cites W3000715106 @default.
• W4220931159 cites W3003257487 @default.
• W4220931159 cites W3014185824 @default.
• W4220931159 cites W3037953639 @default.
• W4220931159 cites W3087121455 @default.
• W4220931159 cites W3092233336 @default.
• W4220931159 cites W3093167159 @default.
• W4220931159 cites W3139401529 @default.
• W4220931159 cites W3203394223 @default.
• W4220931159 cites W3209876702 @default.
• W4220931159 cites W4214524583 @default.
• W4220931159 cites W4242430352 @default.
• W4220931159 cites W51456614 @default.
• W4220931159 doi "https://doi.org/10.1101/2022.03.18.484736" @default.
• W4220931159 hasPublicationYear "2022" @default.
• W4220931159 type Work @default.
• W4220931159 citedByCount "1" @default.
• W4220931159 countsByYear W42209311592022 @default.
• W4220931159 crossrefType "posted-content" @default.
• W4220931159 hasAuthorship W4220931159A5002139090 @default.
• W4220931159 hasAuthorship W4220931159A5005745965 @default.
• W4220931159 hasAuthorship W4220931159A5017659334 @default.
• W4220931159 hasAuthorship W4220931159A5029225082 @default.
• W4220931159 hasAuthorship W4220931159A5050536895 @default.
• W4220931159 hasAuthorship W4220931159A5053388087 @default.
• W4220931159 hasAuthorship W4220931159A5059361133 @default.
• W4220931159 hasAuthorship W4220931159A5066398025 @default.
• W4220931159 hasAuthorship W4220931159A5071915294 @default.
• W4220931159 hasAuthorship W4220931159A5086388313 @default.
• W4220931159 hasBestOaLocation W42209311591 @default.
• W4220931159 hasConcept C104996578 @default.
• W4220931159 hasConcept C112592302 @default.
• W4220931159 hasConcept C134018914 @default.
• W4220931159 hasConcept C15744967 @default.
• W4220931159 hasConcept C169760540 @default.
• W4220931159 hasConcept C17077164 @default.
• W4220931159 hasConcept C185592680 @default.
• W4220931159 hasConcept C2779144063 @default.
• W4220931159 hasConcept C2780539906 @default.
• W4220931159 hasConcept C2993761234 @default.
• W4220931159 hasConcept C86803240 @default.
• W4220931159 hasConceptScore W4220931159C104996578 @default.
• W4220931159 hasConceptScore W4220931159C112592302 @default.
• W4220931159 hasConceptScore W4220931159C134018914 @default.
• W4220931159 hasConceptScore W4220931159C15744967 @default.
• W4220931159 hasConceptScore W4220931159C169760540 @default.

• next